RU17_DICDI
ID RU17_DICDI Reviewed; 459 AA.
AC Q55FQ0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=U1 small nuclear ribonucleoprotein 70 kDa;
DE Short=U1 snRNP 70 kDa;
DE Short=U1-70K;
DE Short=snRNP70;
GN Name=snrnp70; Synonyms=snrp70; ORFNames=DDB_G0268004;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the splicing of pre-mRNA by binding to the stem loop
CC I region of U1-snRNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AAFI02000003; EAL73455.1; -; Genomic_DNA.
DR RefSeq; XP_647483.1; XM_642391.1.
DR AlphaFoldDB; Q55FQ0; -.
DR SMR; Q55FQ0; -.
DR STRING; 44689.DDB0233134; -.
DR PaxDb; Q55FQ0; -.
DR PRIDE; Q55FQ0; -.
DR EnsemblProtists; EAL73455; EAL73455; DDB_G0268004.
DR GeneID; 8616290; -.
DR KEGG; ddi:DDB_G0268004; -.
DR dictyBase; DDB_G0268004; snrp70.
DR eggNOG; KOG0113; Eukaryota.
DR HOGENOM; CLU_596458_0_0_1; -.
DR InParanoid; Q55FQ0; -.
DR OMA; GVAKFMA; -.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q55FQ0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR GO; GO:0005685; C:U1 snRNP; ISS:UniProtKB.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:0043484; P:regulation of RNA splicing; ISS:UniProtKB.
DR GO; GO:0008380; P:RNA splicing; ISS:dictyBase.
DR CDD; cd12236; RRM_snRNP70; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034143; snRNP70_RRM.
DR InterPro; IPR022023; U1snRNP70_N.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF12220; U1snRNP70_N; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Coiled coil; mRNA processing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding.
FT CHAIN 1..459
FT /note="U1 small nuclear ribonucleoprotein 70 kDa"
FT /id="PRO_0000327475"
FT DOMAIN 99..178
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 185..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 53436 MW; 7C33D3D8550C8B0C CRC64;
MAFLPPNLKI MFNPRHPPPF LPPPPPSNLP PYTGLRDYLS IFTDPSNEEP FKKEHIENLE
EKREKKRKLK ISENDERISK SLKAWDPYSN SETTGDPYKT IFVSRISYKT TQQKLEFEFG
QFGPIKSLFL VKDSNNPEKH TGYAFIEFER ERDMKAAYKQ ADGMKIDDRR IVVDIERGRV
IKNWKPRKFG GGLGNTRAGG VDVNQTFSGR EMSESREKEK EREKEKEKEK ERMEKMKKRD
GGLSSNGNRS NGISSGSGGS GGDRGDRGDR DRGDRGDRSD RSDRDRERGR GDRDHRGSGG
ERERERDQRD RGGDRGGDRG DRSDRGRSDR GDRGDRSDRG RDDRERGRDD RGDRGRDDRR
GGSDRDRDRG SRDDRGDRDD RSDRGRDDRR GGSDRDHRID ERRRDQRDYG SISDAHFDHF
QYQPQQHHHH QQNHQSHHNQ PHPERVNRDY SMISNENGF
