RTP3_HUMAN
ID RTP3_HUMAN Reviewed; 232 AA.
AC Q9BQQ7; A2RRP6;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Receptor-transporting protein 3;
DE AltName: Full=3CxxC-type zinc finger protein 3;
DE AltName: Full=Transmembrane protein 7;
GN Name=RTP3; Synonyms=TMEM7, Z3CXXC3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11896456; DOI=10.1038/sj.ejhg.5200758;
RA Kiss H., Yang Y., Kiss C., Andersson K., Klein G., Imreh S., Dumanski J.P.;
RT "The transcriptional map of the common eliminated region 1 (C3CER1) in
RT 3p21.3.";
RL Eur. J. Hum. Genet. 10:52-61(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH TAS2R16, AND TISSUE SPECIFICITY.
RX PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT "Members of RTP and REEP gene families influence functional bitter taste
RT receptor expression.";
RL J. Biol. Chem. 281:20650-20659(2006).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=17693185; DOI=10.1016/j.cancergencyto.2007.04.007;
RA Zhou X., Popescu N.C., Klein G., Imreh S.;
RT "The interferon-alpha responsive gene TMEM7 suppresses cell proliferation
RT and is downregulated in human hepatocellular carcinoma.";
RL Cancer Genet. Cytogenet. 177:6-15(2007).
CC -!- FUNCTION: Promotes functional cell surface expression of the bitter
CC taste receptors TAS2R16 and TAS2R43. {ECO:0000269|PubMed:16720576}.
CC -!- SUBUNIT: Interacts with TAS2R16. {ECO:0000269|PubMed:16720576}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in adult liver
CC (PubMed:11896456, PubMed:17693185). Expressed in testis
CC (PubMed:16720576, PubMed:17693185). Also expressed in kidney, lung and
CC fetal liver (PubMed:17693185). Low levels in heart, thyroid, adrenal
CC gland, pancreas, ovary, prostate, skin, plasma leukocytes, bone marrow
CC and fetal brain (PubMed:17693185). Not detected in brain, spleen,
CC colon, small intestine, skeletal muscle, stomach, placenta, salivary
CC gland and uterus (PubMed:17693185). {ECO:0000269|PubMed:11896456,
CC ECO:0000269|PubMed:16720576, ECO:0000269|PubMed:17693185}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ312776; CAC37401.1; -; mRNA.
DR EMBL; AY562237; AAT70682.1; -; mRNA.
DR EMBL; CH471055; EAW64768.1; -; Genomic_DNA.
DR EMBL; BC131756; AAI31757.1; -; mRNA.
DR CCDS; CCDS2740.1; -.
DR RefSeq; NP_113628.1; NM_031440.1.
DR AlphaFoldDB; Q9BQQ7; -.
DR BioGRID; 123693; 11.
DR STRING; 9606.ENSP00000296142; -.
DR iPTMnet; Q9BQQ7; -.
DR PhosphoSitePlus; Q9BQQ7; -.
DR BioMuta; RTP3; -.
DR DMDM; 23822259; -.
DR MassIVE; Q9BQQ7; -.
DR PaxDb; Q9BQQ7; -.
DR PeptideAtlas; Q9BQQ7; -.
DR PRIDE; Q9BQQ7; -.
DR ProteomicsDB; 78709; -.
DR Antibodypedia; 2565; 57 antibodies from 11 providers.
DR DNASU; 83597; -.
DR Ensembl; ENST00000296142.4; ENSP00000296142.3; ENSG00000163825.5.
DR Ensembl; ENST00000684260.1; ENSP00000507138.1; ENSG00000163825.5.
DR GeneID; 83597; -.
DR KEGG; hsa:83597; -.
DR MANE-Select; ENST00000296142.4; ENSP00000296142.3; NM_031440.2; NP_113628.1.
DR UCSC; uc003cps.2; human.
DR CTD; 83597; -.
DR DisGeNET; 83597; -.
DR GeneCards; RTP3; -.
DR HGNC; HGNC:15572; RTP3.
DR HPA; ENSG00000163825; Tissue enriched (liver).
DR MIM; 607181; gene.
DR neXtProt; NX_Q9BQQ7; -.
DR OpenTargets; ENSG00000163825; -.
DR PharmGKB; PA37981; -.
DR VEuPathDB; HostDB:ENSG00000163825; -.
DR eggNOG; ENOG502S6AA; Eukaryota.
DR GeneTree; ENSGT00940000162454; -.
DR HOGENOM; CLU_045693_0_0_1; -.
DR InParanoid; Q9BQQ7; -.
DR OMA; NHICRNL; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q9BQQ7; -.
DR TreeFam; TF333246; -.
DR PathwayCommons; Q9BQQ7; -.
DR BioGRID-ORCS; 83597; 9 hits in 1064 CRISPR screens.
DR GenomeRNAi; 83597; -.
DR Pharos; Q9BQQ7; Tbio.
DR PRO; PR:Q9BQQ7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BQQ7; protein.
DR Bgee; ENSG00000163825; Expressed in right lobe of liver and 36 other tissues.
DR Genevisible; Q9BQQ7; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031849; F:olfactory receptor binding; IBA:GO_Central.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:HGNC-UCL.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IDA:HGNC-UCL.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR026691; RTP3.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 2.
DR PANTHER; PTHR14402:SF9; PTHR14402:SF9; 2.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..232
FT /note="Receptor-transporting protein 3"
FT /id="PRO_0000181993"
FT TOPO_DOM 1..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 232 AA; 27031 MW; 352377BDF4110237 CRC64;
MAGDTEVWKQ MFQELMREVK PWHRWTLRPD KGLLPNVLKP GWMQYQQWTF ARFQCSSCSR
NWASAQVLVL FHMNWSEEKS RGQVKMRVFT QRCKKCPQPL FEDPEFTQEN ISRILKNLVF
RILKKCYRGR FQLIEEVPMI KDISLEGPHN SDNCEACLQG FCAGPIQVTS LPPSQTPRVH
SIYKVEEVVK PWASGENVYS YACQNHICRN LSIFCCCVIL IVIVVIVVKT AI
