ID   RTX2_SCHPO              Reviewed;         240 AA.
AC   O94355;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Transcriptional regulatory protein rxt2;
GN   Name=rtx2; ORFNames=SPBC428.06c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   IDENTIFICATION IN THE RPD3C(L) COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=19040720; DOI=10.1186/gb-2008-9-11-r167;
RA   Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C.,
RA   Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.;
RT   "Chromatin Central: towards the comparative proteome by accurate mapping of
RT   the yeast proteomic environment.";
RL   Genome Biol. 9:R167.1-R167.22(2008).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=20537132; DOI=10.1186/gb-2010-11-6-r60;
RA   Han T.X., Xu X.Y., Zhang M.J., Peng X., Du L.L.;
RT   "Global fitness profiling of fission yeast deletion strains by barcode
RT   sequencing.";
RL   Genome Biol. 11:R60.1-R60.13(2010).
CC   -!- FUNCTION: Component of the RPD3C(L) histone deacetylase complex (HDAC)
CC       responsible for the deacetylation of lysine residues on the N-terminal
CC       part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation
CC       gives a tag for epigenetic repression and plays an important role in
CC       transcriptional regulation, cell cycle progression and developmental
CC       events (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RPD3C(L) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- DISRUPTION PHENOTYPE: Leads to sensitivity to camptothecin,
CC       thiabendazole, DNA damaging agents and microtubule depolymerizing
CC       drugs. {ECO:0000269|PubMed:20537132}.
CC   -!- SIMILARITY: Belongs to the RXT2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA22281.2; -; Genomic_DNA.
DR   PIR; T40458; T40458.
DR   RefSeq; NP_595184.2; NM_001021092.2.
DR   AlphaFoldDB; O94355; -.
DR   BioGRID; 277214; 221.
DR   STRING; 4896.SPBC428.06c.1; -.
DR   iPTMnet; O94355; -.
DR   MaxQB; O94355; -.
DR   PaxDb; O94355; -.
DR   PRIDE; O94355; -.
DR   EnsemblFungi; SPBC428.06c.1; SPBC428.06c.1:pep; SPBC428.06c.
DR   GeneID; 2540689; -.
DR   KEGG; spo:SPBC428.06c; -.
DR   PomBase; SPBC428.06c; -.
DR   VEuPathDB; FungiDB:SPBC428.06c; -.
DR   eggNOG; ENOG502S5XA; Eukaryota.
DR   HOGENOM; CLU_1171210_0_0_1; -.
DR   InParanoid; O94355; -.
DR   OMA; EWLDHDN; -.
DR   PRO; PR:O94355; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:1990483; C:Clr6 histone deacetylase complex I''; IPI:PomBase.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0033698; C:Rpd3L complex; IDA:PomBase.
DR   GO; GO:0006338; P:chromatin remodeling; IC:PomBase.
DR   GO; GO:0016575; P:histone deacetylation; IEA:InterPro.
DR   GO; GO:0061188; P:negative regulation of ribosomal DNA heterochromatin assembly; IBA:GO_Central.
DR   GO; GO:0061186; P:negative regulation of silent mating-type cassette heterochromatin assembly; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IC:PomBase.
DR   GO; GO:0061587; P:transfer RNA gene-mediated silencing; IBA:GO_Central.
DR   InterPro; IPR039602; Rxt2.
DR   InterPro; IPR013904; RXT2_N.
DR   PANTHER; PTHR28232; PTHR28232; 2.
DR   Pfam; PF08595; RXT2_N; 1.
PE   1: Evidence at protein level;
KW   Chromatin regulator; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Transcriptional regulatory protein rxt2"
FT                   /id="PRO_0000374023"
SQ   SEQUENCE   240 AA;  27076 MW;  83A65C31A2E493AF CRC64;
     MKQFEEQIER FKQALFEDSD ASDSDSSIGE ALTNRGLKRK KGSKNVYYGC VGNSSGSSID
     IDYYNIGNTK RGVVSHFRRR IDPEWLDHDN PYNDINIAEI MSPLTKPQDL LTHPAISSIF
     EQNYLSILAS SALEIISAEH KYTAHLEQLM VALLGDDPSL PGPPHEVFGI SPEQCRELTI
     TVQEALEKSK EFIRCWTNVR MDLLRAIRFK NKVIAYCQGE DYNGNTQVLS KNESDGKPNS