ID   RTRAF_DANRE             Reviewed;         242 AA.
AC   Q7ZUH1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=RNA transcription, translation and transport factor protein {ECO:0000250|UniProtKB:Q9Y224};
GN   Name=rtraf {ECO:0000250|UniProtKB:Q9Y224}; ORFNames=zgc:56576;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in modulation of mRNA
CC       transcription by Polymerase II. Component of the tRNA-splicing ligase
CC       complex. {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBUNIT: Homodimer. Component of a tRNA-splicing ligase complex.
CC       {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y224}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       perinuclear region {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q9Y224}. Note=Shuttles between the cytosol and
CC       the nucleus. {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SIMILARITY: Belongs to the RTRAF family. {ECO:0000305}.
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DR   EMBL; BC049049; AAH49049.1; -; mRNA.
DR   AlphaFoldDB; Q7ZUH1; -.
DR   SMR; Q7ZUH1; -.
DR   STRING; 7955.ENSDARP00000003814; -.
DR   PaxDb; Q7ZUH1; -.
DR   PRIDE; Q7ZUH1; -.
DR   DNASU; 393240; -.
DR   ZFIN; ZDB-GENE-040426-1082; rtraf.
DR   eggNOG; KOG4380; Eukaryota.
DR   InParanoid; Q7ZUH1; -.
DR   PhylomeDB; Q7ZUH1; -.
DR   PRO; PR:Q7ZUH1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   InterPro; IPR019265; RTRAF.
DR   PANTHER; PTHR15924; PTHR15924; 1.
DR   Pfam; PF10036; RLL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..242
FT                   /note="RNA transcription, translation and transport factor
FT                   protein"
FT                   /id="PRO_0000331288"
SQ   SEQUENCE   242 AA;  27858 MW;  8F846B27B233E477 CRC64;
     MFRRKLTALE YHNPTGFDCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN IPSSDWPKYF
     EKYLQDVNCP FSVQERQETV DWLLGLAVRF EYGDNVEKYR NCKPVTETND VQKSADPLIN
     LDSNNPDFKA GVLALANLLK IQRHDDYLVM LKAIKILVQE RLTPDAIAKA SQAKEGLPVT
     LDKHILGFDT GDATLNEAAQ VLRLLHIEEL RELQTKINEA IVAVQAIIAD PKTDHRLGKV
     GR