ID   RUGB_GLARU              Reviewed;          33 AA.
AC   P80955;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Rugosin-B;
OS   Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX   NCBI_TaxID=8410;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=7612013; DOI=10.1006/bbrc.1995.1963;
RA   Suzuki S., Ohe Y., Kagegawa T., Tatemoto K.;
RT   "Isolation and characterization of novel antimicrobial peptides, rugosins
RT   A, B and C, from the skin of the frog, Rana rugosa.";
RL   Biochem. Biophys. Res. Commun. 212:249-254(1995).
CC   -!- FUNCTION: Shows antibacterial activity against both Gram-negative and
CC       Gram-positive bacteria.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P80955; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..33
FT                   /note="Rugosin-B"
FT                   /id="PRO_0000044663"
FT   DISULFID        27..33
SQ   SEQUENCE   33 AA;  3516 MW;  51FFC8E1641FF536 CRC64;
     SLFSLIKAGA KFLGKNLLKQ GAQYAACKVS KEC