ID   BCRH_RICPR              Reviewed;         407 AA.
AC   Q9ZCV6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized transporter RP603;
GN   OrderedLocusNames=RP603;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC       family. {ECO:0000305}.
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DR   EMBL; AJ235272; CAA15047.1; -; Genomic_DNA.
DR   PIR; E71665; E71665.
DR   RefSeq; NP_220971.1; NC_000963.1.
DR   RefSeq; WP_004598986.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZCV6; -.
DR   SMR; Q9ZCV6; -.
DR   STRING; 272947.RP603; -.
DR   EnsemblBacteria; CAA15047; CAA15047; CAA15047.
DR   GeneID; 57569728; -.
DR   KEGG; rpr:RP603; -.
DR   PATRIC; fig|272947.5.peg.621; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_47_1_5; -.
DR   OMA; PLYRWSR; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..407
FT                   /note="Uncharacterized transporter RP603"
FT                   /id="PRO_0000281083"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   407 AA;  45750 MW;  8A5EC5A0BEEF6EC6 CRC64;
     MKIIAKIPAW MLLCLFILSP TTETIYTSGL PSLTRCFSID GCITQMTSTL YFLGFAVGIL
     SLGRLSDIYG RRPIVLLGLF IYIVSSIISI FSFNIEMLMI ARFIQAFGVS VGSVIGQSMA
     RDSYQGAELS YVYAILSPWL LFIPALGSYI GGYIIEYLSW HYVFIFFSLA GTILLALYYQ
     ILPETNYYIA FSQSSKYFEV FNIIIKDKML WLYAFIIGAF NGIYYGFFIE APFILIDQMR
     VLPSFYGKLA FLLSFASIFG GFLGGYLIKK RQVYDKKVMS IGFIFSLCGC ILFAVDSFIL
     EFILVSNVFA IAMIFMPMMI HMIGHSLLIA ITLRYALEDY ATVTGTAGSI FGAIYYVVIA
     SVTYCVSKIH GETISNFSLL CLVLSISSVI SFYYICLLYK KKSIIIN