RTP4_HUMAN
ID RTP4_HUMAN Reviewed; 246 AA.
AC Q96DX8; Q9H4F3;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Receptor-transporting protein 4;
DE AltName: Full=28 kDa interferon-responsive protein;
DE AltName: Full=3CxxC-type zinc finger protein 4;
GN Name=RTP4; Synonyms=IFRG28, Z3CXXC4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Meritet J.F., Dron M., Tovey M.G.;
RT "Characterization of the human IFRG28, a new interferon responsive gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, INTERACTION WITH TAS2R16, AND TISSUE SPECIFICITY.
RX PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT "Members of RTP and REEP gene families influence functional bitter taste
RT receptor expression.";
RL J. Biol. Chem. 281:20650-20659(2006).
CC -!- FUNCTION: Probable chaperone protein which facilitates trafficking and
CC functional cell surface expression of some G-protein coupled receptors
CC (GPCRs). Promotes functional expression of the bitter taste receptor
CC TAS2R16 (PubMed:16720576). Also promotes functional expression of the
CC opioid receptor heterodimer OPRD1-OPRM1 (By similarity).
CC {ECO:0000250|UniProtKB:Q9ER80, ECO:0000269|PubMed:16720576}.
CC -!- SUBUNIT: Interacts with TASR16 (PubMed:16720576). Interacts with OPRD1
CC and OPRM1; the interaction promotes cell surface localization of the
CC OPDR1-OPRM1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q9ER80,
CC ECO:0000269|PubMed:16720576}.
CC -!- INTERACTION:
CC Q96DX8; Q96Q80: DERL3; NbExp=3; IntAct=EBI-12275482, EBI-12831318;
CC Q96DX8; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-12275482, EBI-356015;
CC Q96DX8; Q8IXM6: NRM; NbExp=3; IntAct=EBI-12275482, EBI-10262547;
CC Q96DX8; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-12275482, EBI-7545592;
CC Q96DX8; Q9NYW0: TAS2R10; NbExp=3; IntAct=EBI-12275482, EBI-12963900;
CC Q96DX8; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-12275482, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in circumvallate papillae and testis.
CC {ECO:0000269|PubMed:16720576}.
CC -!- INDUCTION: By interferons.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR EMBL; AY562238; AAT70683.1; -; mRNA.
DR EMBL; AJ251832; CAC14309.1; -; mRNA.
DR EMBL; AC068299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC013161; AAH13161.1; -; mRNA.
DR CCDS; CCDS33910.1; -.
DR RefSeq; NP_071430.2; NM_022147.2.
DR AlphaFoldDB; Q96DX8; -.
DR BioGRID; 122065; 9.
DR IntAct; Q96DX8; 7.
DR MINT; Q96DX8; -.
DR STRING; 9606.ENSP00000259030; -.
DR iPTMnet; Q96DX8; -.
DR PhosphoSitePlus; Q96DX8; -.
DR BioMuta; RTP4; -.
DR DMDM; 313104193; -.
DR jPOST; Q96DX8; -.
DR MassIVE; Q96DX8; -.
DR PaxDb; Q96DX8; -.
DR PeptideAtlas; Q96DX8; -.
DR PRIDE; Q96DX8; -.
DR ProteomicsDB; 76338; -.
DR Antibodypedia; 46841; 111 antibodies from 17 providers.
DR DNASU; 64108; -.
DR Ensembl; ENST00000259030.3; ENSP00000259030.2; ENSG00000136514.3.
DR GeneID; 64108; -.
DR KEGG; hsa:64108; -.
DR MANE-Select; ENST00000259030.3; ENSP00000259030.2; NM_022147.3; NP_071430.2.
DR UCSC; uc003frm.4; human.
DR CTD; 64108; -.
DR DisGeNET; 64108; -.
DR GeneCards; RTP4; -.
DR HGNC; HGNC:23992; RTP4.
DR HPA; ENSG00000136514; Low tissue specificity.
DR MIM; 609350; gene.
DR neXtProt; NX_Q96DX8; -.
DR OpenTargets; ENSG00000136514; -.
DR PharmGKB; PA143485606; -.
DR VEuPathDB; HostDB:ENSG00000136514; -.
DR eggNOG; ENOG502S085; Eukaryota.
DR GeneTree; ENSGT00940000162610; -.
DR HOGENOM; CLU_045693_0_1_1; -.
DR InParanoid; Q96DX8; -.
DR OMA; IQEAKPW; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q96DX8; -.
DR TreeFam; TF333246; -.
DR PathwayCommons; Q96DX8; -.
DR SignaLink; Q96DX8; -.
DR BioGRID-ORCS; 64108; 6 hits in 1074 CRISPR screens.
DR ChiTaRS; RTP4; human.
DR GenomeRNAi; 64108; -.
DR Pharos; Q96DX8; Tbio.
DR PRO; PR:Q96DX8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96DX8; protein.
DR Bgee; ENSG00000136514; Expressed in epithelium of nasopharynx and 125 other tissues.
DR Genevisible; Q96DX8; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031849; F:olfactory receptor binding; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:HGNC-UCL.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IDA:HGNC-UCL.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR026690; RTP4.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR PANTHER; PTHR14402:SF8; PTHR14402:SF8; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..246
FT /note="Receptor-transporting protein 4"
FT /id="PRO_0000181995"
FT TOPO_DOM 1..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 79
FT /note="T -> I (in dbSNP:rs1047584)"
FT /id="VAR_057732"
FT VARIANT 168
FT /note="S -> N (in dbSNP:rs35224605)"
FT /id="VAR_057733"
FT CONFLICT 66..67
FT /note="QV -> KL (in Ref. 1; AAT70683 and 2; CAC14309)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="T -> M (in Ref. 1; AAT70683, 2; CAC14309 and 4;
FT AAH13161)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="C -> Y (in Ref. 1; AAT70683, 2; CAC14309 and 4;
FT AAH13161)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="A -> D (in Ref. 1; AAT70683, 2; CAC14309 and 4;
FT AAH13161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 246 AA; 27863 MW; 74D61E554F1882CB CRC64;
MVVDFWTWEQ TFQELIQEAK PRATWTLKLD GNLQLDCLAQ GWKQYQQRAF GWFRCSSCQR
SWASAQVQIL CHTYWEHWTS QGQVRMRLFG QRCQKCSWSQ YEMPEFSSDS TMRILSNLVQ
HILKKYYGNG TRKSPEMPVI LEVSLEGSHD TANCEACTLG ICGQGLKSCM TKPSKSLLPH
LKTGNSSPGI GAVYLANQAK NQSAEAKEAK GSGYEKLGPS RDPDPLNICV FILLLVFIVV
KCFTSE
