RTP5_HUMAN
ID RTP5_HUMAN Reviewed; 572 AA.
AC Q14D33; Q8N2A5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Receptor-transporting protein 5;
DE AltName: Full=3CxxC-type zinc finger protein 5;
DE AltName: Full=CXXC-type zinc finger protein 11;
GN Name=RTP5; Synonyms=C2orf85, CXXC11, Z3CXXC5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-101.
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-101.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-101.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANT ASP-412.
RX PubMed=23033978; DOI=10.1056/nejmoa1206524;
RA de Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., Yntema H.G.,
RA Kroes T., Vulto-van Silfhout A.T., Koolen D.A., de Vries P., Gilissen C.,
RA del Rosario M., Hoischen A., Scheffer H., de Vries B.B., Brunner H.G.,
RA Veltman J.A., Vissers L.E.;
RT "Diagnostic exome sequencing in persons with severe intellectual
RT disability.";
RL N. Engl. J. Med. 367:1921-1929(2012).
CC -!- INTERACTION:
CC Q14D33; P35609: ACTN2; NbExp=7; IntAct=EBI-10217913, EBI-77797;
CC Q14D33; Q08043: ACTN3; NbExp=3; IntAct=EBI-10217913, EBI-2880652;
CC Q14D33; Q9ULX6: AKAP8L; NbExp=3; IntAct=EBI-10217913, EBI-357530;
CC Q14D33; P02654: APOC1; NbExp=3; IntAct=EBI-10217913, EBI-1220105;
CC Q14D33; Q86U10: ASPG; NbExp=3; IntAct=EBI-10217913, EBI-19946665;
CC Q14D33; Q7L4P6: BEND5; NbExp=3; IntAct=EBI-10217913, EBI-724373;
CC Q14D33; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-10217913, EBI-953896;
CC Q14D33; Q13137: CALCOCO2; NbExp=6; IntAct=EBI-10217913, EBI-739580;
CC Q14D33; Q9H257: CARD9; NbExp=3; IntAct=EBI-10217913, EBI-751319;
CC Q14D33; Q8NA61: CBY2; NbExp=3; IntAct=EBI-10217913, EBI-741724;
CC Q14D33; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-10217913, EBI-7062247;
CC Q14D33; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-10217913, EBI-3866319;
CC Q14D33; Q8NF50-2: DOCK8; NbExp=3; IntAct=EBI-10217913, EBI-10174653;
CC Q14D33; O00303: EIF3F; NbExp=3; IntAct=EBI-10217913, EBI-711990;
CC Q14D33; Q92915-2: FGF14; NbExp=3; IntAct=EBI-10217913, EBI-12836320;
CC Q14D33; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10217913, EBI-618309;
CC Q14D33; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10217913, EBI-5916454;
CC Q14D33; P61978: HNRNPK; NbExp=3; IntAct=EBI-10217913, EBI-304185;
CC Q14D33; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-10217913, EBI-7060731;
CC Q14D33; O75031: HSF2BP; NbExp=3; IntAct=EBI-10217913, EBI-7116203;
CC Q14D33; Q92845: KIFAP3; NbExp=3; IntAct=EBI-10217913, EBI-954040;
CC Q14D33; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10217913, EBI-3044087;
CC Q14D33; Q15323: KRT31; NbExp=3; IntAct=EBI-10217913, EBI-948001;
CC Q14D33; Q14525: KRT33B; NbExp=3; IntAct=EBI-10217913, EBI-1049638;
CC Q14D33; O76011: KRT34; NbExp=3; IntAct=EBI-10217913, EBI-1047093;
CC Q14D33; Q6A162: KRT40; NbExp=3; IntAct=EBI-10217913, EBI-10171697;
CC Q14D33; O43790: KRT86; NbExp=3; IntAct=EBI-10217913, EBI-9996498;
CC Q14D33; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-10217913, EBI-1048945;
CC Q14D33; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10217913, EBI-11962084;
CC Q14D33; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-10217913, EBI-741037;
CC Q14D33; Q99750: MDFI; NbExp=6; IntAct=EBI-10217913, EBI-724076;
CC Q14D33; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-10217913, EBI-2548751;
CC Q14D33; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-10217913, EBI-1104552;
CC Q14D33; Q13064: MKRN3; NbExp=5; IntAct=EBI-10217913, EBI-2340269;
CC Q14D33; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10217913, EBI-742948;
CC Q14D33; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10217913, EBI-11522433;
CC Q14D33; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-10217913, EBI-10271199;
CC Q14D33; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-10217913, EBI-1105124;
CC Q14D33; Q8ND90: PNMA1; NbExp=6; IntAct=EBI-10217913, EBI-302345;
CC Q14D33; Q9UL42: PNMA2; NbExp=3; IntAct=EBI-10217913, EBI-302355;
CC Q14D33; P25788: PSMA3; NbExp=3; IntAct=EBI-10217913, EBI-348380;
CC Q14D33; P60900: PSMA6; NbExp=3; IntAct=EBI-10217913, EBI-357793;
CC Q14D33; O43586: PSTPIP1; NbExp=6; IntAct=EBI-10217913, EBI-1050964;
CC Q14D33; Q93062: RBPMS; NbExp=3; IntAct=EBI-10217913, EBI-740322;
CC Q14D33; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-10217913, EBI-726876;
CC Q14D33; Q9HAT0: ROPN1; NbExp=6; IntAct=EBI-10217913, EBI-1378139;
CC Q14D33; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-10217913, EBI-748621;
CC Q14D33; P23497: SP100; NbExp=3; IntAct=EBI-10217913, EBI-751145;
CC Q14D33; P23497-2: SP100; NbExp=3; IntAct=EBI-10217913, EBI-6589365;
CC Q14D33; Q96EA4: SPDL1; NbExp=3; IntAct=EBI-10217913, EBI-715381;
CC Q14D33; Q13077: TRAF1; NbExp=3; IntAct=EBI-10217913, EBI-359224;
CC Q14D33; P36406: TRIM23; NbExp=3; IntAct=EBI-10217913, EBI-740098;
CC Q14D33; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-10217913, EBI-744794;
CC Q14D33; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10217913, EBI-739895;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK090909; BAC03544.1; -; mRNA.
DR EMBL; AC131097; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471063; EAW71299.1; -; Genomic_DNA.
DR EMBL; BC113517; AAI13518.1; -; mRNA.
DR EMBL; BC113519; AAI13520.1; -; mRNA.
DR CCDS; CCDS42843.1; -.
DR RefSeq; NP_776182.2; NM_173821.2.
DR AlphaFoldDB; Q14D33; -.
DR BioGRID; 130013; 52.
DR IntAct; Q14D33; 54.
DR MINT; Q14D33; -.
DR STRING; 9606.ENSP00000345374; -.
DR iPTMnet; Q14D33; -.
DR PhosphoSitePlus; Q14D33; -.
DR BioMuta; RTP5; -.
DR DMDM; 281371551; -.
DR PaxDb; Q14D33; -.
DR PeptideAtlas; Q14D33; -.
DR PRIDE; Q14D33; -.
DR Antibodypedia; 64441; 20 antibodies from 8 providers.
DR DNASU; 285093; -.
DR Ensembl; ENST00000343216.3; ENSP00000345374.3; ENSG00000188011.5.
DR Ensembl; ENST00000617264.2; ENSP00000482049.1; ENSG00000277949.2.
DR GeneID; 285093; -.
DR KEGG; hsa:285093; -.
DR MANE-Select; ENST00000343216.3; ENSP00000345374.3; NM_173821.3; NP_776182.2.
DR UCSC; uc010fzu.2; human.
DR CTD; 285093; -.
DR GeneCards; RTP5; -.
DR HGNC; HGNC:26585; RTP5.
DR HPA; ENSG00000188011; Tissue enriched (brain).
DR neXtProt; NX_Q14D33; -.
DR OpenTargets; ENSG00000188011; -.
DR PharmGKB; PA164717177; -.
DR VEuPathDB; HostDB:ENSG00000188011; -.
DR eggNOG; ENOG502QY6R; Eukaryota.
DR GeneTree; ENSGT00940000163732; -.
DR HOGENOM; CLU_043280_0_0_1; -.
DR InParanoid; Q14D33; -.
DR OMA; WVSMTVC; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q14D33; -.
DR TreeFam; TF333246; -.
DR PathwayCommons; Q14D33; -.
DR SignaLink; Q14D33; -.
DR BioGRID-ORCS; 285093; 8 hits in 1021 CRISPR screens.
DR GenomeRNAi; 285093; -.
DR Pharos; Q14D33; Tdark.
DR PRO; PR:Q14D33; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q14D33; protein.
DR Bgee; ENSG00000188011; Expressed in hypothalamus and 74 other tissues.
DR ExpressionAtlas; Q14D33; baseline and differential.
DR Genevisible; Q14D33; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031849; F:olfactory receptor binding; IBA:GO_Central.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR026689; CXXC11.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 3.
DR PANTHER; PTHR14402:SF2; PTHR14402:SF2; 3.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..572
FT /note="Receptor-transporting protein 5"
FT /id="PRO_0000348428"
FT TRANSMEM 544..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 101
FT /note="G -> E (in dbSNP:rs7420371)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_060791"
FT VARIANT 412
FT /note="G -> D"
FT /evidence="ECO:0000269|PubMed:23033978"
FT /id="VAR_069402"
FT CONFLICT 241
FT /note="I -> T (in Ref. 1; BAC03544)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 572 AA; 60488 MW; 00A839AA4AEC48BC CRC64;
MDRAGADMWA STFTLAMAER KPQDVWVLLP EHSLVPGCLD GGGVQYLLVG LSRLQCGHCP
GTWDSAHVHV LFHLWWDRAS HRGLVKMRIW GQRCRLCPAP GDCQVRPPGE QPFLSRLVLH
ILQDCYGDGP GPARHPREAY EGCCEACELG VCFLQKAPDP AWSANATKGN FPATAWGGTG
TVSRGKPLST PGDDLGKGGV VIAIPFSLVG TSNDQVPIAE GPAPPAGASL PVTGSCEALV
IGQGSIFLSG DSVAMPGGKG FPVAIGDPLF HGPGLLGSSI QTFELKGFLF KGRGSLCSPV
GVAQGWGPIS LNNGLVPVGK HTPTVFYCVG LSASGEGSLT FPSSLTSIFT NTLSEPTDGP
VATKEASITF PFIFTDVKDA VAEVAEGNGK EGGGQGLVPV GHDALPETNA GGLPSQVKGS
LALPFPADVQ GKDAFTDITE GKEKEGGLVT AGHDAPLEAN AEGPITVSEG CITIPFAVFD
VIKRKGGGHV AYGPQGNGCF SQGYYQKRQL RSRFHKARCG CRREEDERPG RACRRPHAEP
YEDFWIWVSM TVCVFWLMCM CRLNPGIYPQ QV
