RUN3A_DANRE
ID RUN3A_DANRE Reviewed; 428 AA.
AC A7YDW0; Q7ZT23;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=RUN domain-containing protein 3A;
DE AltName: Full=Rap2-interacting protein;
DE Short=Rap2ip;
GN Name=rundc3a; Synonyms=rap2ip, rap2ip1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AB;
RA Zhang Y., Zhang J., Wang W., Zhu S.;
RT "A novel zebrafish homolog of Rap2ip is expressed both maternally and
RT zygotically during embryonic development.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically during
CC embryonic development.
CC -!- SIMILARITY: Belongs to the RUNDC3 family. {ECO:0000305}.
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DR EMBL; EF646262; ABU94270.1; -; mRNA.
DR EMBL; BC044502; AAH44502.1; -; mRNA.
DR EMBL; BC044540; AAH44540.1; -; mRNA.
DR EMBL; BC155785; AAI55786.1; -; mRNA.
DR RefSeq; NP_956443.1; NM_200149.1.
DR AlphaFoldDB; A7YDW0; -.
DR SMR; A7YDW0; -.
DR STRING; 7955.ENSDARP00000106658; -.
DR PaxDb; A7YDW0; -.
DR GeneID; 393118; -.
DR KEGG; dre:393118; -.
DR CTD; 393118; -.
DR ZFIN; ZDB-GENE-040426-842; rundc3ab.
DR eggNOG; KOG4381; Eukaryota.
DR InParanoid; A7YDW0; -.
DR OrthoDB; 714315at2759; -.
DR PhylomeDB; A7YDW0; -.
DR PRO; PR:A7YDW0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0010753; P:positive regulation of cGMP-mediated signaling; IBA:GO_Central.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; SSF140741; 1.
DR PROSITE; PS50826; RUN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..428
FT /note="RUN domain-containing protein 3A"
FT /id="PRO_0000324158"
FT DOMAIN 52..182
FT /note="RUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT REGION 349..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 237..314
FT /evidence="ECO:0000255"
FT COMPBIAS 357..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 12
FT /note="M -> L (in Ref. 2; AAH44502/AAH44540)"
FT /evidence="ECO:0000305"
FT CONFLICT 297
FT /note="R -> G (in Ref. 2; AAH44502/AAH44540)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 428 AA; 48476 MW; C7034112154EEE81 CRC64;
MEQSFMQSAM AMGAQSKKGF SRSIAVERKN LITVCRFSVK TLLEKYTAEP IDDSSEEFIN
FAAILEHILS HRFKGSGSWF DGQRSFWDFI RLACSKVPNN CISSIENMEN INSSRAKGRA
WLRVALMEKR LSEYIATALR DSRTTRRFYD EGAIMLREEA TVLTGMLIGL GAIDFSFCLK
GEALDGKSEA VIDYTPYLKF TQSYDYLSDD EDGQSVDSSN SDDSVEHPYI PLVTDEESWR
NKCRKMEQRF KIVNAQKGYL EELVRLRESQ LKNVEMENKK LTAGLEELQQ QSQKEKRELE
NIILELQEQL TSLIPGESHP LSKDLSIPLV NQWPSLQNYN NQEDSKLYHR GSFPSPEPHI
SLTTGSQRTE RKQNGKSWCT AEKDYTPSML GLCGSMSSLP SCKSLPSLRS TECLVNISAE
PSPALTPS
