ID   RUN3A_PONAB             Reviewed;         446 AA.
AC   Q5R565;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=RUN domain-containing protein 3A;
GN   Name=RUNDC3A;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as an effector of RAP2A in neuronal cells.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the GTP-bound form of RAP2A. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RUNDC3 family. {ECO:0000305}.
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DR   EMBL; CR861001; CAH93101.1; -; mRNA.
DR   RefSeq; NP_001126835.1; NM_001133363.1.
DR   AlphaFoldDB; Q5R565; -.
DR   SMR; Q5R565; -.
DR   STRING; 9601.ENSPPYP00000009369; -.
DR   Ensembl; ENSPPYT00000061392; ENSPPYP00000041166; ENSPPYG00000008334.
DR   GeneID; 100173842; -.
DR   KEGG; pon:100173842; -.
DR   CTD; 10900; -.
DR   eggNOG; KOG4381; Eukaryota.
DR   GeneTree; ENSGT00940000158922; -.
DR   InParanoid; Q5R565; -.
DR   OrthoDB; 714315at2759; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   Gene3D; 1.20.58.900; -; 1.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   Pfam; PF02759; RUN; 1.
DR   SMART; SM00593; RUN; 1.
DR   SUPFAM; SSF140741; SSF140741; 1.
DR   PROSITE; PS50826; RUN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..446
FT                   /note="RUN domain-containing protein 3A"
FT                   /id="PRO_0000324157"
FT   DOMAIN          52..189
FT                   /note="RUN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT   REGION          1..298
FT                   /note="Interaction with RAP2A"
FT                   /evidence="ECO:0000250"
FT   REGION          216..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          267..322
FT                   /evidence="ECO:0000255"
FT   MOD_RES         215
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         232
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         416
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
FT   MOD_RES         419
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O08576"
SQ   SEQUENCE   446 AA;  49777 MW;  9237F36C69E96B93 CRC64;
     METSFVQTTM ALGLSSKKAS SRNVAVERKN LITVCRFSVK TLLEKYTAEP IDDSSEEFVN
     FAAILEQILS HRFKACAPAG PVSWFSSDGQ RGFWDYIRLA CSKVPNNCVS SIENMENIST
     ARAKGRAWIR VALMEKRMSE YITTALRDTR TTRRFYDSGA IMLRDEATIL TGMLIGLSAI
     DFSFCLKGEV LDGKTPVVID YTPYLKFTQS YDYLTDEEER HSAESSTSED NSPEHPYLPL
     VTDEDSWYSK WHKMEQKFRI VYAQKGYLEE LVRLRESQLK DLEAENRRLQ LQLEEAAAQN
     QREKRELEGV ILELQEQLTG LIPSDHAPLA QGSKELTTPL VNQWPSLGTL NGAEGASNSK
     LYRRHSFMST EPLSAEASLS SDSQRLGEGT RDEEPWGPIG KDPTPSMLGL CGSLASIPSC
     KSLASFKSNE CLVSDSPEGS PALSPS