ID   BCRC_BACLI              Reviewed;         203 AA.
AC   P42334;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Bacitracin transport permease protein BcrC;
GN   Name=bcrC;
OS   Bacillus licheniformis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9945A / NCIMB 11709;
RX   PubMed=7476193; DOI=10.1111/j.1365-2958.1995.tb02322.x;
RA   Podlesek Z., Comino A., Herzog-Velikonja B., Zgur-Bertok D., Komel R.,
RA   Grabnar M.;
RT   "Bacillus licheniformis bacitracin-resistance ABC transporter: relationship
RT   to mammalian multidrug resistance.";
RL   Mol. Microbiol. 16:969-976(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10716 / DSM 603 / NBRC 12199 / NCIMB 8874 / Tracy I;
RX   PubMed=9427658; DOI=10.1016/s1074-5521(97)90301-x;
RA   Konz D., Klens A., Schoergendorfer K., Marahiel M.A.;
RT   "The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716:
RT   molecular characterization of three multi-modular peptide synthetases.";
RL   Chem. Biol. 4:927-937(1997).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       bacitracin that confer resistance to this antibiotic; probably
CC       responsible for the translocation of the substrate across the membrane.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BcrC/YbjG family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L20573; AAA99503.1; -; Unassigned_DNA.
DR   EMBL; AF007865; AAD21215.1; -; Genomic_DNA.
DR   PIR; T31684; T31684.
DR   AlphaFoldDB; P42334; -.
DR   SMR; P42334; -.
DR   DrugBank; DB00626; Bacitracin.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050380; F:undecaprenyl-diphosphatase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03385; PAP2_BcrC_like; 1.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR033879; UPP_Pase.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..203
FT                   /note="Bacitracin transport permease protein BcrC"
FT                   /id="PRO_0000064895"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   203 AA;  23274 MW;  C096E4E6D48EE433 CRC64;
     MSFSELNIDA FRFINDLGKE YSMLNPVVYF LAEYMMYFLA LGLVVYWLTR TTKNRLMVIY
     AVIAFVVAEI LGKIMGSLHS NYQPFATLPN VNKLIEHEID NSFPSDHTIL FFSIGFLIFL
     FHKKTGWLWL VLAFAVGISR IWSGVHYPLD VAAGALLGVL SALFVFWTAP KLSFIHQMLS
     LYEKVEQRIV PSKNKSNDKS KNF