ID   RU2A_ASPFU              Reviewed;         253 AA.
AC   Q4WV66;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
GN   Name=lea1; ORFNames=AFUA_5G11000;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000003; EAL91510.1; -; Genomic_DNA.
DR   RefSeq; XP_753548.1; XM_748455.1.
DR   AlphaFoldDB; Q4WV66; -.
DR   SMR; Q4WV66; -.
DR   STRING; 746128.CADAFUBP00005729; -.
DR   EnsemblFungi; EAL91510; EAL91510; AFUA_5G11000.
DR   GeneID; 3510775; -.
DR   KEGG; afm:AFUA_5G11000; -.
DR   VEuPathDB; FungiDB:Afu5g11000; -.
DR   eggNOG; KOG1644; Eukaryota.
DR   HOGENOM; CLU_061027_1_0_1; -.
DR   InParanoid; Q4WV66; -.
DR   OMA; PNYREYM; -.
DR   OrthoDB; 1447031at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..253
FT                   /note="U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074180"
FT   REPEAT          19..40
FT                   /note="LRR 1"
FT   REPEAT          41..62
FT                   /note="LRR 2"
FT   REPEAT          63..84
FT                   /note="LRR 3"
FT   REPEAT          87..108
FT                   /note="LRR 4"
FT   DOMAIN          121..159
FT                   /note="LRRCT"
FT   REGION          228..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28803 MW;  F1869E30F0EAD5A0 CRC64;
     MRLTVELIQN SLSYINPLKD RELDLRGHKI PTIENLGIAK DQDAIDFTDN DISSLGNFPF
     FPRLHTLLLA RNRVKHIQPT IASTIPNLTT LVLTANNMAE LADLDPLRNL TRLTHLVLLE
     NPVTRKEHYR YWVIWRIPSV RFLDYQKVKD AERAKAKELF GTAEEPTALA SKIMGIKSRT
     FDVPSGGAER APADKAVRVK LTEKERKRVE KMIREARSLQ EITRLEKELN EGRIPGGALD
     AGEDSEDENQ MQT