RU17_SCHPO
ID RU17_SCHPO Reviewed; 261 AA.
AC O13829;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=U1 small nuclear ribonucleoprotein 70 kDa homolog;
DE Short=U1 70K;
DE Short=U1 snRNP 70 kDa homolog;
DE Short=U1-70K;
DE AltName: Full=U1 small nuclear ribonucleoprotein usp101;
DE Short=U1 snRNP protein usp101;
GN Name=usp101 {ECO:0000312|EMBL:CAB11649.1};
GN Synonyms=snp1 {ECO:0000312|EMBL:CAB11649.1}; ORFNames=SPAC19A8.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAB11649.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3] {ECO:0000305}
RP FUNCTION, IDENTIFICATION IN U1 SNRNP COMPLEX, IDENTIFICATION BY MASS
RP SPECTROMETRY, AND INTERACTION WITH U1 SNRNA.
RX PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA Jaensch L., Kaeufer N.F.;
RT "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT three essential organism-specific proteins.";
RL Nucleic Acids Res. 35:1391-1401(2007).
CC -!- FUNCTION: Involved in nuclear mRNA splicing (By similarity). Essential
CC for growth. {ECO:0000250|UniProtKB:Q00916,
CC ECO:0000269|PubMed:17264129}.
CC -!- SUBUNIT: Component of the spliceosome, where it is associated with
CC snRNP U1. Associates with U1 snRNA. {ECO:0000269|PubMed:17264129}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329670; CAB11649.1; -; Genomic_DNA.
DR PIR; T37948; T37948.
DR RefSeq; NP_593779.1; NM_001019208.2.
DR AlphaFoldDB; O13829; -.
DR SMR; O13829; -.
DR BioGRID; 278922; 28.
DR DIP; DIP-59803N; -.
DR IntAct; O13829; 1.
DR STRING; 4896.SPAC19A8.13.1; -.
DR iPTMnet; O13829; -.
DR MaxQB; O13829; -.
DR PaxDb; O13829; -.
DR PRIDE; O13829; -.
DR EnsemblFungi; SPAC19A8.13.1; SPAC19A8.13.1:pep; SPAC19A8.13.
DR GeneID; 2542461; -.
DR KEGG; spo:SPAC19A8.13; -.
DR PomBase; SPAC19A8.13; usp101.
DR VEuPathDB; FungiDB:SPAC19A8.13; -.
DR eggNOG; KOG0113; Eukaryota.
DR HOGENOM; CLU_045151_4_1_1; -.
DR InParanoid; O13829; -.
DR OMA; QEQANYK; -.
DR PhylomeDB; O13829; -.
DR PRO; PR:O13829; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000243; C:commitment complex; ISO:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR GO; GO:0003729; F:mRNA binding; ISO:PomBase.
DR GO; GO:0017069; F:snRNA binding; IBA:GO_Central.
DR GO; GO:0030619; F:U1 snRNA binding; ISO:PomBase.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; ISO:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd12236; RRM_snRNP70; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034143; snRNP70_RRM.
DR InterPro; IPR022023; U1snRNP70_N.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF12220; U1snRNP70_N; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..261
FT /note="U1 small nuclear ribonucleoprotein 70 kDa homolog"
FT /id="PRO_0000339243"
FT DOMAIN 100..178
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 192..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 30198 MW; E1F9F4EE5E09CA49 CRC64;
MAEKLPAPLL ALFAPRPPLR YLPPMDVPPE KRSTPRVSGI AKYLKYAQSH DQQYHPTESL
EEKRLRLRDE KQKQQRERLR SMIKVWDPDH DRHVIGDPYK TMFLSRLSYD TKESDIEREF
TRYGPIERIR VVRNKVTGKS MGYAFVVFER ERDLKVAYKA SAGLMLNGRR IVVDVERGRT
VKGWLPRKLG GGLGGRHYTK ERPRRERGSR FRGDSGFRGG YRGGFRKSSG GGSRFGRGPT
RSSHSSDYGG RDSSPKRRRY N
