ID   RU2A_CANAL              Reviewed;         233 AA.
AC   Q5A449; A0A1D8PMD9;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
GN   Name=LEA1; OrderedLocusNames=CAALFM_C405750CA;
GN   ORFNames=CaO19.1260, CaO19.8845;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
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DR   EMBL; CP017626; AOW29305.1; -; Genomic_DNA.
DR   RefSeq; XP_716568.1; XM_711475.1.
DR   AlphaFoldDB; Q5A449; -.
DR   SMR; Q5A449; -.
DR   STRING; 237561.Q5A449; -.
DR   PRIDE; Q5A449; -.
DR   GeneID; 3641807; -.
DR   KEGG; cal:CAALFM_C405750CA; -.
DR   CGD; CAL0000184113; LEA1.
DR   VEuPathDB; FungiDB:C4_05750C_A; -.
DR   eggNOG; KOG1644; Eukaryota.
DR   HOGENOM; CLU_061027_3_0_1; -.
DR   InParanoid; Q5A449; -.
DR   OMA; PNYREYM; -.
DR   OrthoDB; 1447031at2759; -.
DR   PRO; PR:Q5A449; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..233
FT                   /note="U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074181"
FT   REPEAT          20..40
FT                   /note="LRR 1"
FT   REPEAT          42..63
FT                   /note="LRR 2"
FT   REPEAT          65..86
FT                   /note="LRR 3"
FT   REPEAT          89..110
FT                   /note="LRR 4"
FT   DOMAIN          122..160
FT                   /note="LRRCT"
SQ   SEQUENCE   233 AA;  27168 MW;  4B207D7EBAADBD1C CRC64;
     MRLTAQVINE APEILNPEGK LTLLLRDLQI TELENLAITQ NKYQVIDLSN NDLISLGNIP
     KRFNNLQCLL LSNNNISYID DESFPSDNHI TSITLFNNNI YQFQKSFKDK FPKLETLILL
     GNPITEMENY RYFIIWLIPS LKVLDFKKVK QAERKTSEDM FGTNRDEFNS LAQQMFKNEN
     TEIKLDGKSD RQVKNFVKKM TDEERQQLLK KLETATSIEE IERIENDLKE GAV