ID   RU2A_NEUCR              Reviewed;         252 AA.
AC   Q7S9P4;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=U2 small nuclear ribonucleoprotein A';
DE            Short=U2 snRNP A';
GN   Name=lea-1; ORFNames=NCU06622;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC       {ECO:0000305}.
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DR   EMBL; CM002239; EAA33128.1; -; Genomic_DNA.
DR   RefSeq; XP_962364.1; XM_957271.2.
DR   AlphaFoldDB; Q7S9P4; -.
DR   SMR; Q7S9P4; -.
DR   STRING; 5141.EFNCRP00000006315; -.
DR   EnsemblFungi; EAA33128; EAA33128; NCU06622.
DR   GeneID; 3878512; -.
DR   KEGG; ncr:NCU06622; -.
DR   VEuPathDB; FungiDB:NCU06622; -.
DR   HOGENOM; CLU_061027_1_0_1; -.
DR   InParanoid; Q7S9P4; -.
DR   OMA; PNYREYM; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044640; RU2A.
DR   PANTHER; PTHR10552; PTHR10552; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   3: Inferred from homology;
KW   Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Repeat; Spliceosome.
FT   CHAIN           1..252
FT                   /note="U2 small nuclear ribonucleoprotein A'"
FT                   /id="PRO_0000074185"
FT   REPEAT          41..62
FT                   /note="LRR 1"
FT   REPEAT          63..84
FT                   /note="LRR 2"
FT   REPEAT          87..108
FT                   /note="LRR 3"
FT   DOMAIN          121..159
FT                   /note="LRRCT"
SQ   SEQUENCE   252 AA;  28083 MW;  199A0C628A57AAEC CRC64;
     MRLTADLINN SLSYLNPLKE REIDLRGHRI PAIENLGVAG PHDAIDFTDN DIQVLGNFPL
     SPRIRTLLLA RNRIAQIQST LPNATPNLKN LVLASNNIGE LADLEVLGRF PRLTHLVLTD
     NPVTKKENYR YWVLWLCPQV RFLDYVKVKD AERQKAKELF GTADEPTELA KTIKGIKSKT
     FDVGASSANG AAGSGPSSKL SRLKLTEKEK KKLQDLIKKA DSLEEIIRLE KALNEGRLPP
     GIIAEDDDAM EE