RTTN_HUMAN
ID RTTN_HUMAN Reviewed; 2226 AA.
AC Q86VV8; Q68CS9; Q6ZRL8; Q6ZTK3; Q86TG4; Q8N8N8; Q8TBQ4; Q96IN9; Q9UFJ4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Rotatin {ECO:0000305};
GN Name=RTTN {ECO:0000312|HGNC:HGNC:18654};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1164-2226 (ISOFORM 1), AND VARIANTS ALA-126 AND
RP SER-1761.
RC TISSUE=Teratocarcinoma, Testis, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-2226 (ISOFORM 4), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2017-2226 (ISOFORM 3).
RC TISSUE=Esophageal carcinoma, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 343-2226 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2069-2226 (ISOFORM 3).
RC TISSUE=Kidney, Pancreas, PNS, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Lymphoblast;
RX PubMed=14654843; DOI=10.1038/nature02166;
RA Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.;
RT "Proteomic characterization of the human centrosome by protein correlation
RT profiling.";
RL Nature 426:570-574(2003).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-811, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [7]
RP SUBCELLULAR LOCATION, FUNCTION, AND VARIANTS MSSP TYR-27 AND PHE-932.
RX PubMed=22939636; DOI=10.1016/j.ajhg.2012.07.008;
RA Kheradmand Kia S., Verbeek E., Engelen E., Schot R., Poot R.A.,
RA de Coo I.F., Lequin M.H., Poulton C.J., Pourfarzad F., Grosveld F.G.,
RA Brehm A., de Wit M.C., Oegema R., Dobyns W.B., Verheijen F.W.,
RA Mancini G.M.;
RT "RTTN mutations link primary cilia function to organization of the human
RT cerebral cortex.";
RL Am. J. Hum. Genet. 91:533-540(2012).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP INTERACTION WITH PPP1R35.
RX PubMed=30168418; DOI=10.7554/elife.37846;
RA Sydor A.M., Coyaud E., Rovelli C., Laurent E., Liu H., Raught B.,
RA Mennella V.;
RT "PPP1R35 is a novel centrosomal protein that regulates centriole length in
RT concert with the microcephaly protein RTTN.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Involved in the genetic cascade that governs left-right
CC specification. Plays a role in the maintenance of a normal ciliary
CC structure. Required for correct asymmetric expression of NODAL, LEFTY
CC and PITX2. {ECO:0000269|PubMed:22939636}.
CC -!- SUBUNIT: Interacts with PPP1R35; this interaction allows the mutual
CC recruitment to the centriole. {ECO:0000269|PubMed:30168418}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000269|PubMed:22939636}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000269|PubMed:14654843}.
CC Note=Colocalizes with the basal bodies at the primary cilium.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86VV8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86VV8-2; Sequence=VSP_029024, VSP_029025;
CC Name=3;
CC IsoId=Q86VV8-3; Sequence=VSP_029030, VSP_029031;
CC Name=4;
CC IsoId=Q86VV8-4; Sequence=VSP_029026, VSP_029027;
CC -!- DISEASE: Microcephaly, short stature, and polymicrogyria with or
CC without seizures (MSSP) [MIM:614833]: A disease characterized by many
CC irregular small gyri in the brain surface and fusion of the molecular
CC layer over multiple small gyri, which gives a festooned appearance to
CC the cortical surface, without abnormal neuronal migration.
CC Polymicrogyria is a heterogeneous disorder, considered to be the result
CC of postmigratory abnormal cortical organization. MSSP patients have
CC moderate to severe intellectual disability, poor speech, dysarthria and
CC seizures. {ECO:0000269|PubMed:22939636}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the rotatin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86583.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87292.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=CAH18659.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK096404; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK126538; BAC86583.1; ALT_INIT; mRNA.
DR EMBL; AK128137; BAC87292.1; ALT_SEQ; mRNA.
DR EMBL; AC011930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC021701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL117635; CAB56025.2; -; mRNA.
DR EMBL; CR749799; CAH18659.1; ALT_INIT; mRNA.
DR EMBL; BC007359; AAH07359.2; -; mRNA.
DR EMBL; BC026879; AAH26879.1; -; mRNA.
DR EMBL; BC046222; AAH46222.2; -; mRNA.
DR EMBL; BC047602; AAH47602.1; -; mRNA.
DR CCDS; CCDS42443.1; -. [Q86VV8-1]
DR PIR; T17335; T17335.
DR RefSeq; NP_001305449.1; NM_001318520.1.
DR RefSeq; NP_775901.3; NM_173630.3. [Q86VV8-1]
DR AlphaFoldDB; Q86VV8; -.
DR SMR; Q86VV8; -.
DR BioGRID; 117418; 15.
DR IntAct; Q86VV8; 5.
DR STRING; 9606.ENSP00000255674; -.
DR iPTMnet; Q86VV8; -.
DR PhosphoSitePlus; Q86VV8; -.
DR BioMuta; RTTN; -.
DR DMDM; 296452975; -.
DR EPD; Q86VV8; -.
DR jPOST; Q86VV8; -.
DR MassIVE; Q86VV8; -.
DR MaxQB; Q86VV8; -.
DR PaxDb; Q86VV8; -.
DR PeptideAtlas; Q86VV8; -.
DR PRIDE; Q86VV8; -.
DR ProteomicsDB; 70074; -. [Q86VV8-1]
DR ProteomicsDB; 70075; -. [Q86VV8-2]
DR ProteomicsDB; 70076; -. [Q86VV8-3]
DR ProteomicsDB; 70077; -. [Q86VV8-4]
DR Antibodypedia; 49105; 26 antibodies from 9 providers.
DR DNASU; 25914; -.
DR Ensembl; ENST00000255674.11; ENSP00000255674.7; ENSG00000176225.15. [Q86VV8-3]
DR Ensembl; ENST00000640769.2; ENSP00000491507.1; ENSG00000176225.15. [Q86VV8-1]
DR GeneID; 25914; -.
DR KEGG; hsa:25914; -.
DR MANE-Select; ENST00000640769.2; ENSP00000491507.1; NM_173630.4; NP_775901.3.
DR UCSC; uc002lkp.4; human. [Q86VV8-1]
DR CTD; 25914; -.
DR DisGeNET; 25914; -.
DR GeneCards; RTTN; -.
DR HGNC; HGNC:18654; RTTN.
DR HPA; ENSG00000176225; Low tissue specificity.
DR MalaCards; RTTN; -.
DR MIM; 610436; gene.
DR MIM; 614833; phenotype.
DR neXtProt; NX_Q86VV8; -.
DR OpenTargets; ENSG00000176225; -.
DR Orphanet; 468631; Microcephalic cortical malformations-short stature due to RTTN deficiency.
DR PharmGKB; PA38622; -.
DR VEuPathDB; HostDB:ENSG00000176225; -.
DR eggNOG; ENOG502QPM7; Eukaryota.
DR GeneTree; ENSGT00640000091535; -.
DR HOGENOM; CLU_001318_0_0_1; -.
DR InParanoid; Q86VV8; -.
DR OMA; IICICSK; -.
DR OrthoDB; 846261at2759; -.
DR PhylomeDB; Q86VV8; -.
DR TreeFam; TF323508; -.
DR PathwayCommons; Q86VV8; -.
DR SignaLink; Q86VV8; -.
DR BioGRID-ORCS; 25914; 439 hits in 1084 CRISPR screens.
DR ChiTaRS; RTTN; human.
DR GenomeRNAi; 25914; -.
DR Pharos; Q86VV8; Tbio.
DR PRO; PR:Q86VV8; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q86VV8; protein.
DR Bgee; ENSG00000176225; Expressed in secondary oocyte and 161 other tissues.
DR ExpressionAtlas; Q86VV8; baseline and differential.
DR Genevisible; Q86VV8; HS.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0007099; P:centriole replication; IBA:GO_Central.
DR GO; GO:0010457; P:centriole-centriole cohesion; IBA:GO_Central.
DR GO; GO:0032053; P:ciliary basal body organization; IBA:GO_Central.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR030791; Rotatin.
DR InterPro; IPR029249; Rotatin_N.
DR PANTHER; PTHR31691; PTHR31691; 1.
DR Pfam; PF14726; RTTN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 4.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cilium; Cytoplasm;
KW Cytoskeleton; Developmental protein; Disease variant; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..2226
FT /note="Rotatin"
FT /id="PRO_0000308612"
FT REGION 295..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 310
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 811
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT VAR_SEQ 601
FT /note="I -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029024"
FT VAR_SEQ 602..2226
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029025"
FT VAR_SEQ 861..879
FT /note="DIKMHAVVKKLCLIDKIIE -> GCRMFGTTMPHTLEEGFMW (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029026"
FT VAR_SEQ 880..2226
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029027"
FT VAR_SEQ 2200
FT /note="F -> P (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_029030"
FT VAR_SEQ 2201..2226
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_029031"
FT VARIANT 27
FT /note="C -> Y (in MSSP; dbSNP:rs201884120)"
FT /evidence="ECO:0000269|PubMed:22939636"
FT /id="VAR_069094"
FT VARIANT 126
FT /note="S -> A (in dbSNP:rs3911730)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_036848"
FT VARIANT 245
FT /note="K -> R (in dbSNP:rs17082206)"
FT /id="VAR_036849"
FT VARIANT 932
FT /note="L -> F (in MSSP; dbSNP:rs318240757)"
FT /evidence="ECO:0000269|PubMed:22939636"
FT /id="VAR_069095"
FT VARIANT 1742
FT /note="H -> R (in dbSNP:rs285227)"
FT /id="VAR_036850"
FT VARIANT 1761
FT /note="F -> S (in dbSNP:rs4891392)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_036851"
FT CONFLICT 241
FT /note="F -> FG (in Ref. 1; AK096404 and 3; CAH18659)"
FT /evidence="ECO:0000305"
FT CONFLICT 385
FT /note="S -> P (in Ref. 3; CAH18659)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="I -> V (in Ref. 3; CAH18659)"
FT /evidence="ECO:0000305"
FT CONFLICT 839
FT /note="T -> A (in Ref. 3; CAH18659)"
FT /evidence="ECO:0000305"
FT CONFLICT 1359
FT /note="E -> G (in Ref. 1; BAC87292)"
FT /evidence="ECO:0000305"
FT CONFLICT 1587
FT /note="S -> G (in Ref. 1; BAC86583)"
FT /evidence="ECO:0000305"
FT CONFLICT 1934
FT /note="L -> P (in Ref. 4; AAH46222)"
FT /evidence="ECO:0000305"
FT CONFLICT 2017
FT /note="L -> V (in Ref. 3; CAB56025)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2226 AA; 248630 MW; B58B776B42B6092B CRC64;
MVLAGLIRKL GHQLAEIRER ALKSILCKIE HNLICYADLI QERQLFLHLL EWFNFPSVPM
KEEVLNLLSR LVKYPPAVQH LVDVGAVEFL SKLRSNVEPN LQAEIDGILD GLFLLPSEVP
ALSSASYQTN QTELSKNPEI LTGYFPQDKS NFQQMEVPPR PVVNQTVKCL KFSTFPWLPL
TTTDRHVLSS NESSLRSSNH TLIWNTCELL KDVIMQDFPA EIFLQRPKIV QSLLSLLKLA
FGDGKHRLAL QSVSCLQQLC MYLRNRLNFH RDPGFFSNKH DTVSQNSSLS YCHEARGTHH
SQNPSPGSSS PRPSVVGRTG QRPRGDGQDW DAASSSGSSS HAHVNSRISV HSPLDMGHID
LPELETEDTL ELQFQQLSLP QFCVSILESA VPLLRTGSRQ VIIRVLELLT EDMTLIGEAI
STDIWDDSSL FGIDMKEKLL LVLGALGETM CYHKSSISLE QPEVMLVHHR MAFISISLFA
VRLLQTLLPV EKASEFLSEP MSTALFLLSL DMPISLEYPN IHEAVVAYLE QLNSENYSIY
KRTAEAVYSI ECTCNFLSDI GKEGEKNLLE LVELADQALR SFSYHQHFPL IKEIISICSK
IWKSAQASPL LQGESQKVLL HMLSHPLPRV KAETYHCCLE ITKECLGVHN VTKPVSSLCN
GIHFLLHPKV LYEISVFGIQ EPESEVNTAA KAILLYLLQG RLMMTALTWN KFIESLCPVI
PILQGYADTE DPLGNCILLL SKASSDTEEM LPCTTRLKSM LRLLLVKKPS VRSLALKLLA
FHLTSEEGAD TKRPLIDARV LSRVTDLFIG KKPIELRLDD RRELVIKLET VEKVYEIFTS
DDVDLVLRKS AAEQLAVIMQ DIKMHAVVKK LCLIDKIIEY LNECVSQDGK VVECLVQPCL
TLLRKVLCGD PVMRVSLSQQ SSLLTVLFRV SLIFHEDCSV VTEVGALFCL LLFDEVSRMD
MWSVNPSNKP SLPSVFSLPV SVFRRYHLPV HVIGHHAVSP YSIVLPLSAD CLALKPVSDM
LRIAWNLSWY HGSDNLLKQM NSETKTQEIL DALKLSTEDI LTLKITHMAS GLQDCLHSIV
QAATHREVRA AVTRMSFYLL NDRLSLKGCP GPCGVTLKSL AWHTALNRFL QVLPACTEDE
KLLIDIIHFL NKLIKEQRKN SSLELLNWIL ELLLRHSANP LLDLLVLTES QAREETDDIR
TAVRQQLQKE LIALFDTLLL NFMEVTDRKC SELLYVFQTQ LALKLLQCLK VTDAPHFYGL
PSLERTLRGM ANLTAFPGWS SHSPLTKPLD ICVKYLSGLL EVITSFYVER GGNAMSFMGK
GVTKSTILCL LHLSHEMMAQ AGSLEWMSLW FLPLGSHSEE HIPTQQGLAW LIPLWVDRDP
EVRFTSLGLG SALTTLETGC VALANSCQNI SGGLWGTVVN ILLDQSECSM VRREAAFILQ
NLLVIPMPTE IIKDYTWQGP CVHDEDSGLS LIGKPALQAL LYHCHFYEHL NQMVKHCYLG
RCMFDLNFSA FDRNSESNDL NGLDDSFKFW RAPSRTSQDR DPSSLSTSET TVAPSLGSTE
FQPLVQSTTL LPEASHDQFV AQGHQESTSP RPPHDSSLSA PLPKLCVFVT PSLLSAMCSL
LDNLLTIAPR DTAKAFRQAH LIELLCSIAD ATLIQTCVQE LRALLPSSPP AEHTQAQVSF
LLEYLSSLSR LLQSCLLVEP DLVIQDELVK PLITNIIGIL TICTKDVLDK ELISAFYHTW
THLFNLLAML LRKAGAITLP FVTVALAKHW TAAIDMFCTC AGLSATCPAL YTASLQFLSV
LLTEEAKGHL QAKSKTHLCC SPTVASLLDD SQENQKSLEQ LSDVILQCYE GKSSKDILKR
VAANALMSLL AVSRRAQKHA LKANLIDNCM EQMKHINAQL NLDSLRPGKA ALKKKEDGVI
KELSIAMQLL RNCLYQNEEC KEAALEAHLV PVLHSLWPWI LMDDSLMQIS LQLLCVYTAN
FPNGCSSLCW SSCGQHPVQA THRGAVSNSL MLCILKLASQ MPLENTTVQQ MVFMLLSNLA
LSHDCKGVIQ KSNFLQNFLS LALPKGGNKH LSNLTILWLK LLLNISSGED GQQMILRLDG
CLDLLTEMSK YKHKSSPLLP LLIFHNVCFS PANKPKILAN EKVITVLAAC LESENQNAQR
IGAAALWALI YNYQKAKTAL KSPSVKRRVD EAYSLAKKTF PNSEANPLNA YYLKCLENLV
QLLNSS
