ABCG1_DICDI
ID ABCG1_DICDI Reviewed; 793 AA.
AC Q55DW4; Q8T691;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=ABC transporter G family member 1;
DE AltName: Full=ABC transporter ABCG.1;
GN Name=abcG1; ORFNames=DDB_G0269214;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL91485.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF482380; AAL91485.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000005; EAL71957.1; -; Genomic_DNA.
DR RefSeq; XP_646017.1; XM_640925.1.
DR AlphaFoldDB; Q55DW4; -.
DR SMR; Q55DW4; -.
DR STRING; 44689.DDB0191516; -.
DR TCDB; 3.A.1.204.13; the atp-binding cassette (abc) superfamily.
DR PaxDb; Q55DW4; -.
DR EnsemblProtists; EAL71957; EAL71957; DDB_G0269214.
DR GeneID; 8616965; -.
DR KEGG; ddi:DDB_G0269214; -.
DR dictyBase; DDB_G0269214; abcG1.
DR eggNOG; KOG0061; Eukaryota.
DR HOGENOM; CLU_000604_57_8_1; -.
DR InParanoid; Q55DW4; -.
DR OMA; AILMHHS; -.
DR PhylomeDB; Q55DW4; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR PRO; PR:Q55DW4; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC_2_trans.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..793
FT /note="ABC transporter G family member 1"
FT /id="PRO_0000391390"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 563..583
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 610..630
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 674..694
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 701..721
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 764..784
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 123..364
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 527..785
FT /note="ABC transmembrane type-2"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..102
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..397
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 793 AA; 89047 MW; 90B41C1910FEA3D5 CRC64;
MDSNNNNNNE NEAFSGASES SEFRKIVEEN ENEREFEQSN PSPPEYSNYE NKDDGINLET
INPNISLDNN NNNNQNNQNN QNNNNNNNNQ NNNIINNLNK KNKKRSTFKN RIDFSFKDIN
HYVQITEKGK KKKISKQILT NINGHIESGT IFAIMGPSGA GKTTLLDILA HRLNINGSGT
MYLNGNKSDF NIFKKLCGYV TQSDSLMPSL TVRETLNFYA QLKMPRDVPL KEKLQRVQDI
IDEMGLNRCA DTLVGTADNK IRGISGGERR RVTISIELLT GPSVILLDEP TSGLDASTSF
YVMSALKKLA KSGRTIICTI HQPRSNIYDM FDNLLLLGDG NTIYYGKANK ALEYFNANGY
HCSEKTNPAD FFLDLINTQV EDQADSDDDD YNDEEEEIGG GGGGSGGGAG GIEDIGISIS
PTMNGSAVDN IKNNELKQQQ QQQQQQQQST DGRARRRIKK LTKEEMVILK KEYPNSEQGL
RVNETLDNIS KENRTDFKYE KTRGPNFLTQ FSLLLGREVT NAKRHPMAFK VNLIQAIFQG
LLCGIVYYQL GLGQSSVQSR TGVVAFIIMG VSFPAVMSTI HVFPDVITIF LKDRASGVYD
TLPFFLAKSF MDACIAVLLP MVTATIVYWM TNQRVDPFYS AAPFFRFVLM LVLASQTCLS
LGVLISSSVP NVQVGTAVAP LIVILFFLFS GFFINLNDVP GWLVWFPYIS FFRYMIEAAV
INAFKDVHFT CTDSQKIGGV CPVQYGNNVI ENMGYDIDHF WRNVWILVLY IIGFRVLTFL
VLKLKSRNKF KQE
