ID   RU2A_CAEEL              Reviewed;         253 AA.
AC   Q9BLB6; E0AFQ0;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Probable U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
DE   AltName: Full=Masculinization of germline protein 2;
DE   AltName: Full=Spliceosome-associated protein mog-2;
GN   Name=mog-2; Synonyms=sap-1; ORFNames=H20J04.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH RNP-3, SUBCELLULAR
RP   LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21504747; DOI=10.1016/j.ydbio.2011.04.001;
RA   Zanetti S., Meola M., Bochud A., Puoti A.;
RT   "Role of the C. elegans U2 snRNP protein MOG-2 in sex determination,
RT   meiosis, and splice site selection.";
RL   Dev. Biol. 354:232-241(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: This protein is associated with sn-RNP U2. It helps the A'
CC       protein to bind stem loop IV of U2 snRNA. Required maternally for early
CC       embryonic development and zygotically for germline and somatic
CC       development. Has a role in the switch from mitosis to meiosis. Might
CC       function in alternative splicing. {ECO:0000269|PubMed:21504747}.
CC   -!- SUBUNIT: Interacts with rnp-3. {ECO:0000269|PubMed:21504747}.
CC   -!- INTERACTION:
CC       Q9BLB6; Q21323: rnp-3; NbExp=3; IntAct=EBI-3890918, EBI-3890921;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21504747}.
CC       Note=Expressed in the transition zone and pachytene region of mitotic
CC       nuclei.
CC   -!- DISRUPTION PHENOTYPE: Reduced rate of growth. Embryonic lethal. Mog-2
CC       and rnp-3 double mutants show arrested larval development at L2,
CC       without showing signs of oogenesis or spermatogenesis and increased
CC       rates of embryonic lethality. {ECO:0000269|PubMed:21504747}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HM852593; ADL39791.1; -; mRNA.
DR   EMBL; FO080156; CCD61684.1; -; Genomic_DNA.
DR   RefSeq; NP_494763.1; NM_062362.3.
DR   AlphaFoldDB; Q9BLB6; -.
DR   SMR; Q9BLB6; -.
DR   BioGRID; 39123; 7.
DR   IntAct; Q9BLB6; 2.
DR   STRING; 6239.H20J04.8; -.
DR   EPD; Q9BLB6; -.
DR   PaxDb; Q9BLB6; -.
DR   PeptideAtlas; Q9BLB6; -.
DR   EnsemblMetazoa; H20J04.8.1; H20J04.8.1; WBGene00003390.
DR   GeneID; 173767; -.
DR   KEGG; cel:CELE_H20J04.8; -.
DR   UCSC; H20J04.8.1; c. elegans.
DR   CTD; 173767; -.
DR   WormBase; H20J04.8; CE20974; WBGene00003390; mog-2.
DR   eggNOG; KOG1644; Eukaryota.
DR   GeneTree; ENSGT00940000153289; -.
DR   HOGENOM; CLU_061027_1_0_1; -.
DR   InParanoid; Q9BLB6; -.
DR   OMA; PNYREYM; -.
DR   OrthoDB; 1447031at2759; -.
DR   PhylomeDB; Q9BLB6; -.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q9BLB6; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003390; Expressed in embryo and 4 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0005686; C:U2 snRNP; IDA:WormBase.
DR   GO; GO:0030620; F:U2 snRNA binding; IDA:WormBase.
DR   GO; GO:0040022; P:feminization of hermaphroditic germ-line; IMP:WormBase.
DR   GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IGI:WormBase.
DR   GO; GO:0000389; P:mRNA 3'-splice site recognition; IMP:WormBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IDA:WormBase.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Nucleus; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding.
FT   CHAIN           1..253
FT                   /note="Probable U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074176"
FT   REPEAT          20..41
FT                   /note="LRR 1"
FT   REPEAT          43..64
FT                   /note="LRR 2"
FT   REPEAT          65..86
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          123..161
FT                   /note="LRRCT"
FT   REGION          163..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28865 MW;  6BB6A3B2E417E127 CRC64;
     MVRLTTELFA ERPQFVNSVN MREINLRGQK IPVIENMGVT RDQFDVIDLT DNDIRKLDNF
     PTFSRLNTLY LHNNRINYIA PDIATKLPNL KTLALTNNNI CELGDIEPLA ECKKLEYVTF
     IGNPITHKDN YRMYMIYKLP TVRVIDFNRV RLTEREAAKK MFKGKSGKKA RDAIQKSVHT
     EDPSEIEPNE NSSGGGARLT DEDREKIKEA IKNAKSLSEV NYLQSILASG KVPEKGWNRQ
     MDQNGADGEA MES