ID   RU2A_ASHGO              Reviewed;         237 AA.
AC   Q755D2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
GN   Name=LEA1; OrderedLocusNames=AFL109W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS53265.1; -; Genomic_DNA.
DR   RefSeq; NP_985441.1; NM_210795.1.
DR   AlphaFoldDB; Q755D2; -.
DR   SMR; Q755D2; -.
DR   STRING; 33169.AAS53265; -.
DR   EnsemblFungi; AAS53265; AAS53265; AGOS_AFL109W.
DR   GeneID; 4621668; -.
DR   KEGG; ago:AGOS_AFL109W; -.
DR   eggNOG; KOG1644; Eukaryota.
DR   HOGENOM; CLU_061027_3_0_1; -.
DR   OMA; CHLEDYR; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..237
FT                   /note="U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074179"
FT   REPEAT          53..74
FT                   /note="LRR 1"
FT   REPEAT          75..95
FT                   /note="LRR 2"
FT   REPEAT          97..118
FT                   /note="LRR 3"
FT   DOMAIN          132..170
FT                   /note="LRRCT"
FT   REGION          161..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   237 AA;  26866 MW;  F4374F5265B9DB6E CRC64;
     MKLTPASILE APVYYADHIH GKYDVDKVVI LRDCGYVSEN EIMPQTLKLL PERTNIVDFT
     NNELEELPPL GHNDTVHTLL LSRNRLGRLD ASRLPRYLVN LNLAMNRFEK FEQLQGLRSA
     PKTLKNLNLR GNVICHKEQY RETVIALCPQ LAVLDGERVR QAERQAAPQN EKTDTPTEGP
     QPVALQATSE KELQLMDHVV NKMDKDTLED IKQQLAKATT LAEIERLEKL LSGGVIQ