RTP2_MOUSE
ID RTP2_MOUSE Reviewed; 223 AA.
AC Q80ZI2;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Receptor-transporting protein 2;
GN Name=Rtp2; Synonyms=Gm605;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INTERACTION WITH OLFACTORY RECEPTORS.
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Specifically promotes functional cell surface expression of
CC olfactory receptors, but not of other GPCRs.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SUBUNIT: Interacts with olfactory receptors.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15550249};
CC Single-pass type III membrane protein {ECO:0000269|PubMed:15550249}.
CC Note=Effective cell surface expression depends upon interaction with
CC olfactory receptors.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in olfactory and
CC vomeronasal organs, in mature olfactory sensory neurons.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR EMBL; AY562226; AAT70671.1; -; mRNA.
DR EMBL; BC049158; AAH49158.1; -; mRNA.
DR CCDS; CCDS28081.1; -.
DR RefSeq; NP_001008231.1; NM_001008230.3.
DR AlphaFoldDB; Q80ZI2; -.
DR STRING; 10090.ENSMUSP00000062178; -.
DR PhosphoSitePlus; Q80ZI2; -.
DR MaxQB; Q80ZI2; -.
DR PaxDb; Q80ZI2; -.
DR PRIDE; Q80ZI2; -.
DR ProteomicsDB; 260743; -.
DR Antibodypedia; 19329; 94 antibodies from 17 providers.
DR DNASU; 224055; -.
DR Ensembl; ENSMUST00000061030; ENSMUSP00000062178; ENSMUSG00000047531.
DR GeneID; 224055; -.
DR KEGG; mmu:224055; -.
DR UCSC; uc007yty.1; mouse.
DR CTD; 344892; -.
DR MGI; MGI:2685451; Rtp2.
DR VEuPathDB; HostDB:ENSMUSG00000047531; -.
DR eggNOG; ENOG502S1UZ; Eukaryota.
DR GeneTree; ENSGT00940000162172; -.
DR HOGENOM; CLU_092465_0_0_1; -.
DR InParanoid; Q80ZI2; -.
DR OMA; DSWELIM; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q80ZI2; -.
DR TreeFam; TF333246; -.
DR BioGRID-ORCS; 224055; 5 hits in 73 CRISPR screens.
DR PRO; PR:Q80ZI2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q80ZI2; protein.
DR Bgee; ENSMUSG00000047531; Expressed in respiratory tract epithelium and 6 other tissues.
DR ExpressionAtlas; Q80ZI2; baseline and differential.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0031849; F:olfactory receptor binding; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; ISO:MGI.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..223
FT /note="Receptor-transporting protein 2"
FT /id="PRO_0000181992"
FT TOPO_DOM 1..193
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 223 AA; 25900 MW; 95BFB8359D22C669 CRC64;
MSTSLTTCEW KKVFYEKMEV AKPADSWELI IDPTLKPNEL GPGWKQYLEQ HASGRFHCSW
CWHTWQSANV VILFHMHLDR AQRVGSVRMR VFKQLCYQCG TSRLDESSML EENIEGLVDN
LITSLREQCY DEDGGQYRIH VASRPDSGLH RSEFCEACQE GIVHWKPSEK LLEEDAAYTD
ASKKKGQAGF ISSFFSFRWC LFWGTLCLVI VYLQFFRGRS GFL
