ID   RU1C_ANODA              Reviewed;         151 AA.
AC   E3X5D6; W5JLZ9;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1-C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1C {ECO:0000255|HAMAP-Rule:MF_03153};
GN   ORFNames=AND_004369 {ECO:0000312|EMBL:ETN63905.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=43151;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT   the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
CC   -!- FUNCTION: Component of the spliceosomal U1 snRNP, which is essential
CC       for recognition of the pre-mRNA 5' splice-site and the subsequent
CC       assembly of the spliceosome. U1-C is directly involved in initial 5'
CC       splice-site recognition for both constitutive and regulated alternative
CC       splicing. The interaction with the 5' splice-site seems to precede
CC       base-pairing between the pre-mRNA and the U1 snRNA. Stimulates
CC       commitment or early (E) complex formation by stabilizing the base
CC       pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SUBUNIT: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2,
CC       D3, E, F and G that assemble in a heptameric protein ring on the Sm
CC       site of the small nuclear RNA to form the core snRNP, and at least 3 U1
CC       snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1
CC       snRNA and the 5' splice-site region of the pre-mRNA.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SIMILARITY: Belongs to the U1 small nuclear ribonucleoprotein C family.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
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DR   EMBL; ADMH02001150; ETN63905.1; -; Genomic_DNA.
DR   AlphaFoldDB; E3X5D6; -.
DR   STRING; 43151.ADAC004369-PA; -.
DR   VEuPathDB; VectorBase:ADAC004369; -.
DR   eggNOG; KOG3454; Eukaryota.
DR   HOGENOM; CLU_079697_3_1_1; -.
DR   InParanoid; E3X5D6; -.
DR   OMA; ILPRPMM; -.
DR   OrthoDB; 1594407at2759; -.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0000243; C:commitment complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005685; C:U1 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:UniProtKB-UniRule.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030619; F:U1 snRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IEA:UniProtKB-UniRule.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03153; U1_C; 1.
DR   InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR013085; U1-CZ_Znf_C2H2.
DR   InterPro; IPR017340; U1_snRNP-C.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   PANTHER; PTHR31148; PTHR31148; 1.
DR   Pfam; PF06220; zf-U1; 1.
DR   PIRSF; PIRSF037969; U1_snRNP-C; 1.
DR   SMART; SM00451; ZnF_U1; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50171; ZF_MATRIN; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..151
FT                   /note="U1 small nuclear ribonucleoprotein C"
FT                   /id="PRO_0000414259"
FT   ZN_FING         4..36
FT                   /note="Matrin-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03153"
SQ   SEQUENCE   151 AA;  16520 MW;  3869E98621A53E37 CRC64;
     MPKYYCDYCD TYLTHDSPSV RKTHCTGRKH KDNVKFYYQK WMEEQAQHLI DATTAAYKAG
     KIAQNPFTAG PPKPNISIPP PTMNMPPRPG IIPGMPAGAP PLLMGPNGPL PPPMMGMRPP
     PMMVPTMGMP PMGLGMRPPV MSAAPPQLNP K