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RU1C_NEUCR
ID   RU1C_NEUCR              Reviewed;         216 AA.
AC   Q1K7T5;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1-C {ECO:0000255|HAMAP-Rule:MF_03153};
DE            Short=U1C {ECO:0000255|HAMAP-Rule:MF_03153};
GN   ORFNames=NCU01341;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the spliceosomal U1 snRNP, which is essential
CC       for recognition of the pre-mRNA 5' splice-site and the subsequent
CC       assembly of the spliceosome. U1-C is directly involved in initial 5'
CC       splice-site recognition for both constitutive and regulated alternative
CC       splicing. The interaction with the 5' splice-site seems to precede
CC       base-pairing between the pre-mRNA and the U1 snRNA. Stimulates
CC       commitment or early (E) complex formation by stabilizing the base
CC       pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SUBUNIT: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2,
CC       D3, E, F and G that assemble in a heptameric protein ring on the Sm
CC       site of the small nuclear RNA to form the core snRNP, and at least 3 U1
CC       snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1
CC       snRNA and the 5' splice-site region of the pre-mRNA.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153}.
CC   -!- SIMILARITY: Belongs to the U1 small nuclear ribonucleoprotein C family.
CC       {ECO:0000255|HAMAP-Rule:MF_03153}.
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DR   EMBL; CM002240; EAA32191.1; -; Genomic_DNA.
DR   RefSeq; XP_961427.1; XM_956334.2.
DR   AlphaFoldDB; Q1K7T5; -.
DR   SMR; Q1K7T5; -.
DR   STRING; 5141.EFNCRP00000004143; -.
DR   EnsemblFungi; EAA32191; EAA32191; NCU01341.
DR   GeneID; 3877555; -.
DR   KEGG; ncr:NCU01341; -.
DR   VEuPathDB; FungiDB:NCU01341; -.
DR   HOGENOM; CLU_079697_2_0_1; -.
DR   InParanoid; Q1K7T5; -.
DR   OMA; FLTHDST; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0000243; C:commitment complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:UniProtKB-UniRule.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030627; F:pre-mRNA 5'-splice site binding; IBA:GO_Central.
DR   GO; GO:0030619; F:U1 snRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IBA:GO_Central.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03153; U1_C; 1.
DR   InterPro; IPR000690; Matrin/U1-C_Znf_C2H2.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR013085; U1-CZ_Znf_C2H2.
DR   InterPro; IPR017340; U1_snRNP-C.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   PANTHER; PTHR31148; PTHR31148; 1.
DR   Pfam; PF06220; zf-U1; 1.
DR   SMART; SM00451; ZnF_U1; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS50171; ZF_MATRIN; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..216
FT                   /note="U1 small nuclear ribonucleoprotein C"
FT                   /id="PRO_0000414291"
FT   ZN_FING         4..36
FT                   /note="Matrin-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03153"
FT   REGION          70..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..89
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..208
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  21527 MW;  D029E2DA62575FEA CRC64;
     MPKFFCDYCD VYLTHDSMSV RKAHNSGRNH LRNVVDYYQQ IGHEKAQSVI DSITSSYAAE
     GQAHANPMLP QNQPGGVPPG LGFPPPGAGV PPFPPFPGGM PPPFPGMPGG APVPPPGAFG
     APGVPGGIPP PGAPGARGMP PMPPFPGMPG APAGIPGVPP PMPGPGGLPF PPPGGLPFPP
     PGAGNFPFPP PGAPGAFPGM PPFGAPGQGP PGADKR
 
 
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