RU2A_YARLI
ID RU2A_YARLI Reviewed; 230 AA.
AC Q6C417;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=U2 small nuclear ribonucleoprotein A';
DE Short=U2 snRNP A';
GN Name=LEA1; OrderedLocusNames=YALI0E30569g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the U2 small nuclear ribonucleoprotein A family.
CC {ECO:0000305}.
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DR EMBL; CR382131; CAG80199.1; -; Genomic_DNA.
DR RefSeq; XP_504595.1; XM_504595.1.
DR AlphaFoldDB; Q6C417; -.
DR SMR; Q6C417; -.
DR STRING; 4952.CAG80199; -.
DR EnsemblFungi; CAG80199; CAG80199; YALI0_E30569g.
DR GeneID; 2912068; -.
DR KEGG; yli:YALI0E30569g; -.
DR VEuPathDB; FungiDB:YALI0_E30569g; -.
DR HOGENOM; CLU_061027_3_0_1; -.
DR InParanoid; Q6C417; -.
DR OMA; CHLEDYR; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR GO; GO:0030620; F:U2 snRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR044640; RU2A.
DR PANTHER; PTHR10552; PTHR10552; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Leucine-rich repeat; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Repeat; Spliceosome.
FT CHAIN 1..230
FT /note="U2 small nuclear ribonucleoprotein A'"
FT /id="PRO_0000074188"
FT REPEAT 15..36
FT /note="LRR 1"
FT REPEAT 48..69
FT /note="LRR 2"
FT REPEAT 71..92
FT /note="LRR 3"
FT REPEAT 93..114
FT /note="LRR 4"
FT REPEAT 115..136
FT /note="LRR 5"
FT DOMAIN 149..187
FT /note="LRRCT"
SQ SEQUENCE 230 AA; 26161 MW; BA0F75A46B2BC098 CRC64;
MNFWWLKFDD ASTESLRNNI FTNNSITKNM RLNADTILNA QSYINPIGDR ELNLRGLQIP
VIENLGVTED HYTSLDLSDN EIRVMGGFPR LETLRTLLLS KNRITQINDV KNIAKLETLV
LTQNGIATLG ALESLKSLVN LTAITLDGNP VQHVPRYRSY MISILPSLRM LDFQRVTQKE
RDEAEAMEFD VVPVTETDNL SAVDKAELRE RLKNATTIQE IEEIEAMLKV
