RUBP1_ARATH
ID RUBP1_ARATH Reviewed; 226 AA.
AC Q9LSS7;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=NEDD8-specific protease 1;
DE EC=3.4.22.-;
DE AltName: Full=Deneddylase-1;
GN Name=NEDP1; Synonyms=DEN1; OrderedLocusNames=At5g60190; ORFNames=F15L12.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim C.J., Chen H., Cheuk R., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16920872; DOI=10.1104/pp.106.085415;
RA Colby T., Matthai A., Boeckelmann A., Stuible H.P.;
RT "SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis.";
RL Plant Physiol. 142:318-332(2006).
CC -!- FUNCTION: Processes the pre-form of the ubiquitin-like protein
CC NEDD8/RUB1. Has the capacity to discriminate between NEDD8/RUB1 and
CC ubiquitin. Has no SUMO protease activity.
CC {ECO:0000269|PubMed:16920872}.
CC -!- SIMILARITY: Belongs to the peptidase C48 family. {ECO:0000305}.
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DR EMBL; AB026632; BAA97500.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97291.1; -; Genomic_DNA.
DR EMBL; BT012189; AAS76283.1; -; mRNA.
DR EMBL; AK221465; BAD94571.1; -; mRNA.
DR RefSeq; NP_200827.1; NM_125412.4.
DR AlphaFoldDB; Q9LSS7; -.
DR SMR; Q9LSS7; -.
DR STRING; 3702.AT5G60190.1; -.
DR MEROPS; C48.A03; -.
DR PaxDb; Q9LSS7; -.
DR PRIDE; Q9LSS7; -.
DR ProteomicsDB; 226675; -.
DR DNASU; 836141; -.
DR EnsemblPlants; AT5G60190.1; AT5G60190.1; AT5G60190.
DR GeneID; 836141; -.
DR Gramene; AT5G60190.1; AT5G60190.1; AT5G60190.
DR KEGG; ath:AT5G60190; -.
DR Araport; AT5G60190; -.
DR TAIR; locus:2144020; AT5G60190.
DR eggNOG; KOG3246; Eukaryota.
DR HOGENOM; CLU_043678_3_0_1; -.
DR InParanoid; Q9LSS7; -.
DR OMA; LLDPPNW; -.
DR OrthoDB; 1313098at2759; -.
DR PhylomeDB; Q9LSS7; -.
DR PRO; PR:Q9LSS7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LSS7; baseline and differential.
DR Genevisible; Q9LSS7; AT.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0019784; F:deNEDDylase activity; IDA:TAIR.
DR GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR InterPro; IPR044613; Nep1/2-like.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003653; Peptidase_C48_C.
DR PANTHER; PTHR46468; PTHR46468; 1.
DR Pfam; PF02902; Peptidase_C48; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50600; ULP_PROTEASE; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Protease; Reference proteome; Thiol protease;
KW Ubl conjugation pathway.
FT CHAIN 1..226
FT /note="NEDD8-specific protease 1"
FT /id="PRO_0000395975"
SQ SEQUENCE 226 AA; 25684 MW; FCA3AC54596F88B1 CRC64;
MGNTSDDDKI LSYEDVVLRR SDLDILNGPI FLNDRVIEFY LSFLSTVHSS TTISLIPPSI
AFWISNCPDT EYLKDFMKPL NLRDKDLLIL PVNDNSNVEV AEGGLHWSLL VYYKEANTFV
HHDSYMGVNR WSAKQLFKAV SPFVSNGDAS YKECTDTPQQ KNGYDCGVFL LATARVICEW
FSSGGMKNRD ELWFANVKET VPDLVNHLRE EILALIKKLM SESVSK
