RU1A_SCHPO
ID RU1A_SCHPO Reviewed; 249 AA.
AC O74968;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=U1 small nuclear ribonucleoprotein usp102;
DE Short=U1 snRNP protein usp102;
GN Name=usp102 {ECO:0000312|EMBL:CAA19287.1};
GN Synonyms=mud1 {ECO:0000312|EMBL:CAA19287.1}; ORFNames=SPBC4B4.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA19287.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3] {ECO:0000305}
RP IDENTIFICATION IN U1 SNRNP BY MASS SPECTROMETRY.
RX PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA Jaensch L., Kaeufer N.F.;
RT "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT three essential organism-specific proteins.";
RL Nucleic Acids Res. 35:1391-1401(2007).
CC -!- FUNCTION: Involved in nuclear mRNA splicing.
CC {ECO:0000250|UniProtKB:P32605}.
CC -!- SUBUNIT: Component of the spliceosome where it is associated with snRNP
CC U1. {ECO:0000269|PubMed:17264129}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the RRM U1 A/B'' family. {ECO:0000255}.
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DR EMBL; CU329671; CAA19287.1; -; Genomic_DNA.
DR PIR; T40479; T40479.
DR RefSeq; NP_596424.1; NM_001022343.2.
DR AlphaFoldDB; O74968; -.
DR SMR; O74968; -.
DR BioGRID; 277382; 328.
DR STRING; 4896.SPBC4B4.07c.1; -.
DR iPTMnet; O74968; -.
DR MaxQB; O74968; -.
DR PaxDb; O74968; -.
DR EnsemblFungi; SPBC4B4.07c.1; SPBC4B4.07c.1:pep; SPBC4B4.07c.
DR GeneID; 2540865; -.
DR KEGG; spo:SPBC4B4.07c; -.
DR PomBase; SPBC4B4.07c; usp102.
DR VEuPathDB; FungiDB:SPBC4B4.07c; -.
DR eggNOG; KOG4206; Eukaryota.
DR HOGENOM; CLU_041869_0_1_1; -.
DR InParanoid; O74968; -.
DR OMA; NQTIYVN; -.
DR PhylomeDB; O74968; -.
DR PRO; PR:O74968; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; IC:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..249
FT /note="U1 small nuclear ribonucleoprotein usp102"
FT /id="PRO_0000338448"
FT DOMAIN 26..105
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 174..247
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 28339 MW; 44BCDC1B89A9037C CRC64;
MDPQTNSHQE VQQPSPKETD SQTPSETLYI RNIEEKIRLT MLKRILEHLF GSYGKVIDVQ
ARKTLRMRGQ AFVVFDNLEN ASRALKDLQG YPLYGKPMMI QYSKSKSDII VQRESPEEIE
TRKKDRKNRR EMLKRTSALQ PAAPKPTHKK PVPKRNVGAE RKSTINEDLL PPNKVLLLQN
IPQEVNADVL TQIFEAFSGF QEVRMVPGRR GIAFVEYDSD REATVAKNGT TGMSLSGNQI
KVTFARKAS
