RUNT_DROME
ID RUNT_DROME Reviewed; 510 AA.
AC P22814; A0AVT9; O76551; Q6SD78; Q7KPD6; Q8MRF4; Q9TVG1; Q9TVZ7; Q9TZQ9;
AC Q9TZR0; Q9VRB6;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 2.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=Segmentation protein Runt;
GN Name=run; ORFNames=CG1849;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=2249771; DOI=10.1101/gad.4.10.1701;
RA Kania M.A., Bonner A.S., Duffy J.B., Gergen J.P.;
RT "The Drosophila segmentation gene runt encodes a novel nuclear regulatory
RT protein that is also expressed in the developing nervous system.";
RL Genes Dev. 4:1701-1713(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=OK13, OK17, OK5, OK94, Z11, Z16, Z27, Z42, Z55, Z64, and Z74;
RX PubMed=10368951; DOI=10.1093/oxfordjournals.molbev.a026157;
RA Labate J.A., Biermann C.H., Eanes W.F.;
RT "Nucleotide variation at the runt locus in Drosophila melanogaster and
RT Drosophila simulans.";
RL Mol. Biol. Evol. 16:724-731(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kapadia B., Kronmiller B., Li P.W., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-275.
RC STRAIN=Ara1, Ara10, Ara11, Ara12, Ara13, Ara15, Ara2, Ara3, Ara4, Ara5,
RC Ara6, Ara7, Ara8, Ara9, Cog1, Cog11, Cog12, Cog13, Cog14, Cog15, Cog2,
RC Cog3, Cog4, Cog5, Cog6, Cog7, Cog8, Cog9, Gh51, Gh52, Gh53, Gh54, Gh55,
RC Gh56, Gh57, Gh58, Gh59, Gh60, Gh61, Gh62, Gh63, Gh65, KN1, KN10, KN11,
RC KN12, KN13, KN15, KN2, KN3, KN4, KN5, KN6, KN7, KN8, KN9, Mad1, Mad10,
RC Mad11, Mad13, Mad14, Mad17, Mad2, Mad3, Mad4, Mad5, Mad6, Mad7, Mad8, Mad9,
RC Mif1, Mif10, Mif11, Mif12, Mif13, Mif15, Mif16, Mif2, Mif3, Mif4, Mif6,
RC Mif7, Mif8, Mif9, Nd1, Nd10, Nd11, Nd12, Nd13, Nd14, Nd2, Nd3, Nd4, Nd5,
RC Nd6, Nd7, Nd8, Nd9, Nia1, Nia10, Nia11, Nia13, Nia16, Nia17, Nia18, Nia2,
RC Nia20, Nia21, Nia22, Nia3, Nia6, Nia9, Pe1, Pe12, Pe13, Pe14, Pe15, Pe16,
RC Pe17, Pe18, Pe19, Pe2, Pe4, Pe7, Pe8, Pe9, USA1, USA10, USA11, USA12,
RC USA13, USA14, USA2, USA3, USA4, USA5, USA6, USA7, USA8, USA9, Z12, Z121,
RC Z145, Z147, Z18, Z27, Z30, Z32, Z33, Z422, Z53, Z67, and Z75;
RX PubMed=15014160; DOI=10.1093/molbev/msh089;
RA Baudry E., Viginier B., Veuille M.;
RT "Non-African populations of Drosophila melanogaster have a unique origin.";
RL Mol. Biol. Evol. 21:1482-1491(2004).
RN [7]
RP SIMILARITY TO AML1.
RX PubMed=1560822; DOI=10.1038/356484b0;
RA Daga A., Tighe J.E., Calabi F.;
RT "Leukaemia/Drosophila homology.";
RL Nature 356:484-484(1992).
CC -!- FUNCTION: Plays a pivotal role in regulating the expression of other
CC pair-rule genes such as eve, ftz, and h. {ECO:0000269|PubMed:2249771}.
CC -!- INTERACTION:
CC P22814; Q24039: Bro; NbExp=6; IntAct=EBI-868309, EBI-148540;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399,
CC ECO:0000269|PubMed:2249771}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic central and peripheral
CC nervous system. {ECO:0000269|PubMed:2249771}.
CC -!- DEVELOPMENTAL STAGE: Most abundantly expressed at the blastoderm stage
CC of embryogenesis. {ECO:0000269|PubMed:2249771}.
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DR EMBL; X56432; CAA39817.1; -; mRNA.
DR EMBL; AF077070; AAC27776.1; -; Genomic_DNA.
DR EMBL; AF077071; AAC27777.1; -; Genomic_DNA.
DR EMBL; AF077072; AAC27778.1; -; Genomic_DNA.
DR EMBL; AF077073; AAC27779.1; -; Genomic_DNA.
DR EMBL; AF077074; AAC27780.1; -; Genomic_DNA.
DR EMBL; AF077075; AAC27781.1; -; Genomic_DNA.
DR EMBL; AF077076; AAC27782.1; -; Genomic_DNA.
DR EMBL; AF077077; AAC27783.1; -; Genomic_DNA.
DR EMBL; AF077078; AAC27784.1; -; Genomic_DNA.
DR EMBL; AF077079; AAC27785.1; -; Genomic_DNA.
DR EMBL; AF077080; AAC27786.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF50886.1; -; Genomic_DNA.
DR EMBL; AY121615; AAM51942.2; -; mRNA.
DR EMBL; BT029257; ABK30894.1; -; mRNA.
DR EMBL; AY459923; AAS16109.1; -; Genomic_DNA.
DR EMBL; AY459924; AAS16110.1; -; Genomic_DNA.
DR EMBL; AY459925; AAS16111.1; -; Genomic_DNA.
DR EMBL; AY459926; AAS16112.1; -; Genomic_DNA.
DR EMBL; AY459927; AAS16113.1; -; Genomic_DNA.
DR EMBL; AY459928; AAS16114.1; -; Genomic_DNA.
DR EMBL; AY459929; AAS16115.1; -; Genomic_DNA.
DR EMBL; AY459930; AAS16116.1; -; Genomic_DNA.
DR EMBL; AY459931; AAS16117.1; -; Genomic_DNA.
DR EMBL; AY459932; AAS16118.1; -; Genomic_DNA.
DR EMBL; AY459933; AAS16119.1; -; Genomic_DNA.
DR EMBL; AY459934; AAS16120.1; -; Genomic_DNA.
DR EMBL; AY459935; AAS16121.1; -; Genomic_DNA.
DR EMBL; AY459936; AAS16122.1; -; Genomic_DNA.
DR EMBL; AY459937; AAS16123.1; -; Genomic_DNA.
DR EMBL; AY459938; AAS16124.1; -; Genomic_DNA.
DR EMBL; AY459939; AAS16125.1; -; Genomic_DNA.
DR EMBL; AY459940; AAS16126.1; -; Genomic_DNA.
DR EMBL; AY459941; AAS16127.1; -; Genomic_DNA.
DR EMBL; AY459942; AAS16128.1; -; Genomic_DNA.
DR EMBL; AY459943; AAS16129.1; -; Genomic_DNA.
DR EMBL; AY459944; AAS16130.1; -; Genomic_DNA.
DR EMBL; AY459945; AAS16131.1; -; Genomic_DNA.
DR EMBL; AY459946; AAS16132.1; -; Genomic_DNA.
DR EMBL; AY459947; AAS16133.1; -; Genomic_DNA.
DR EMBL; AY459948; AAS16134.1; -; Genomic_DNA.
DR EMBL; AY459949; AAS16135.1; -; Genomic_DNA.
DR EMBL; AY459950; AAS16136.1; -; Genomic_DNA.
DR EMBL; AY459951; AAS16137.1; -; Genomic_DNA.
DR EMBL; AY459952; AAS16138.1; -; Genomic_DNA.
DR EMBL; AY459953; AAS16139.1; -; Genomic_DNA.
DR EMBL; AY459954; AAS16140.1; -; Genomic_DNA.
DR EMBL; AY459955; AAS16141.1; -; Genomic_DNA.
DR EMBL; AY459956; AAS16142.1; -; Genomic_DNA.
DR EMBL; AY459957; AAS16143.1; -; Genomic_DNA.
DR EMBL; AY459958; AAS16144.1; -; Genomic_DNA.
DR EMBL; AY459959; AAS16145.1; -; Genomic_DNA.
DR EMBL; AY459960; AAS16146.1; -; Genomic_DNA.
DR EMBL; AY459961; AAS16147.1; -; Genomic_DNA.
DR EMBL; AY459962; AAS16148.1; -; Genomic_DNA.
DR EMBL; AY459963; AAS16149.1; -; Genomic_DNA.
DR EMBL; AY459964; AAS16150.1; -; Genomic_DNA.
DR EMBL; AY459965; AAS16151.1; -; Genomic_DNA.
DR EMBL; AY459966; AAS16152.1; -; Genomic_DNA.
DR EMBL; AY459967; AAS16153.1; -; Genomic_DNA.
DR EMBL; AY459968; AAS16154.1; -; Genomic_DNA.
DR EMBL; AY459969; AAS16155.1; -; Genomic_DNA.
DR EMBL; AY459970; AAS16156.1; -; Genomic_DNA.
DR EMBL; AY459971; AAS16157.1; -; Genomic_DNA.
DR EMBL; AY459972; AAS16158.1; -; Genomic_DNA.
DR EMBL; AY459973; AAS16159.1; -; Genomic_DNA.
DR EMBL; AY459974; AAS16160.1; -; Genomic_DNA.
DR EMBL; AY459975; AAS16161.1; -; Genomic_DNA.
DR EMBL; AY459976; AAS16162.1; -; Genomic_DNA.
DR EMBL; AY459977; AAS16163.1; -; Genomic_DNA.
DR EMBL; AY459978; AAS16164.1; -; Genomic_DNA.
DR EMBL; AY459979; AAS16165.1; -; Genomic_DNA.
DR EMBL; AY459980; AAS16166.1; -; Genomic_DNA.
DR EMBL; AY459981; AAS16167.1; -; Genomic_DNA.
DR EMBL; AY459982; AAS16168.1; -; Genomic_DNA.
DR EMBL; AY459983; AAS16169.1; -; Genomic_DNA.
DR EMBL; AY459984; AAS16170.1; -; Genomic_DNA.
DR EMBL; AY459985; AAS16171.1; -; Genomic_DNA.
DR EMBL; AY459986; AAS16172.1; -; Genomic_DNA.
DR EMBL; AY459987; AAS16173.1; -; Genomic_DNA.
DR EMBL; AY459988; AAS16174.1; -; Genomic_DNA.
DR EMBL; AY459989; AAS16175.1; -; Genomic_DNA.
DR EMBL; AY459990; AAS16176.1; -; Genomic_DNA.
DR EMBL; AY459991; AAS16177.1; -; Genomic_DNA.
DR EMBL; AY459992; AAS16178.1; -; Genomic_DNA.
DR EMBL; AY459993; AAS16179.1; -; Genomic_DNA.
DR EMBL; AY459994; AAS16180.1; -; Genomic_DNA.
DR EMBL; AY459995; AAS16181.1; -; Genomic_DNA.
DR EMBL; AY459996; AAS16182.1; -; Genomic_DNA.
DR EMBL; AY459997; AAS16183.1; -; Genomic_DNA.
DR EMBL; AY459998; AAS16184.1; -; Genomic_DNA.
DR EMBL; AY459999; AAS16185.1; -; Genomic_DNA.
DR EMBL; AY460000; AAS16186.1; -; Genomic_DNA.
DR EMBL; AY460001; AAS16187.1; -; Genomic_DNA.
DR EMBL; AY460002; AAS16188.1; -; Genomic_DNA.
DR EMBL; AY460003; AAS16189.1; -; Genomic_DNA.
DR EMBL; AY460004; AAS16190.1; -; Genomic_DNA.
DR EMBL; AY460005; AAS16191.1; -; Genomic_DNA.
DR EMBL; AY460006; AAS16192.1; -; Genomic_DNA.
DR EMBL; AY460007; AAS16193.1; -; Genomic_DNA.
DR EMBL; AY460008; AAS16194.1; -; Genomic_DNA.
DR EMBL; AY460009; AAS16195.1; -; Genomic_DNA.
DR EMBL; AY460010; AAS16196.1; -; Genomic_DNA.
DR EMBL; AY460011; AAS16197.1; -; Genomic_DNA.
DR EMBL; AY460012; AAS16198.1; -; Genomic_DNA.
DR EMBL; AY460013; AAS16199.1; -; Genomic_DNA.
DR EMBL; AY460014; AAS16200.1; -; Genomic_DNA.
DR EMBL; AY460015; AAS16201.1; -; Genomic_DNA.
DR EMBL; AY460016; AAS16202.1; -; Genomic_DNA.
DR EMBL; AY460017; AAS16203.1; -; Genomic_DNA.
DR EMBL; AY460018; AAS16204.1; -; Genomic_DNA.
DR EMBL; AY460019; AAS16205.1; -; Genomic_DNA.
DR EMBL; AY460020; AAS16206.1; -; Genomic_DNA.
DR EMBL; AY460021; AAS16207.1; -; Genomic_DNA.
DR EMBL; AY460022; AAS16208.1; -; Genomic_DNA.
DR EMBL; AY460023; AAS16209.1; -; Genomic_DNA.
DR EMBL; AY460024; AAS16210.1; -; Genomic_DNA.
DR EMBL; AY460025; AAS16211.1; -; Genomic_DNA.
DR EMBL; AY460026; AAS16212.1; -; Genomic_DNA.
DR EMBL; AY460027; AAS16213.1; -; Genomic_DNA.
DR EMBL; AY460028; AAS16214.1; -; Genomic_DNA.
DR EMBL; AY460029; AAS16215.1; -; Genomic_DNA.
DR EMBL; AY460030; AAS16216.1; -; Genomic_DNA.
DR EMBL; AY460031; AAS16217.1; -; Genomic_DNA.
DR EMBL; AY460032; AAS16218.1; -; Genomic_DNA.
DR EMBL; AY460033; AAS16219.1; -; Genomic_DNA.
DR EMBL; AY460034; AAS16220.1; -; Genomic_DNA.
DR EMBL; AY460035; AAS16221.1; -; Genomic_DNA.
DR EMBL; AY460036; AAS16222.1; -; Genomic_DNA.
DR EMBL; AY460037; AAS16223.1; -; Genomic_DNA.
DR EMBL; AY460038; AAS16224.1; -; Genomic_DNA.
DR EMBL; AY460039; AAS16225.1; -; Genomic_DNA.
DR EMBL; AY460040; AAS16226.1; -; Genomic_DNA.
DR EMBL; AY460041; AAS16227.1; -; Genomic_DNA.
DR EMBL; AY460042; AAS16228.1; -; Genomic_DNA.
DR EMBL; AY460043; AAS16229.1; -; Genomic_DNA.
DR EMBL; AY460044; AAS16230.1; -; Genomic_DNA.
DR EMBL; AY460045; AAS16231.1; -; Genomic_DNA.
DR EMBL; AY460046; AAS16232.1; -; Genomic_DNA.
DR EMBL; AY460047; AAS16233.1; -; Genomic_DNA.
DR EMBL; AY460048; AAS16234.1; -; Genomic_DNA.
DR EMBL; AY460049; AAS16235.1; -; Genomic_DNA.
DR EMBL; AY460050; AAS16236.1; -; Genomic_DNA.
DR EMBL; AY460051; AAS16237.1; -; Genomic_DNA.
DR EMBL; AY460052; AAS16238.1; -; Genomic_DNA.
DR EMBL; AY460053; AAS16239.1; -; Genomic_DNA.
DR EMBL; AY460054; AAS16240.1; -; Genomic_DNA.
DR EMBL; AY460055; AAS16241.1; -; Genomic_DNA.
DR EMBL; AY460056; AAS16242.1; -; Genomic_DNA.
DR EMBL; AY460057; AAS16243.1; -; Genomic_DNA.
DR EMBL; AY460058; AAS16244.1; -; Genomic_DNA.
DR EMBL; AY460059; AAS16245.1; -; Genomic_DNA.
DR EMBL; AY460060; AAS16246.1; -; Genomic_DNA.
DR EMBL; AY460061; AAS16247.1; -; Genomic_DNA.
DR EMBL; AY460062; AAS16248.1; -; Genomic_DNA.
DR EMBL; AY460063; AAS16249.1; -; Genomic_DNA.
DR EMBL; AY460064; AAS16250.1; -; Genomic_DNA.
DR EMBL; AY460065; AAS16251.1; -; Genomic_DNA.
DR EMBL; AY460066; AAS16252.1; -; Genomic_DNA.
DR EMBL; AY460067; AAS16253.1; -; Genomic_DNA.
DR EMBL; AY460068; AAS16254.1; -; Genomic_DNA.
DR EMBL; AY460069; AAS16255.1; -; Genomic_DNA.
DR EMBL; AY460070; AAS16256.1; -; Genomic_DNA.
DR EMBL; AY460071; AAS16257.1; -; Genomic_DNA.
DR EMBL; AY460072; AAS16258.1; -; Genomic_DNA.
DR EMBL; AY460073; AAS16259.1; -; Genomic_DNA.
DR EMBL; AY460074; AAS16260.1; -; Genomic_DNA.
DR EMBL; AY460075; AAS16261.1; -; Genomic_DNA.
DR PIR; A36392; A36392.
DR RefSeq; NP_001285501.1; NM_001298572.1.
DR RefSeq; NP_523424.2; NM_078700.4.
DR AlphaFoldDB; P22814; -.
DR SMR; P22814; -.
DR BioGRID; 59347; 22.
DR ELM; P22814; -.
DR IntAct; P22814; 7.
DR STRING; 7227.FBpp0076971; -.
DR PaxDb; P22814; -.
DR DNASU; 33059; -.
DR EnsemblMetazoa; FBtr0077279; FBpp0076971; FBgn0003300.
DR EnsemblMetazoa; FBtr0345922; FBpp0311837; FBgn0003300.
DR GeneID; 33059; -.
DR KEGG; dme:Dmel_CG1849; -.
DR CTD; 33059; -.
DR FlyBase; FBgn0003300; run.
DR VEuPathDB; VectorBase:FBgn0003300; -.
DR eggNOG; KOG3982; Eukaryota.
DR HOGENOM; CLU_041058_1_0_1; -.
DR InParanoid; P22814; -.
DR OMA; KQSYGYP; -.
DR OrthoDB; 1130963at2759; -.
DR PhylomeDB; P22814; -.
DR Reactome; R-DME-549127; Organic cation transport.
DR Reactome; R-DME-8878166; Transcriptional regulation by RUNX2.
DR Reactome; R-DME-8931987; RUNX1 regulates estrogen receptor mediated transcription.
DR Reactome; R-DME-8934593; Regulation of RUNX1 Expression and Activity.
DR Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-DME-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Reactome; R-DME-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Reactome; R-DME-8939246; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.
DR Reactome; R-DME-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
DR Reactome; R-DME-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-DME-8940973; RUNX2 regulates osteoblast differentiation.
DR Reactome; R-DME-8941326; RUNX2 regulates bone development.
DR Reactome; R-DME-8941855; RUNX3 regulates CDKN1A transcription.
DR Reactome; R-DME-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-DME-8951430; RUNX3 regulates WNT signaling.
DR Reactome; R-DME-8951671; RUNX3 regulates YAP1-mediated transcription.
DR Reactome; R-DME-8951936; RUNX3 regulates p14-ARF.
DR Reactome; R-DME-9018519; Estrogen-dependent gene expression.
DR SignaLink; P22814; -.
DR BioGRID-ORCS; 33059; 0 hits in 3 CRISPR screens.
DR ChiTaRS; run; fly.
DR GenomeRNAi; 33059; -.
DR PRO; PR:P22814; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0003300; Expressed in anlage and 50 other tissues.
DR ExpressionAtlas; P22814; baseline and differential.
DR Genevisible; P22814; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0048592; P:eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007377; P:germ-band extension; IMP:FlyBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0007400; P:neuroblast fate determination; TAS:FlyBase.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; TAS:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:FlyBase.
DR GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR GO; GO:0007540; P:sex determination, establishment of X:A ratio; TAS:FlyBase.
DR GO; GO:0007419; P:ventral cord development; TAS:FlyBase.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR000040; AML1_Runt.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR013524; Runt_dom.
DR PANTHER; PTHR11950; PTHR11950; 1.
DR Pfam; PF00853; Runt; 1.
DR PRINTS; PR00967; ONCOGENEAML1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51062; RUNT; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Nucleus; Pair-rule protein; Reference proteome;
KW Segmentation polarity protein; Transcription; Transcription regulation.
FT CHAIN 1..510
FT /note="Segmentation protein Runt"
FT /id="PRO_0000174664"
FT DOMAIN 106..234
FT /note="Runt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00399"
FT REGION 58..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 32
FT /note="A -> P"
FT VARIANT 44
FT /note="T -> A (in strain: OK17, OK94, Z42, Z55, Z64 and
FT Z74)"
FT VARIANT 315
FT /note="P -> S (in strain: OK94)"
FT VARIANT 469
FT /note="A -> S (in strain: Z27, OK13, OK5 and Z16)"
FT CONFLICT 18
FT /note="Missing (in Ref. 1; CAA39817)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="V -> W (in Ref. 1; CAA39817)"
FT /evidence="ECO:0000305"
FT CONFLICT 231..236
FT /note="EPRSKQ -> DPR (in Ref. 5; AAM51942)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="A -> S (in Ref. 1; CAA39817 and 2; AAC27776/
FT AAC27777/AAC27778/AAC27779/AAC27780/AAC27781/AAC27782/
FT AAC27783/AAC27784/AAC27785/AAC27786)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 510 AA; 53209 MW; C32B1D344433362E CRC64;
MHLPAGPTMV ANNTQVLAAA AAAAAAAAAA VAQGPGPQQS SNATTASAIA INPAQSLANT
STHSASSTGS STPDLSTNNT SSSSNATTSP QNSAKMPSSM TDMFASLHEM LQEYHGELAQ
TGSPSILCSA LPNHWRSNKS LPGAFKVIAL DDVPDGTLVS IKCGNDENYC GELRNCTTTM
KNQVAKFNDL RFVGRSGRGK SFTLTITIAT YPVQIASYSK AIKVTVDGPR EPRSKQSYGY
PHPGAFNPFM LNPAWLDAAY MTYGYADYFR HQAAAQAAQV HHPALAKSSA SSVSPNPNPS
VATSSSSAVQ PSEYPHPAAA VAAAAGQPAA MMPSPPGAAP ATPYAIPQFP FNHVAAAAAA
KAATPHAFHP YNFAAAAGLR ARNAALHHQS EPVHVSPASS RPSSSSPTQQ HVLLKLNTSI
ETSSIHEQSA SDGDSDDEQI DVVKSEFDLD KSLDVAPLRM RCDLKAPSAM KPLYHESGPG
AVANSRQPSP ETTTKIKSAA VQQKTVWRPY
