RU2A_DEBHA
ID RU2A_DEBHA Reviewed; 238 AA.
AC Q6BT60;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=U2 small nuclear ribonucleoprotein A';
DE Short=U2 snRNP A';
GN Name=LEA1; OrderedLocusNames=DEHA2D03278g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC {ECO:0000305}.
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DR EMBL; CR382136; CAG86745.2; -; Genomic_DNA.
DR RefSeq; XP_458610.2; XM_458610.1.
DR AlphaFoldDB; Q6BT60; -.
DR SMR; Q6BT60; -.
DR STRING; 4959.XP_458610.2; -.
DR EnsemblFungi; CAG86745; CAG86745; DEHA2D03278g.
DR GeneID; 2901395; -.
DR KEGG; dha:DEHA2D03278g; -.
DR VEuPathDB; FungiDB:DEHA2D03278g; -.
DR eggNOG; KOG1644; Eukaryota.
DR HOGENOM; CLU_061027_3_0_1; -.
DR InParanoid; Q6BT60; -.
DR OMA; PNYREYM; -.
DR OrthoDB; 1447031at2759; -.
DR Proteomes; UP000000599; Chromosome D.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0030620; F:U2 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR044640; RU2A.
DR PANTHER; PTHR10552; PTHR10552; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..238
FT /note="U2 small nuclear ribonucleoprotein A'"
FT /id="PRO_0000074183"
FT REPEAT 19..40
FT /note="LRR 1"
FT REPEAT 42..63
FT /note="LRR 2"
FT REPEAT 64..84
FT /note="LRR 3"
FT REPEAT 89..110
FT /note="LRR 4"
FT DOMAIN 123..161
FT /note="LRRCT"
SQ SEQUENCE 238 AA; 27203 MW; 4E1FE852F6891728 CRC64;
MRLTSQVLSD APTIINPEKQ VTLSLRSLKI PYLENLGITK DTYEVIDLTD NELIELSNFP
RLKNLKVLLV GNNNITGIND DKLPNNLPHL QSISFIHNNI SKFSDVRILC RFKNLSNITF
IENPITDSPN YRYFIVWLIP TLKVLDFSKV KQKELVKAKE LFGESIDDPS ELALSMLEDI
STTESRKNQI SSKDIRNLQD VGKKLTDEDK AKLLQELETA DSVEDIERIE RALHNGHM
