RUSD1_MOUSE
ID RUSD1_MOUSE Reviewed; 306 AA.
AC Q8VCZ8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=RNA pseudouridylate synthase domain-containing protein 1;
DE AltName: Full=Ribosomal large subunit pseudouridine synthase C-like protein;
GN Name=Rpusd1; Synonyms=Rlucl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK049334; BAC33690.1; -; mRNA.
DR EMBL; BC018186; AAH18186.1; -; mRNA.
DR CCDS; CCDS28524.1; -.
DR RefSeq; NP_082285.1; NM_028009.3.
DR RefSeq; XP_006523477.1; XM_006523414.1.
DR AlphaFoldDB; Q8VCZ8; -.
DR SMR; Q8VCZ8; -.
DR STRING; 10090.ENSMUSP00000043825; -.
DR iPTMnet; Q8VCZ8; -.
DR PhosphoSitePlus; Q8VCZ8; -.
DR EPD; Q8VCZ8; -.
DR MaxQB; Q8VCZ8; -.
DR PaxDb; Q8VCZ8; -.
DR PRIDE; Q8VCZ8; -.
DR ProteomicsDB; 262730; -.
DR Antibodypedia; 22914; 72 antibodies from 14 providers.
DR DNASU; 106707; -.
DR Ensembl; ENSMUST00000047273; ENSMUSP00000043825; ENSMUSG00000041199.
DR Ensembl; ENSMUST00000237785; ENSMUSP00000158547; ENSMUSG00000041199.
DR GeneID; 106707; -.
DR KEGG; mmu:106707; -.
DR UCSC; uc008bbl.1; mouse.
DR CTD; 113000; -.
DR MGI; MGI:1919186; Rpusd1.
DR VEuPathDB; HostDB:ENSMUSG00000041199; -.
DR eggNOG; KOG1919; Eukaryota.
DR GeneTree; ENSGT00510000048339; -.
DR HOGENOM; CLU_016902_10_0_1; -.
DR InParanoid; Q8VCZ8; -.
DR OMA; HVSQSRM; -.
DR OrthoDB; 821308at2759; -.
DR PhylomeDB; Q8VCZ8; -.
DR TreeFam; TF324755; -.
DR BioGRID-ORCS; 106707; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q8VCZ8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8VCZ8; protein.
DR Bgee; ENSMUSG00000041199; Expressed in primary visual cortex and 164 other tissues.
DR ExpressionAtlas; Q8VCZ8; baseline and differential.
DR Genevisible; Q8VCZ8; MM.
DR GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Reference proteome.
FT CHAIN 1..306
FT /note="RNA pseudouridylate synthase domain-containing
FT protein 1"
FT /id="PRO_0000300817"
FT REGION 255..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 67
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UJJ7"
SQ SEQUENCE 306 AA; 34231 MW; 07CF4BD530D3E681 CRC64;
MEPGSMENLS IVYQSSDFLV VNKHWDLRID SKTWRETLTL QKQLRHHFPE LADPDTCYGF
RFCHQLDFST SGALCVALNK AAAGSAYKCF KERRVTKAYL ALVRGHVQES QVTINYAIGR
NSTEGRTHTM CIEGTHGCEN PKPSLTELLV LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC
SALGHPIVGD LTYGQAEDQE DQPFRMMLHA FYLRIPTQAE RVEACTPDPF LPALDACWSP
STCVQPLEQL IQALRTDPDP DPMSGGPRPC SPSTPQPRPG RPPPETEAQR ASCLQWLSEW
TLEPDN
