ID   RUN3A_BOVIN             Reviewed;         441 AA.
AC   Q17QK1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=RUN domain-containing protein 3A;
GN   Name=RUNDC3A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as an effector of RAP2A in neuronal cells.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the GTP-bound form of RAP2A. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RUNDC3 family. {ECO:0000305}.
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DR   EMBL; BC118315; AAI18316.1; -; mRNA.
DR   RefSeq; NP_001069790.1; NM_001076322.1.
DR   AlphaFoldDB; Q17QK1; -.
DR   SMR; Q17QK1; -.
DR   STRING; 9913.ENSBTAP00000002119; -.
DR   PaxDb; Q17QK1; -.
DR   PRIDE; Q17QK1; -.
DR   Ensembl; ENSBTAT00000002119; ENSBTAP00000002119; ENSBTAG00000001615.
DR   GeneID; 614322; -.
DR   KEGG; bta:614322; -.
DR   CTD; 10900; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001615; -.
DR   VGNC; VGNC:34218; RUNDC3A.
DR   eggNOG; KOG4381; Eukaryota.
DR   GeneTree; ENSGT00940000158922; -.
DR   HOGENOM; CLU_045987_0_0_1; -.
DR   InParanoid; Q17QK1; -.
DR   OMA; MSEYIAT; -.
DR   OrthoDB; 714315at2759; -.
DR   TreeFam; TF323904; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000001615; Expressed in temporal cortex and 89 other tissues.
DR   ExpressionAtlas; Q17QK1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IBA:GO_Central.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF140741; SSF140741; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..441
FT                   /note="RUN domain-containing protein 3A"
FT                   /id="PRO_0000324154"
FT   DOMAIN          52..184
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT   REGION          1..293
FT                   /note="Interaction with RAP2A"
FT                   /evidence="ECO:0000250"
FT   REGION          211..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          367..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          262..317
FT                   /evidence="ECO:0000255"
FT   MOD_RES         210
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         227
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         411
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         414
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
SQ   SEQUENCE   441 AA;  49462 MW;  F9AAD1D27ABC1968 CRC64;
     MEASFVQTTM ALGLSSKKAS SRNVAVERRN LITVCRFSVK TLLEKYTTEP IDDSSEEFVN
     FAAILEQILS HRFKGPVSWF SSDGQRGFWD YIRLACSKVP NNCVSSIENM ENISTARAKG
     RAWIRVALME KRMSEYITTA LRDTRTTRRF YDSGAIMMRE EATVLTGMLI GLSAIDFSFC
     LKGEVLDGKT PVVIDYTPYL KFTQSYDYLT DEEERHSAES STSEDNSPEH PYLPLVTDED
     SWYSKWHKME QKFRIVYAQK GYLEELVRLR ESQLKDLEAE NRRLQLQLEE AAAQNQREKR
     ELEGVILELQ EQLTGLIPGD HAPLAQGSKD LTTRLVNQWP SLGTLSGAEG ANNPKLYRRH
     SFMSTEPLSA EASLSSDSQR LGEGKRDEEP WGPIGKDPTP SMLGLCGSLA SIPSCKSLAS
     FKSNECLVSD SPEGSPALSP S