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RTP2_TRYBG
ID   RTP2_TRYBG              Reviewed;        1182 AA.
AC   P15594;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Retrotransposable element SLACS 132 kDa protein;
DE   AltName: Full=ORF2;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
OS   Trypanosoma brucei gambiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31285;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2156231; DOI=10.1093/nar/18.4.785;
RA   Aksoy S., Williams S., Chang S., Richards F.F.;
RT   "SLACS retrotransposon from Trypanosoma brucei gambiense is similar to
RT   mammalian LINEs.";
RL   Nucleic Acids Res. 18:785-792(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; X17078; CAA34931.1; -; Genomic_DNA.
DR   PIR; S14916; S14916.
DR   AlphaFoldDB; P15594; -.
DR   PRIDE; P15594; -.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase; RNA-directed DNA polymerase; Transferase;
KW   Transposable element.
FT   CHAIN           1..1182
FT                   /note="Retrotransposable element SLACS 132 kDa protein"
FT                   /id="PRO_0000097521"
FT   DOMAIN          560..790
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   REGION          77..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..448
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..478
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1182 AA;  132793 MW;  E11D9DBC038BBA17 CRC64;
     MEGPSNPGEN LGIISVNPNT CESIELTNQI LAKTYTTSWT DMEVYARGNG RICTAYPDVD
     HPLQDVRGNV SSILERGERS GGFETHPPRD PVTPRERHGN IQTRGAVIAP TPFHVVAAIP
     QQTRKRRWDI LDGMVRRTVS QSTVDPKTVV MCVYRREEEE TYDVLDEEEQ DDDLLGIPNP
     TPRRLRISQA GPQQNSWVDT RGRRAYGSQE EQDERTSTDQ VSIFSHDETR ELSSPLECPI
     VGCTASFVGP RRWEKAKSHI YGVHSLEEVR EIPRGELICK GIVRCETCAT LLPTSDRAKQ
     AHRDDCRPYL PRKENIRRKR AAEREATEAS AQQGIALRLE RQGPYITPRD IEEPTNTTTE
     SWWREKVATK RYLHRKEWPQ WLDICRTVLL GYSASSQGER HQRQVMLLDL VRNHLHTRTA
     RREQQQQRGK DNQEEEDRQK KEEKSLRNAW KPCASSVRQG GQPSSSQPKR LNRWSTAPKW
     LKQSGNCTRR RISMIFPGPP VEQPGVVSVD AEEVAKTIAR RLTRGAAPGL DGWTRELLYP
     LTLDPALKME IAAVVKDIIN ADVSMEVGRR LQATSLTVLR KPNGKYRPIG AESVWAKLAS
     HIAISRVMKT AEKKFSGIQF GVGGHIEEAI AKIRKDFATK GSLAMLDGRN AYNAISRRAI
     LEAVYGDSTW SPLWRLVSLL LGTTGEVGFY ENGKLCHTWE STRGVRQGMV LGPLLFSIGT
     LATLRRLQQT FPEAQFTAYL DDVTVAAPPE ELKNVCAATA EAMEALGIVN NADKTEVLEL
     TGDTGFGTAV KRVREFLERT WPDPMSEEIR EGVEKKAMET DRLFKAIVEL PLYNRTRWRI
     LAMSAMPRIT FLLRNHDMQH THRVASWFDE RTTQVMEHIL GQPMTERARN IAALPVSMGG
     CGIRRMAQVA EYAHQCAGEK GLQQRKTEEA DQRQQDDLYA TLGGADRQVF TANTAAGAGR
     PLTDAQVRLD DATFGVYLRE RYCRVLPEGV KCLCGEDASN HHIHTGTKVH NKPRQMRHDI
     INSVFANGLR LCGFQCATEP RLNEVSKRRP DILIAGLDTY AVTDITVTYP GRVTVGNTAQ
     GQRSVAAADP MKAALVAFQE KERKYSYWAI QNGLAFAPFV MLTNGAIFGK SRDWLRRVLR
     GQDHRLTVTT AFDGITADVV AAVLRGNVHV YSAAQARGET LR
 
 
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