RUND1_MOUSE
ID RUND1_MOUSE Reviewed; 615 AA.
AC Q0VDN7; Q0VDN6; Q3U072; Q8C3C0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=RUN domain-containing protein 1;
GN Name=Rundc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Head, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role as p53/TP53 inhibitor and thus may have
CC oncogenic activity. {ECO:0000250}.
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DR EMBL; AK086362; BAC39654.1; -; mRNA.
DR EMBL; AK157156; BAE33983.1; -; mRNA.
DR EMBL; AL590996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119592; AAI19593.1; -; mRNA.
DR EMBL; BC119593; AAI19594.1; -; mRNA.
DR CCDS; CCDS25469.1; -.
DR RefSeq; NP_766154.2; NM_172566.4.
DR AlphaFoldDB; Q0VDN7; -.
DR SMR; Q0VDN7; -.
DR STRING; 10090.ENSMUSP00000042151; -.
DR iPTMnet; Q0VDN7; -.
DR PhosphoSitePlus; Q0VDN7; -.
DR EPD; Q0VDN7; -.
DR MaxQB; Q0VDN7; -.
DR PaxDb; Q0VDN7; -.
DR PRIDE; Q0VDN7; -.
DR ProteomicsDB; 260958; -.
DR Antibodypedia; 17190; 63 antibodies from 18 providers.
DR Ensembl; ENSMUST00000040561; ENSMUSP00000042151; ENSMUSG00000035007.
DR GeneID; 217201; -.
DR KEGG; mmu:217201; -.
DR UCSC; uc007lov.2; mouse.
DR CTD; 146923; -.
DR MGI; MGI:2144506; Rundc1.
DR VEuPathDB; HostDB:ENSMUSG00000035007; -.
DR eggNOG; KOG3759; Eukaryota.
DR GeneTree; ENSGT00390000007311; -.
DR HOGENOM; CLU_020366_0_0_1; -.
DR InParanoid; Q0VDN7; -.
DR OMA; WSYVART; -.
DR OrthoDB; 556116at2759; -.
DR PhylomeDB; Q0VDN7; -.
DR TreeFam; TF105949; -.
DR BioGRID-ORCS; 217201; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q0VDN7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q0VDN7; protein.
DR Bgee; ENSMUSG00000035007; Expressed in ear vesicle and 217 other tissues.
DR Genevisible; Q0VDN7; MM.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR Gene3D; 1.20.58.900; -; 1.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF140741; SSF140741; 1.
DR PROSITE; PS50826; RUN; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..615
FT /note="RUN domain-containing protein 1"
FT /id="PRO_0000284512"
FT DOMAIN 423..604
FT /note="RUN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00178"
FT REGION 15..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..102
FT /evidence="ECO:0000255"
FT COILED 163..238
FT /evidence="ECO:0000255"
FT COMPBIAS 154..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C34"
FT MOD_RES 499
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 144
FT /note="G -> R (in Ref. 1; BAE33983)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="K -> E (in Ref. 1; BAE33983 and 3; AAI19594)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="D -> G (in Ref. 1; BAC39654)"
FT /evidence="ECO:0000305"
FT CONFLICT 449
FT /note="S -> A (in Ref. 1; BAE33983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 615 AA; 67865 MW; 65DCB4F235CFFF37 CRC64;
MATVEVATEL GTVVTAVGPK AKDEEEEEEE EESLPPCETV RWAPVGAVAE AGPGAATFSE
AAAAEEPGAA PGSPSDATVR TLRRLEAERR QLDSALLALS SHFAQVQFRL RQVVRGAPAE
QQRLLRELED FAFRGCPHVL GYEGLADPCG GDESDVLPGD RPRVRGEDQS EQEKRERLET
QREKQKELIL QLKTQLDDLE TFAYQEGSYD SLPQSVVLER QRVIIDELIK KLDMNLNEDI
SSLSTEELRQ RVDAAVAQIV NPVRVKEQLV EQLKTQIRDL EMFISFIQDE VGSPLQTGGH
CECQASGKVG IGSTRVGGST LPPGPGKAKA EDAKRARETG LHLMRRALAV LQIFTVSQLG
CATGQIPQTL WQRSQADRDY SHLLKRLEVS VDRVKQLALR HQPHDHVITS ANLQDLSLGG
KDELTTVVRK ELTVAVRDLL AHGLYASSSG MSLVMAPLAC LLPVFSSAPE TMHPWELFVK
YYHAKNGRAY VESPARKLSQ SFALPIMGDT AVTPKQSLLT AIHLVLTEHD PFKRSADSEL
KALVCMALNE QRLVSWVNLI CKSGSLIEPH YQPWSYMAHT GFESALNLLS RLSSLKFSLP
VDLAVRQLKN IKDAF
