ID   BCS1_DANRE              Reviewed;         420 AA.
AC   Q7ZV60;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Mitochondrial chaperone BCS1;
DE   AltName: Full=BCS1-like protein;
GN   Name=bcs1l; ORFNames=zgc:56205;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Chaperone necessary for the assembly of mitochondrial
CC       respiratory chain complex III. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. BCS1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY394959; AAQ94586.1; -; mRNA.
DR   EMBL; BC045990; AAH45990.1; -; mRNA.
DR   RefSeq; NP_957476.2; NM_201182.2.
DR   AlphaFoldDB; Q7ZV60; -.
DR   SMR; Q7ZV60; -.
DR   STRING; 7955.ENSDARP00000015141; -.
DR   PaxDb; Q7ZV60; -.
DR   Ensembl; ENSDART00000022246; ENSDARP00000015141; ENSDARG00000012295.
DR   GeneID; 394157; -.
DR   KEGG; dre:394157; -.
DR   CTD; 617; -.
DR   ZFIN; ZDB-GENE-040426-938; bcs1l.
DR   eggNOG; KOG0743; Eukaryota.
DR   GeneTree; ENSGT00390000005415; -.
DR   HOGENOM; CLU_010189_6_2_1; -.
DR   InParanoid; Q7ZV60; -.
DR   OMA; EWRQFGH; -.
DR   OrthoDB; 532729at2759; -.
DR   PhylomeDB; Q7ZV60; -.
DR   TreeFam; TF315009; -.
DR   PRO; PR:Q7ZV60; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000012295; Expressed in granulocyte and 26 other tissues.
DR   ExpressionAtlas; Q7ZV60; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IBA:GO_Central.
DR   GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR014851; BCS1_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF08740; BCS1_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01024; BCS1_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..420
FT                   /note="Mitochondrial chaperone BCS1"
FT                   /id="PRO_0000084774"
FT   TOPO_DOM        1..15
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..420
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   BINDING         230..237
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        84
FT                   /note="M -> T (in Ref. 2; AAH45990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="I -> V (in Ref. 2; AAH45990)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   420 AA;  47492 MW;  855330AC4B747035 CRC64;
     MTLSDFIGAL KDNPYFGAGF GLVGVGTALA VARKGAQVGM IFFRRHYMIT LEVPSKDKSY
     HWLLSWITKH AKHTQHLSVE TSYMQHESGK VHTQFDFHPS PGNHIIWYGR KWIRVERVRE
     KQMMDLHTGT PWESVTFTAL GRDRQTFFNI LQEARELALK QEEGRTVMYT AMGAEWRPFG
     FPRRRRPLSS VVLESGVAER IVDDVKEFIG NPKWYTDRGI PYRRGYLLYG PPGCGKSSFI
     TALAGELGYS ICLMSLSDRS LSDDRLNHLL SVAPQQSIIL LEDVDAAFVS RELLPTENPL
     AYQGMGRLTF SGLLNALDGV ASSEARIVFM TTNFIERLDP ALVRPGRVDL KQYVGHCSHW
     QLTQMFRRFY PQESAAEADH FSEQALAAHT DLSAAQVQGH FMLYKTDPAG AIKNIAEIKD