RTP2_TRYBG
ID RTP2_TRYBG Reviewed; 1182 AA.
AC P15594;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Retrotransposable element SLACS 132 kDa protein;
DE AltName: Full=ORF2;
DE Includes:
DE RecName: Full=Reverse transcriptase;
DE EC=2.7.7.49;
OS Trypanosoma brucei gambiense.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=31285;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2156231; DOI=10.1093/nar/18.4.785;
RA Aksoy S., Williams S., Chang S., Richards F.F.;
RT "SLACS retrotransposon from Trypanosoma brucei gambiense is similar to
RT mammalian LINEs.";
RL Nucleic Acids Res. 18:785-792(1990).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU00405};
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DR EMBL; X17078; CAA34931.1; -; Genomic_DNA.
DR PIR; S14916; S14916.
DR AlphaFoldDB; P15594; -.
DR PRIDE; P15594; -.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase;
KW Transposable element.
FT CHAIN 1..1182
FT /note="Retrotransposable element SLACS 132 kDa protein"
FT /id="PRO_0000097521"
FT DOMAIN 560..790
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1182 AA; 132793 MW; E11D9DBC038BBA17 CRC64;
MEGPSNPGEN LGIISVNPNT CESIELTNQI LAKTYTTSWT DMEVYARGNG RICTAYPDVD
HPLQDVRGNV SSILERGERS GGFETHPPRD PVTPRERHGN IQTRGAVIAP TPFHVVAAIP
QQTRKRRWDI LDGMVRRTVS QSTVDPKTVV MCVYRREEEE TYDVLDEEEQ DDDLLGIPNP
TPRRLRISQA GPQQNSWVDT RGRRAYGSQE EQDERTSTDQ VSIFSHDETR ELSSPLECPI
VGCTASFVGP RRWEKAKSHI YGVHSLEEVR EIPRGELICK GIVRCETCAT LLPTSDRAKQ
AHRDDCRPYL PRKENIRRKR AAEREATEAS AQQGIALRLE RQGPYITPRD IEEPTNTTTE
SWWREKVATK RYLHRKEWPQ WLDICRTVLL GYSASSQGER HQRQVMLLDL VRNHLHTRTA
RREQQQQRGK DNQEEEDRQK KEEKSLRNAW KPCASSVRQG GQPSSSQPKR LNRWSTAPKW
LKQSGNCTRR RISMIFPGPP VEQPGVVSVD AEEVAKTIAR RLTRGAAPGL DGWTRELLYP
LTLDPALKME IAAVVKDIIN ADVSMEVGRR LQATSLTVLR KPNGKYRPIG AESVWAKLAS
HIAISRVMKT AEKKFSGIQF GVGGHIEEAI AKIRKDFATK GSLAMLDGRN AYNAISRRAI
LEAVYGDSTW SPLWRLVSLL LGTTGEVGFY ENGKLCHTWE STRGVRQGMV LGPLLFSIGT
LATLRRLQQT FPEAQFTAYL DDVTVAAPPE ELKNVCAATA EAMEALGIVN NADKTEVLEL
TGDTGFGTAV KRVREFLERT WPDPMSEEIR EGVEKKAMET DRLFKAIVEL PLYNRTRWRI
LAMSAMPRIT FLLRNHDMQH THRVASWFDE RTTQVMEHIL GQPMTERARN IAALPVSMGG
CGIRRMAQVA EYAHQCAGEK GLQQRKTEEA DQRQQDDLYA TLGGADRQVF TANTAAGAGR
PLTDAQVRLD DATFGVYLRE RYCRVLPEGV KCLCGEDASN HHIHTGTKVH NKPRQMRHDI
INSVFANGLR LCGFQCATEP RLNEVSKRRP DILIAGLDTY AVTDITVTYP GRVTVGNTAQ
GQRSVAAADP MKAALVAFQE KERKYSYWAI QNGLAFAPFV MLTNGAIFGK SRDWLRRVLR
GQDHRLTVTT AFDGITADVV AAVLRGNVHV YSAAQARGET LR