ID   RUNT_MANSE              Reviewed;          79 AA.
AC   Q25520;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Segmentation protein Runt;
DE   Flags: Fragment;
GN   Name=RUNT;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=8022829; DOI=10.1073/pnas.91.14.6634;
RA   Kraft R., Jaeckle H.;
RT   "Drosophila mode of metamerization in the embryogenesis of the lepidopteran
RT   insect Manduca sexta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6634-6638(1994).
CC   -!- FUNCTION: Plays a pivotal role in regulating the expression of other
CC       pair-rule genes such as eve, ftz, and h. Plays a role in the
CC       developmental pathways of sex determination and neurogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer runt and brother (or big brother) proteins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00399}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in a series of equally spaced stripes
CC       covering the trunk anlagen in the blastoderm embryo. By late
CC       blastoderm, expressed in the head lobes.
CC   -!- DOMAIN: The runt domain is responsible for the DNA-binding properties
CC       of the alpha subunit and also mediates interaction with subunit beta.
CC       The transactivation domain is located downstream of the runt domain.
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DR   EMBL; Z30279; CAA82953.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q25520; -.
DR   SMR; Q25520; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007366; P:periodic partitioning by pair rule gene; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   Gene3D; 2.60.40.720; -; 1.
DR   InterPro; IPR000040; AML1_Runt.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR   InterPro; IPR013524; Runt_dom.
DR   PANTHER; PTHR11950; PTHR11950; 1.
DR   Pfam; PF00853; Runt; 1.
DR   PRINTS; PR00967; ONCOGENEAML1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   PROSITE; PS51062; RUNT; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Pair-rule protein;
KW   Segmentation polarity protein; Transcription; Transcription regulation.
FT   CHAIN           <1..>79
FT                   /note="Segmentation protein Runt"
FT                   /id="PRO_0000174665"
FT   DOMAIN          <1..>79
FT                   /note="Runt"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00399"
FT   NON_TER         1
FT   NON_TER         79
SQ   SEQUENCE   79 AA;  8569 MW;  91CA44BBFB791E45 CRC64;
     ALDDVQDGTL VTIKAGNDEN VMAELRNCTA VMKNQVAKFN DLRFVGRSGR GKSFTLTITI
     STFPSQVATY SKAIKVTVD