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RUSF1_HUMAN
ID   RUSF1_HUMAN             Reviewed;         468 AA.
AC   Q96GQ5; Q53GL8; Q8NAJ4; Q9BVY3; Q9H887;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=RUS family member 1 {ECO:0000305};
GN   Name=RUSF1 {ECO:0000312|HGNC:HGNC:25848}; Synonyms=C16orf58;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Prostate, and Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Kidney;
RA   Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA   Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-185.
RC   TISSUE=Placenta, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [7]
RP   VARIANT [LARGE SCALE ANALYSIS] GLU-43.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- INTERACTION:
CC       Q96GQ5; Q13520: AQP6; NbExp=3; IntAct=EBI-8636004, EBI-13059134;
CC       Q96GQ5; Q8N6S5: ARL6IP6; NbExp=3; IntAct=EBI-8636004, EBI-2808844;
CC       Q96GQ5; P23560-2: BDNF; NbExp=3; IntAct=EBI-8636004, EBI-12275524;
CC       Q96GQ5; Q13323: BIK; NbExp=3; IntAct=EBI-8636004, EBI-700794;
CC       Q96GQ5; Q6UWT4: C5orf46; NbExp=3; IntAct=EBI-8636004, EBI-11986083;
CC       Q96GQ5; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8636004, EBI-1045797;
CC       Q96GQ5; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-8636004, EBI-11522780;
CC       Q96GQ5; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-8636004, EBI-6942903;
CC       Q96GQ5; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-8636004, EBI-852194;
CC       Q96GQ5; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-8636004, EBI-12831978;
CC       Q96GQ5; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-8636004, EBI-3923585;
CC       Q96GQ5; Q15125: EBP; NbExp=3; IntAct=EBI-8636004, EBI-3915253;
CC       Q96GQ5; Q08426: EHHADH; NbExp=3; IntAct=EBI-8636004, EBI-2339219;
CC       Q96GQ5; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-8636004, EBI-781551;
CC       Q96GQ5; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8636004, EBI-18304435;
CC       Q96GQ5; O15552: FFAR2; NbExp=3; IntAct=EBI-8636004, EBI-2833872;
CC       Q96GQ5; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-8636004, EBI-3918971;
CC       Q96GQ5; P48165: GJA8; NbExp=3; IntAct=EBI-8636004, EBI-17458373;
CC       Q96GQ5; O15529: GPR42; NbExp=3; IntAct=EBI-8636004, EBI-18076404;
CC       Q96GQ5; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-8636004, EBI-18053395;
CC       Q96GQ5; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-8636004, EBI-3918847;
CC       Q96GQ5; O43464: HTRA2; NbExp=3; IntAct=EBI-8636004, EBI-517086;
CC       Q96GQ5; P42858: HTT; NbExp=3; IntAct=EBI-8636004, EBI-466029;
CC       Q96GQ5; P15260: IFNGR1; NbExp=4; IntAct=EBI-8636004, EBI-1030755;
CC       Q96GQ5; Q13651: IL10RA; NbExp=3; IntAct=EBI-8636004, EBI-1031656;
CC       Q96GQ5; P11215: ITGAM; NbExp=3; IntAct=EBI-8636004, EBI-2568251;
CC       Q96GQ5; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8636004, EBI-2820517;
CC       Q96GQ5; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-8636004, EBI-6163737;
CC       Q96GQ5; Q96JQ5: MS4A4A; NbExp=3; IntAct=EBI-8636004, EBI-12820341;
CC       Q96GQ5; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-8636004, EBI-12382569;
CC       Q96GQ5; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-8636004, EBI-16427978;
CC       Q96GQ5; O15173: PGRMC2; NbExp=3; IntAct=EBI-8636004, EBI-1050125;
CC       Q96GQ5; P41219: PRPH; NbExp=3; IntAct=EBI-8636004, EBI-752074;
CC       Q96GQ5; P15151: PVR; NbExp=3; IntAct=EBI-8636004, EBI-3919694;
CC       Q96GQ5; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-8636004, EBI-10192441;
CC       Q96GQ5; Q99942: RNF5; NbExp=3; IntAct=EBI-8636004, EBI-348482;
CC       Q96GQ5; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-8636004, EBI-17247926;
CC       Q96GQ5; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-8636004, EBI-14193895;
CC       Q96GQ5; Q14973: SLC10A1; NbExp=3; IntAct=EBI-8636004, EBI-3923031;
CC       Q96GQ5; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-8636004, EBI-18159983;
CC       Q96GQ5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-8636004, EBI-10262251;
CC       Q96GQ5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-8636004, EBI-17295964;
CC       Q96GQ5; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-8636004, EBI-13389236;
CC       Q96GQ5; Q9NPE6: SPAG4; NbExp=3; IntAct=EBI-8636004, EBI-10819434;
CC       Q96GQ5; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-8636004, EBI-17280858;
CC       Q96GQ5; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-8636004, EBI-19027521;
CC       Q96GQ5; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-8636004, EBI-10982110;
CC       Q96GQ5; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-8636004, EBI-10314986;
CC       Q96GQ5; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-8636004, EBI-11722971;
CC       Q96GQ5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-8636004, EBI-6447886;
CC       Q96GQ5; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-8636004, EBI-10180829;
CC       Q96GQ5; O76024: WFS1; NbExp=3; IntAct=EBI-8636004, EBI-720609;
CC       Q96GQ5; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-8636004, EBI-748373;
CC       Q96GQ5; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-8636004, EBI-12837904;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96GQ5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96GQ5-2; Sequence=VSP_024255, VSP_024256;
CC   -!- SIMILARITY: Belongs to the RUS1 family. {ECO:0000305}.
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DR   EMBL; AK023930; BAB14730.1; -; mRNA.
DR   EMBL; AK092580; BAC03918.1; -; mRNA.
DR   EMBL; AK222913; BAD96633.1; -; mRNA.
DR   EMBL; BC000822; AAH00822.1; -; mRNA.
DR   EMBL; BC009308; AAH09308.1; -; mRNA.
DR   CCDS; CCDS10715.1; -. [Q96GQ5-1]
DR   RefSeq; NP_073581.2; NM_022744.3. [Q96GQ5-1]
DR   AlphaFoldDB; Q96GQ5; -.
DR   BioGRID; 122269; 233.
DR   IntAct; Q96GQ5; 86.
DR   MINT; Q96GQ5; -.
DR   STRING; 9606.ENSP00000317579; -.
DR   iPTMnet; Q96GQ5; -.
DR   PhosphoSitePlus; Q96GQ5; -.
DR   SwissPalm; Q96GQ5; -.
DR   BioMuta; C16orf58; -.
DR   DMDM; 143955305; -.
DR   EPD; Q96GQ5; -.
DR   jPOST; Q96GQ5; -.
DR   MassIVE; Q96GQ5; -.
DR   MaxQB; Q96GQ5; -.
DR   PaxDb; Q96GQ5; -.
DR   PeptideAtlas; Q96GQ5; -.
DR   PRIDE; Q96GQ5; -.
DR   ProteomicsDB; 76653; -. [Q96GQ5-1]
DR   ProteomicsDB; 76654; -. [Q96GQ5-2]
DR   Antibodypedia; 14220; 32 antibodies from 15 providers.
DR   DNASU; 64755; -.
DR   Ensembl; ENST00000327237.7; ENSP00000317579.2; ENSG00000140688.17. [Q96GQ5-1]
DR   Ensembl; ENST00000430477.6; ENSP00000398074.3; ENSG00000140688.17. [Q96GQ5-1]
DR   GeneID; 64755; -.
DR   KEGG; hsa:64755; -.
DR   MANE-Select; ENST00000327237.7; ENSP00000317579.2; NM_022744.4; NP_073581.2.
DR   UCSC; uc002eci.4; human. [Q96GQ5-1]
DR   CTD; 64755; -.
DR   DisGeNET; 64755; -.
DR   GeneCards; RUSF1; -.
DR   HGNC; HGNC:25848; RUSF1.
DR   HPA; ENSG00000140688; Low tissue specificity.
DR   neXtProt; NX_Q96GQ5; -.
DR   OpenTargets; ENSG00000140688; -.
DR   VEuPathDB; HostDB:ENSG00000140688; -.
DR   eggNOG; KOG4249; Eukaryota.
DR   GeneTree; ENSGT00390000000050; -.
DR   InParanoid; Q96GQ5; -.
DR   OMA; PFQIWDS; -.
DR   PhylomeDB; Q96GQ5; -.
DR   TreeFam; TF326424; -.
DR   PathwayCommons; Q96GQ5; -.
DR   SignaLink; Q96GQ5; -.
DR   BioGRID-ORCS; 64755; 12 hits in 1071 CRISPR screens.
DR   ChiTaRS; C16orf58; human.
DR   GeneWiki; C16orf58; -.
DR   GenomeRNAi; 64755; -.
DR   Pharos; Q96GQ5; Tdark.
DR   PRO; PR:Q96GQ5; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q96GQ5; protein.
DR   Bgee; ENSG00000140688; Expressed in adenohypophysis and 180 other tissues.
DR   ExpressionAtlas; Q96GQ5; baseline and differential.
DR   Genevisible; Q96GQ5; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   InterPro; IPR006968; RUS_fam.
DR   PANTHER; PTHR12770; PTHR12770; 1.
DR   Pfam; PF04884; UVB_sens_prot; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   CHAIN           2..468
FT                   /note="RUS family member 1"
FT                   /id="PRO_0000282930"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   MOD_RES         49
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..262
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024255"
FT   VAR_SEQ         263..338
FT                   /note="CFFFLTALHIYANYRAVRALVMETLNEGRLRLVLKHYLQRGEVLDPTAANRM
FT                   EPLWTGFWPAPSLSLGVPLHRLVS -> MCLMGEGRMGRWGSWMTGYRKKGWIWCVWVM
FT                   AEGERKRGDLSEAWIISVHWVAVQWLVGHACLCCPPPPLHCPLPH (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_024256"
FT   VARIANT         43
FT                   /note="G -> E (in a breast cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_036485"
FT   VARIANT         185
FT                   /note="Y -> C (in dbSNP:rs17855405)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_031439"
FT   CONFLICT        449
FT                   /note="Q -> R (in Ref. 1; BAC03918)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        453
FT                   /note="D -> G (in Ref. 1; BAB14730)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   468 AA;  51018 MW;  A945866B56ED3B83 CRC64;
     MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV
     GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG
     VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI
     MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL
     AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
     QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ
     SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV
     KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL
 
 
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