ID   RU2B_DICDI              Reviewed;         241 AA.
AC   Q54J05;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=U2 small nuclear ribonucleoprotein B'';
DE            Short=U2 snRNP B'';
GN   Name=snrpb2; ORFNames=DDB_G0288391;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC       spliceosome. Associated with sn-RNP U2, where it contributes to the
CC       binding of stem loop IV of U2 snRNA. {ECO:0000250|UniProtKB:P08579}.
CC   -!- SUBUNIT: Identified in the spliceosome B complex. Identified in the
CC       spliceosome C complex. {ECO:0000250|UniProtKB:P08579}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P08579}.
CC   -!- SIMILARITY: Belongs to the RRM U1 A/B'' family. {ECO:0000305}.
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DR   EMBL; AAFI02000111; EAL63221.1; -; Genomic_DNA.
DR   RefSeq; XP_636725.1; XM_631633.1.
DR   AlphaFoldDB; Q54J05; -.
DR   SMR; Q54J05; -.
DR   STRING; 44689.DDB0233135; -.
DR   PaxDb; Q54J05; -.
DR   PRIDE; Q54J05; -.
DR   EnsemblProtists; EAL63221; EAL63221; DDB_G0288391.
DR   GeneID; 8626602; -.
DR   KEGG; ddi:DDB_G0288391; -.
DR   dictyBase; DDB_G0288391; snrpB2.
DR   eggNOG; KOG4206; Eukaryota.
DR   HOGENOM; CLU_041869_1_1_1; -.
DR   InParanoid; Q54J05; -.
DR   OMA; ADINPNH; -.
DR   PhylomeDB; Q54J05; -.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q54J05; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR   GO; GO:0030619; F:U1 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..241
FT                   /note="U2 small nuclear ribonucleoprotein B''"
FT                   /id="PRO_0000327959"
FT   DOMAIN          12..91
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          167..241
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          99..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  27302 MW;  DF1F4C5608607254 CRC64;
     METESADIPP NQTLYVNNLY EKISKKKLIE QLLLLFSKYG PILEIVGSKS LKMRGQAFIV
     FKDITSASNA LREMNGFNFL DRPMKIQYCK SKSDAVSKLD GTYMEKKRER EENDKKGSNK
     KQDRKSTGQQ QQQQKRPGAP TSTTSTTSPT TSNGTVSLQP RDDPPNKTLF VENLPDKCDS
     MMLSMLFSQF QGFKEVHMVE SKKGIAFIEF EDEIKSGFAM TNLQHFKVTP EKPMVVSFAA
     Q