BCS1_SCHPO
ID BCS1_SCHPO Reviewed; 449 AA.
AC Q9P6Q3; P78787;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Probable mitochondrial chaperone bcs1;
DE AltName: Full=BCS1-like protein;
GN ORFNames=SPAC644.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 31-449.
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
CC -!- FUNCTION: Chaperone necessary for the assembly of mitochondrial
CC respiratory chain complex III.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. BCS1 subfamily.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAB90134.1; -; Genomic_DNA.
DR EMBL; D89136; BAA13798.1; -; mRNA.
DR PIR; T42406; T42406.
DR RefSeq; NP_593875.1; NM_001019305.2.
DR AlphaFoldDB; Q9P6Q3; -.
DR SMR; Q9P6Q3; -.
DR BioGRID; 280077; 9.
DR STRING; 4896.SPAC644.07.1; -.
DR MaxQB; Q9P6Q3; -.
DR PaxDb; Q9P6Q3; -.
DR EnsemblFungi; SPAC644.07.1; SPAC644.07.1:pep; SPAC644.07.
DR GeneID; 2543663; -.
DR KEGG; spo:SPAC644.07; -.
DR PomBase; SPAC644.07; -.
DR VEuPathDB; FungiDB:SPAC644.07; -.
DR eggNOG; KOG0743; Eukaryota.
DR HOGENOM; CLU_010189_6_2_1; -.
DR InParanoid; Q9P6Q3; -.
DR OMA; EWRQFGH; -.
DR PhylomeDB; Q9P6Q3; -.
DR PRO; PR:Q9P6Q3; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; ISS:PomBase.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:PomBase.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR014851; BCS1_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF08740; BCS1_N; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01024; BCS1_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00674; AAA; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Chaperone; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..449
FT /note="Probable mitochondrial chaperone bcs1"
FT /id="PRO_0000084776"
FT TOPO_DOM 1..20
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..449
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT BINDING 249..256
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 113
FT /note="I -> F (in Ref. 2; BAA13798)"
FT /evidence="ECO:0000305"
FT CONFLICT 412
FT /note="F -> L (in Ref. 2; BAA13798)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 49856 MW; D111D04B3764B87D CRC64;
MDNIGAADAA TSSGISGLLS GNSFLGAGIG LMGFGAGLAI LRRGLISGAS LVKRRMLVSV
EIPSKEKSYN AFLHWMSTVP KRYSNQLAVE SNRQLKMPQN AREKPDKQVA NRIFSLVPGP
GKHYIKYKKC WIQVERERSN RLQDLTTGTP WETITLTTLS RDRGIFSELL LEAQKFMQSA
QKNKTTIYTA WATEWKPFGH PRSKRMLSSV VLESNVKKMI TDDVHDFLRN SQWYDTRGIP
YRRGYLLYGP PGSGKTSFLY ALAGELDYDI CVLNLAEKGL TDDRLNHLLS NVPPKAVVLL
EDVDSAFQGR ERSGEVGFHA NVTFSGLLNA LDGVTSSDER IIFMTTNHPE KLDPALVRPG
RVDVKAYLGN ATPEQVREMF TRFYGHSPEM ADDLSDIVCP KNTSMASLQG LFVMNKSSPA
DAVDMAKELP DNPPSTPFSF NVHRKSLSV
