ID   BCRH_RICTY              Reviewed;         409 AA.
AC   Q68WD6;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Uncharacterized transporter RT0591;
GN   OrderedLocusNames=RT0591;
OS   Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=257363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA   McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA   Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA   Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT   of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC       family. {ECO:0000305}.
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DR   EMBL; AE017197; AAU04056.1; -; Genomic_DNA.
DR   RefSeq; WP_011191037.1; NC_006142.1.
DR   AlphaFoldDB; Q68WD6; -.
DR   SMR; Q68WD6; -.
DR   STRING; 257363.RT0591; -.
DR   EnsemblBacteria; AAU04056; AAU04056; RT0591.
DR   KEGG; rty:RT0591; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_47_1_5; -.
DR   OMA; MMFPQIV; -.
DR   OrthoDB; 1452500at2; -.
DR   Proteomes; UP000000604; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..409
FT                   /note="Uncharacterized transporter RT0591"
FT                   /id="PRO_0000281084"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   409 AA;  45873 MW;  C041363D9CC31C71 CRC64;
     MKIIVKIPVW MLLSLFILSP TTETIYTSGL PSLTKYFSID GCITQITSTL YFLGFAVGIL
     SLGRLSDIYG RRPIVLLGLF IYIVSSIISI FSVNIEMLMI ARFIQAFGVS VGSVIGQSMA
     RDSYQGAELS YVYAILSPWL LFIPSLGSYI GGYIIEYSSW HYVFVFFSLI GTILLALYYK
     ILPETNYYID FSQSSKYFEV FNIIIKDKIL WLYAFIIGAF NGIYYGFFIE APFILIDKMK
     VLPSFYGKLA FLLSFSAIFG GFLGGYLIKK RQVHDKKVMS IGFIFSLCGC ILFVVNAFIL
     EFILVSNGLA ISMIFVPMMI HIIGHSLLIP ITLRYALEDY AKVTGTAGSI FGAIYYIVIA
     AVTYCVSKIH GETISNFSLL CLVSSISSVI SFYYICILYK KKSIVANEK