ID   RTRAF_XENLA             Reviewed;         240 AA.
AC   Q63ZS0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=RNA transcription, translation and transport factor protein {ECO:0000250|UniProtKB:Q9Y224};
GN   Name=rtraf {ECO:0000250|UniProtKB:Q9Y224};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in modulation of mRNA
CC       transcription by Polymerase II. Component of the tRNA-splicing ligase
CC       complex. {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBUNIT: Homodimer. Component of a tRNA-splicing ligase complex.
CC       {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y224}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       perinuclear region {ECO:0000250|UniProtKB:Q9Y224}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:Q9Y224}. Note=Shuttles between the cytosol and
CC       the nucleus. {ECO:0000250|UniProtKB:Q9Y224}.
CC   -!- SIMILARITY: Belongs to the RTRAF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082840; AAH82840.1; -; mRNA.
DR   RefSeq; NP_001088113.1; NM_001094644.1.
DR   AlphaFoldDB; Q63ZS0; -.
DR   SMR; Q63ZS0; -.
DR   BioGRID; 104895; 2.
DR   IntAct; Q63ZS0; 1.
DR   PRIDE; Q63ZS0; -.
DR   DNASU; 494815; -.
DR   GeneID; 494815; -.
DR   KEGG; xla:494815; -.
DR   CTD; 494815; -.
DR   Xenbase; XB-GENE-17334024; rtraf.L.
DR   OMA; NRKEFAS; -.
DR   OrthoDB; 1239557at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 494815; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0072686; C:mitotic spindle; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0072669; C:tRNA-splicing ligase complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
DR   GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   InterPro; IPR019265; RTRAF.
DR   PANTHER; PTHR15924; PTHR15924; 1.
DR   Pfam; PF10036; RLL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..240
FT                   /note="RNA transcription, translation and transport factor
FT                   protein"
FT                   /id="PRO_0000331289"
SQ   SEQUENCE   240 AA;  27621 MW;  5DD3B3F83BF6DFD2 CRC64;
     MFRRKLQALD YHNPAGFNFK DETEFRNFLV WLEDQKIRHY KIEERGNLRN IHSSEWPAQY
     EKYLNDVNCP FKVQERQESI DWLLGLAVRL EYGDNAAKYQ NAKPYNSDVS KSAEPLINLD
     VNNPDFKAGV MALANLLQIQ RHDDYLMMLK AIRILVQERL SQEAVAKSNS AKEGLPVALD
     KHILGFDTGD AVLNDAARIL RLLHIEELRE LQTKINEAIV AVQAIIADPK TDHRLGKVGR