RUGC_GLARU
ID RUGC_GLARU Reviewed; 37 AA.
AC P80956;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Rugosin-C;
OS Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Glandirana.
OX NCBI_TaxID=8410;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Skin secretion;
RX PubMed=7612013; DOI=10.1006/bbrc.1995.1963;
RA Suzuki S., Ohe Y., Kagegawa T., Tatemoto K.;
RT "Isolation and characterization of novel antimicrobial peptides, rugosins
RT A, B and C, from the skin of the frog, Rana rugosa.";
RL Biochem. Biophys. Res. Commun. 212:249-254(1995).
CC -!- FUNCTION: Has antibacterial activity against Gram-positive bacteria.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P80956; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR012521; Antimicrobial_frog_2.
DR Pfam; PF08023; Antimicrobial_2; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..37
FT /note="Rugosin-C"
FT /id="PRO_0000044664"
FT DISULFID 31..37
SQ SEQUENCE 37 AA; 3816 MW; BA88B97B7FC4CFDE CRC64;
GILDSFKQFA KGVGKDLIKG AAQGVLSTMS CKLAKTC
