ID   RU2A_CANGA              Reviewed;         266 AA.
AC   Q6FV04;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
GN   Name=LEA1; OrderedLocusNames=CAGL0E05786g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
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DR   EMBL; CR380951; CAG58859.1; -; Genomic_DNA.
DR   RefSeq; XP_445940.1; XM_445940.1.
DR   AlphaFoldDB; Q6FV04; -.
DR   SMR; Q6FV04; -.
DR   STRING; 5478.XP_445940.1; -.
DR   EnsemblFungi; CAG58859; CAG58859; CAGL0E05786g.
DR   GeneID; 2887467; -.
DR   KEGG; cgr:CAGL0E05786g; -.
DR   CGD; CAL0128902; CAGL0E05786g.
DR   VEuPathDB; FungiDB:CAGL0E05786g; -.
DR   eggNOG; KOG1644; Eukaryota.
DR   HOGENOM; CLU_061027_3_0_1; -.
DR   InParanoid; Q6FV04; -.
DR   OMA; CHLEDYR; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0005686; C:U2 snRNP; IEA:EnsemblFungi.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..266
FT                   /note="U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074182"
FT   REPEAT          30..51
FT                   /note="LRR 1"
FT   REPEAT          53..74
FT                   /note="LRR 2"
FT   REPEAT          75..95
FT                   /note="LRR 3"
FT   REPEAT          97..118
FT                   /note="LRR 4"
FT   DOMAIN          132..170
FT                   /note="LRRCT"
SQ   SEQUENCE   266 AA;  29808 MW;  C078E3D7CE36B411 CRC64;
     MKFTPGAVED APSYYVDHDN GKYNTQKCVI LRNLGLEGDD IAMPASLNHL AKPTHILDLT
     NNDLVFFPDL HHRDDIETLL LSKNRLMVLD AALLPSKLKS LSLAFNGIEN FETLIPLSHC
     PSTVRDLVLI GNPICHLSEY RQRILALVPS LEVLDFKLVS QAEKAQAVKD HVAVMKKIKE
     DNRQIHQRKK KALAAEVDGK NTFGRNTKSL TEAAKVTKPR DKTIEVMNTV VGKLTEEKKK
     KIREQLANAS SMEELERLER LLTGGV