ID   RUGA_PELSA              Reviewed;          19 AA.
AC   P84912;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Rugosin A-like peptide;
OS   Pelophylax saharicus (Sahara frog) (Rana saharica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=70019;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:16269346};
RX   PubMed=16269346; DOI=10.1016/j.peptides.2005.03.008;
RA   Marenah L., Flatt P.R., Orr D.F., Shaw C., Abdel-Wahab Y.H.A.;
RT   "Isolation and structural characterization of novel Rugosin A-like
RT   insulinotropic peptide from the skin secretions of Rana saharica frog.";
RL   Peptides 26:2117-2123(2005).
CC   -!- FUNCTION: Stimulates insulin release by BRIN-BD11 cells in vitro. Has
CC       antibacterial activity. {ECO:0000250|UniProtKB:P80954,
CC       ECO:0000269|PubMed:16269346}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16269346}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:16269346}.
CC   -!- MASS SPECTROMETRY: Mass=1892.6; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:16269346};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P84912; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..19
FT                   /note="Rugosin A-like peptide"
FT                   /evidence="ECO:0000269|PubMed:16269346"
FT                   /id="PRO_0000248509"
FT   DISULFID        13..19
FT                   /evidence="ECO:0000250|UniProtKB:P80954"
SQ   SEQUENCE   19 AA;  1893 MW;  E1E6BE508508FD52 CRC64;
     KGAAKGLLEV ASCKLSKSC