RTP3_MOUSE
ID RTP3_MOUSE Reviewed; 474 AA.
AC Q5QGU6; E9QP29; Q2KHT1; Q8VDC2;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Receptor-transporting protein 3;
DE AltName: Full=Transmembrane protein 7;
GN Name=Rtp3; Synonyms=Tmem7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=12461651; DOI=10.1007/s00335-002-3037-y;
RA Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P.,
RA Imreh S.;
RT "Comparative human/murine sequence analysis of the common eliminated region
RT 1 from human 3p21.3.";
RL Mamm. Genome 13:646-655(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Promotes functional cell surface expression of the bitter
CC taste receptors TAS2R16 and TAS2R43. {ECO:0000250|UniProtKB:Q9BQQ7}.
CC -!- SUBUNIT: Interacts with TAS2R16. {ECO:0000250|UniProtKB:Q9BQQ7}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the liver. Not detected
CC in the olfactory epithelium. {ECO:0000269|PubMed:12461651,
CC ECO:0000269|PubMed:15550249}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ428064; CAD20986.1; -; mRNA.
DR EMBL; AY562227; AAT70672.1; -; mRNA.
DR EMBL; AC118727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112903; AAI12904.1; -; mRNA.
DR CCDS; CCDS81087.1; -.
DR RefSeq; NP_694740.2; NM_153100.2.
DR AlphaFoldDB; Q5QGU6; -.
DR STRING; 10090.ENSMUSP00000081985; -.
DR iPTMnet; Q5QGU6; -.
DR PhosphoSitePlus; Q5QGU6; -.
DR SwissPalm; Q5QGU6; -.
DR MaxQB; Q5QGU6; -.
DR PaxDb; Q5QGU6; -.
DR PRIDE; Q5QGU6; -.
DR ProteomicsDB; 260744; -.
DR Antibodypedia; 2565; 57 antibodies from 11 providers.
DR Ensembl; ENSMUST00000084922; ENSMUSP00000081985; ENSMUSG00000066319.
DR Ensembl; ENSMUST00000199891; ENSMUSP00000143305; ENSMUSG00000066319.
DR GeneID; 235636; -.
DR KEGG; mmu:235636; -.
DR UCSC; uc012hbo.1; mouse.
DR CTD; 83597; -.
DR MGI; MGI:2446841; Rtp3.
DR VEuPathDB; HostDB:ENSMUSG00000066319; -.
DR eggNOG; ENOG502S6AA; Eukaryota.
DR GeneTree; ENSGT00940000162454; -.
DR InParanoid; Q5QGU6; -.
DR OMA; PANTACQ; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q5QGU6; -.
DR TreeFam; TF333246; -.
DR BioGRID-ORCS; 235636; 0 hits in 65 CRISPR screens.
DR PRO; PR:Q5QGU6; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q5QGU6; protein.
DR Bgee; ENSMUSG00000066319; Expressed in left lobe of liver and 41 other tissues.
DR ExpressionAtlas; Q5QGU6; baseline and differential.
DR Genevisible; Q5QGU6; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031849; F:olfactory receptor binding; IBA:GO_Central.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; ISO:MGI.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR026691; RTP3.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR PANTHER; PTHR14402:SF9; PTHR14402:SF9; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..474
FT /note="Receptor-transporting protein 3"
FT /id="PRO_0000181994"
FT TOPO_DOM 1..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 175..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1
FT /note="Missing (in Ref. 1; CAD20986)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="V -> A (in Ref. 1; CAD20986, 2; AAT70672 and 4;
FT AAI12904)"
FT /evidence="ECO:0000305"
FT CONFLICT 206
FT /note="R -> Q (in Ref. 1; CAD20986, 2; AAT70672 and 4;
FT AAI12904)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="V -> A (in Ref. 1; CAD20986, 2; AAT70672 and 4;
FT AAI12904)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="P -> S (in Ref. 1; CAD20986, 2; AAT70672 and 4;
FT AAI12904)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 52220 MW; CFAC15CB3E6FF069 CRC64;
MMEEDIGDTE QWRHVFQELM QEVKPWHKWT LIPDKNLLPN VLKPGWTQYQ QKTFARFHCP
SCSRSWASGR VLIVFHMRWC EKKAKGWVKM RVFAQRCNQC PEPPFATPEV TWDNISRILN
NLLFQILKKC YKEGFKQMGE IPLLGNTSLE GPHDSSNCEA CLLGFCAQND LGQASKPPAP
PLSPTSSKSA REPKVTVTCS NISSSRPSSK VQMPQASKVN PQASNPTKND PKVSCTSKPP
APPLSPTSLK SAREPKVTVT CSNISSSRPS SKVQMPQASK VNPQTSNPTK NDPKISCTSK
PSTTPRLTIQ QLSVVSPPAP APTCVIQMPS PTPIDGSRAA DVAKENTRSK TPKALLSSPL
YVPPTSSYVP PTSSYVPPTS SYVPPTSSYV PPTSSSVIVP ISSSWRLPEN TICQVERNSH
IHPQSQSSCC GACCESWCEI FRYSCCEAAC NCMSQSPLCC LAFLILFLLL WYLL
