RUFY2_MOUSE
ID RUFY2_MOUSE Reviewed; 606 AA.
AC Q8R4C2; Q69ZH1;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=RUN and FYVE domain-containing protein 2;
DE AltName: Full=Leucine zipper FYVE-finger protein;
DE Short=LZ-FYVE;
GN Name=Rufy2; Synonyms=Kiaa1537;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RC TISSUE=Embryo;
RX PubMed=11506704; DOI=10.1089/104454901750361460;
RA Dunkelberg J.C., Gutierrez-Hartmann A.;
RT "LZ-FYVE: a novel developmental stage-specific leucine zipper, FYVE-finger
RT protein.";
RL DNA Cell Biol. 20:403-412(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=11877430; DOI=10.1074/jbc.m111933200;
RA Yang J., Kim O., Wu J., Qiu Y.;
RT "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain
RT containing protein RUFY1. A possible role of Etk in regulation of vesicle
RT trafficking.";
RL J. Biol. Chem. 277:30219-30226(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- SUBUNIT: Interacts with BMX. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11506704}.
CC -!- DEVELOPMENTAL STAGE: Expressed only at embryonic stages. Present at 12
CC dpc in primordial lung, cartilage and otic capsule (at protein level).
CC {ECO:0000269|PubMed:11506704}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32473.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF484555; AAM18673.1; -; mRNA.
DR EMBL; AK173195; BAD32473.1; ALT_INIT; mRNA.
DR CCDS; CCDS48582.1; -.
DR RefSeq; NP_081701.2; NM_027425.3.
DR AlphaFoldDB; Q8R4C2; -.
DR SMR; Q8R4C2; -.
DR BioGRID; 214046; 1.
DR STRING; 10090.ENSMUSP00000113429; -.
DR iPTMnet; Q8R4C2; -.
DR PhosphoSitePlus; Q8R4C2; -.
DR MaxQB; Q8R4C2; -.
DR PaxDb; Q8R4C2; -.
DR PRIDE; Q8R4C2; -.
DR ProteomicsDB; 256808; -.
DR Antibodypedia; 45205; 83 antibodies from 20 providers.
DR DNASU; 70432; -.
DR Ensembl; ENSMUST00000119567; ENSMUSP00000113429; ENSMUSG00000020070.
DR GeneID; 70432; -.
DR KEGG; mmu:70432; -.
DR UCSC; uc007fjn.1; mouse.
DR CTD; 55680; -.
DR MGI; MGI:1917682; Rufy2.
DR VEuPathDB; HostDB:ENSMUSG00000020070; -.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000155595; -.
DR HOGENOM; CLU_014576_3_1_1; -.
DR InParanoid; Q8R4C2; -.
DR OMA; IRHDECI; -.
DR OrthoDB; 753155at2759; -.
DR PhylomeDB; Q8R4C2; -.
DR TreeFam; TF323904; -.
DR BioGRID-ORCS; 70432; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Rufy2; mouse.
DR PRO; PR:Q8R4C2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8R4C2; protein.
DR Bgee; ENSMUSG00000020070; Expressed in rostral migratory stream and 222 other tissues.
DR ExpressionAtlas; Q8R4C2; baseline and differential.
DR Genevisible; Q8R4C2; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; ISO:MGI.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; SSF140741; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..606
FT /note="RUN and FYVE domain-containing protein 2"
FT /id="PRO_0000245831"
FT DOMAIN 37..169
FT /note="RUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT ZN_FING 540..598
FT /note="FYVE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT COILED 210..267
FT /evidence="ECO:0000255"
FT COILED 294..515
FT /evidence="ECO:0000255"
FT BINDING 546
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 549
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 562
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 565
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 570
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 573
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 590
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT BINDING 593
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00091"
FT CONFLICT 208
FT /note="Y -> C (in Ref. 2; AAM18673)"
FT /evidence="ECO:0000305"
FT CONFLICT 435
FT /note="I -> V (in Ref. 2; AAM18673)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 606 AA; 70093 MW; 741EE7EA1E0A4EF2 CRC64;
MATKDPTAVE RANLLNMAKL SIKGLIESAL SFGRTLDSDY PPLQQFFVVM EHCLKHGLKG
RKSFLSYNKT IWGPLELVEK LYPEAEEIGA SVRDLPGLKT PLGRARAWLR LALMQKKMAD
YLRCLIIQRE LLSEFYEYHA LMMEEEGAVI VGLLVGLNVI DANLCVKGED LDSQVGVIDF
SMYLKNEEEI GNKERNVQIA AILDQKNYVE ELNRQLNSTV SSLHSRVDSL EKSNTKLIEE
LAIAKNNIIK LQEENHQLRS ENELILMRTR QHLEVTKVDV ETELQTYKHS RQGLDEMYND
ARRQLRDESQ LRQDVENELS VQVGMKHEME LAMKLLEKDI HEKQDTLIGL RQQLEEVKAI
NIEMYQRLQG SEDGLKEKNE IIARLEEKTN KITTAMRQLE QRLQQAEKAQ KEAEAEDEKY
AQECLSQSDS LQRQISQKEQ QLVQLETDLK IEKEWRQTLQ EDLQKEKDVL SHLRHETQKV
ISLKKEFLNL QDENQQLKRI YQEQEQALQE LGSKLCESKL KIDDIKEANK ALQGLVWLKD
KDATHCKLCE KEFSLSKRKH HCRNCGEIFC NACSDNELPL PSSPKPVRVC DSCHAMLIQR
CSSNMP
