RUAS1_HUMAN
ID RUAS1_HUMAN Reviewed; 236 AA.
AC Q66K80; Q8NA07;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Putative uncharacterized protein RUSC1-AS1;
DE AltName: Full=RUSC1 antisense RNA 1;
DE AltName: Full=RUSC1 antisense gene protein 1;
GN Name=RUSC1-AS1; Synonyms=C1orf104;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q66K80; P54252: ATXN3; NbExp=3; IntAct=EBI-10248967, EBI-946046;
CC Q66K80; P55212: CASP6; NbExp=3; IntAct=EBI-10248967, EBI-718729;
CC Q66K80; P06307: CCK; NbExp=3; IntAct=EBI-10248967, EBI-6624398;
CC Q66K80; P28329-3: CHAT; NbExp=3; IntAct=EBI-10248967, EBI-25837549;
CC Q66K80; P99999: CYCS; NbExp=3; IntAct=EBI-10248967, EBI-446479;
CC Q66K80; P22607: FGFR3; NbExp=3; IntAct=EBI-10248967, EBI-348399;
CC Q66K80; P28799: GRN; NbExp=3; IntAct=EBI-10248967, EBI-747754;
CC Q66K80; P06396: GSN; NbExp=3; IntAct=EBI-10248967, EBI-351506;
CC Q66K80; P30519: HMOX2; NbExp=3; IntAct=EBI-10248967, EBI-712096;
CC Q66K80; P04792: HSPB1; NbExp=3; IntAct=EBI-10248967, EBI-352682;
CC Q66K80; P42858: HTT; NbExp=6; IntAct=EBI-10248967, EBI-466029;
CC Q66K80; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10248967, EBI-10975473;
CC Q66K80; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10248967, EBI-21591415;
CC Q66K80; P25788: PSMA3; NbExp=3; IntAct=EBI-10248967, EBI-348380;
CC Q66K80; P62826: RAN; NbExp=3; IntAct=EBI-10248967, EBI-286642;
CC Q66K80; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10248967, EBI-396669;
CC Q66K80; O76024: WFS1; NbExp=3; IntAct=EBI-10248967, EBI-720609;
CC Q66K80; Q9Y649; NbExp=3; IntAct=EBI-10248967, EBI-25900580;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66K80-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66K80-2; Sequence=VSP_020778, VSP_020779;
CC -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
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DR EMBL; AK093295; BAC04124.1; -; mRNA.
DR EMBL; AL139410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062571; AAH62571.1; -; mRNA.
DR EMBL; BC080538; AAH80538.1; -; mRNA.
DR AlphaFoldDB; Q66K80; -.
DR BioGRID; 129918; 5.
DR IntAct; Q66K80; 20.
DR iPTMnet; Q66K80; -.
DR PhosphoSitePlus; Q66K80; -.
DR BioMuta; HGNC:26680; -.
DR PRIDE; Q66K80; -.
DR ProteomicsDB; 65961; -. [Q66K80-1]
DR ProteomicsDB; 65962; -. [Q66K80-2]
DR GeneCards; RUSC1-AS1; -.
DR HGNC; HGNC:26680; RUSC1-AS1.
DR MalaCards; RUSC1-AS1; -.
DR neXtProt; NX_Q66K80; -.
DR PharmGKB; PA142672488; -.
DR InParanoid; Q66K80; -.
DR OrthoDB; 1066656at2759; -.
DR PathwayCommons; Q66K80; -.
DR SignaLink; Q66K80; -.
DR ChiTaRS; RUSC1-AS1; human.
DR Pharos; Q66K80; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q66K80; protein.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..236
FT /note="Putative uncharacterized protein RUSC1-AS1"
FT /id="PRO_0000251895"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 119..180
FT /note="VCPFSPHSSPSFSHHRTLSLFISPAPLSCPAPRAQVHRSTPMGRALLTRVLL
FT EPLRPWACPR -> GPTTLSQAPSGSGTVLEWPVADTEPPASCICCPGCQCQFCRSHWG
FT PQRGQGTLQSCTLKPAR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020778"
FT VAR_SEQ 181..236
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_020779"
FT VARIANT 231
FT /note="R -> S (in dbSNP:rs16836822)"
FT /id="VAR_050704"
SQ SEQUENCE 236 AA; 24494 MW; 307FC5F853D67313 CRC64;
MEPGGSENAA ALWISEGGRG PGRGPGPEWT SRSLLPQSGP ALQPTPYSQR KGPRETHPDA
LKGGGGWGWG NTQSLSGECR KGVGAGEEKD GAAVSLSTPH LLAASAGLQP APSPLGTAVC
PFSPHSSPSF SHHRTLSLFI SPAPLSCPAP RAQVHRSTPM GRALLTRVLL EPLRPWACPR
LPRSPPGGAQ SGRGGALAQP TLRCAAAPLR AWAWRSSDPP PAFSVFCHPP RGFDIS
