ID   RTRAF_PONAB             Reviewed;         244 AA.
AC   Q5R8I2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=RNA transcription, translation and transport factor protein {ECO:0000250|UniProtKB:Q9Y224};
GN   Name=RTRAF {ECO:0000250|UniProtKB:Q9Y224};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in modulation of mRNA
CC       transcription by Polymerase II. Component of the tRNA-splicing ligase
CC       complex and is required for tRNA ligation. May be required for RNA
CC       transport. {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBUNIT: Homodimer. Interacts with FAM98A (via N- and C-terminus).
CC       Interacts with NIN; which may prevent phosphorylation of NIN. Interacts
CC       with POLR2A. Component of a tRNA-splicing ligase complex.
CC       {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y224}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       perinuclear region {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q9Y224}. Note=May localize at the centrosome
CC       during mitosis. Shuttles between the cytosol and the nucleus: enters
CC       into the nucleus in case of active transcription while it accumulates
CC       in cytosol when transcription level is low.
CC       {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SIMILARITY: Belongs to the RTRAF family. {ECO:0000305}.
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DR   EMBL; CR859770; CAH91928.1; -; mRNA.
DR   RefSeq; NP_001126118.1; NM_001132646.2.
DR   AlphaFoldDB; Q5R8I2; -.
DR   SMR; Q5R8I2; -.
DR   STRING; 9601.ENSPPYP00000006606; -.
DR   Ensembl; ENSPPYT00000034780; ENSPPYP00000041009; ENSPPYG00000037492.
DR   GeneID; 100173074; -.
DR   KEGG; pon:100173074; -.
DR   CTD; 51637; -.
DR   eggNOG; KOG4380; Eukaryota.
DR   GeneTree; ENSGT00390000005163; -.
DR   HOGENOM; CLU_075085_0_0_1; -.
DR   InParanoid; Q5R8I2; -.
DR   OMA; NRKEFAS; -.
DR   OrthoDB; 1239557at2759; -.
DR   TreeFam; TF323606; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   InterPro; IPR019265; RTRAF.
DR   PANTHER; PTHR15924; PTHR15924; 1.
DR   Pfam; PF10036; RLL; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   RNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..244
FT                   /note="RNA transcription, translation and transport factor
FT                   protein"
FT                   /id="PRO_0000089958"
FT   MOD_RES         20
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y224"
FT   MOD_RES         62
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y224"
FT   MOD_RES         98
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y224"
SQ   SEQUENCE   244 AA;  28068 MW;  EB2C3C5577A09A2A CRC64;
     MFRRKLTALD YHNPAGFNCK DETEFRNFIV WLEDQKIRHY KIEDRGNLRN IHSSDWPKFF
     EKYLRDVNCP FKIQDRQEAI DWLLGLAVRL EYGDNAEKYK DLVPDNSKTA DNATKNAEPL
     INLDVNNPDF KAGVMALANL LQIQRHDDYL VMLKAIRILV QERLTQDAVA KANQTKEGLP
     VALDKHILGF DTGDAVLNEA AQILRLLHIE ELRELQTKIN EAIVAVQAII ADPKTDHRLG
     KVGR