ID   BCR_HAEIN               Reviewed;         398 AA.
AC   P45123;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Bicyclomycin resistance protein homolog;
GN   Name=bcr; OrderedLocusNames=HI_1242;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in sulfonamide (sulfathiazole) and bicyclomycin
CC       resistance. Probable membrane translocase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Bcr/CmlA
CC       family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22894.1; -; Genomic_DNA.
DR   PIR; E64112; E64112.
DR   RefSeq; NP_439398.1; NC_000907.1.
DR   RefSeq; WP_005694302.1; NC_000907.1.
DR   AlphaFoldDB; P45123; -.
DR   SMR; P45123; -.
DR   STRING; 71421.HI_1242; -.
DR   EnsemblBacteria; AAC22894; AAC22894; HI_1242.
DR   KEGG; hin:HI_1242; -.
DR   PATRIC; fig|71421.8.peg.1294; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_47_0_6; -.
DR   OMA; YFFMLNI; -.
DR   PhylomeDB; P45123; -.
DR   BioCyc; HINF71421:G1GJ1-1272-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IBA:GO_Central.
DR   InterPro; IPR004812; Efflux_drug-R_Bcr/CmlA.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00710; efflux_Bcr_CflA; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..398
FT                   /note="Bicyclomycin resistance protein homolog"
FT                   /id="PRO_0000173316"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   398 AA;  43459 MW;  F681C5C654675216 CRC64;
     MNQQKSTFIF ILTLGILSML PPFGVDMYLP SFLEIAKDLD VSPEQVQHTL TSFAYGMAFG
     QLFWGPFGDS FGRKPIILLG VIVGALTALV LTEINSVGNF TALRFVQGFF GAAPVVLSGA
     LLRDLFSKDQ LSKVMSTITL VFMLAPLVAP IIGGYIVKFF HWHAIFYVIS LVGLLAAALV
     FFIIPETHKK ENRIPLRLNI IARNFLLLWK QKEVLGYMFA ASFSFGGLFA FVTAGSIVYI
     GIYGVPVDQF GYFFMMNIVT MIFASFLNSR FVTKVGAETM LRIALAIQFL SGMWLILTAL
     LDLGFWPMAI GVAFFVGPNP VISSNAMASA LERCPQMAGT ANSLIGSVRF AVGAIMGSLV
     ASMKMDTAAP MLFTMGACVV ISVLAYYFLT SRNLKSRG