RUSF1_MOUSE
ID RUSF1_MOUSE Reviewed; 466 AA.
AC Q91W34; Q3TCP4; Q3UEA8; Q3UFY1;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=RUS family member 1 {ECO:0000305};
GN Name=Rusf1 {ECO:0000312|MGI:MGI:2384572};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91W34-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91W34-2; Sequence=VSP_024257, VSP_024258;
CC -!- SIMILARITY: Belongs to the RUS1 family. {ECO:0000305}.
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DR EMBL; AK148236; BAE28428.1; -; mRNA.
DR EMBL; AK149645; BAE29003.1; -; mRNA.
DR EMBL; AK170611; BAE41911.1; -; mRNA.
DR EMBL; BC017158; AAH17158.1; -; mRNA.
DR CCDS; CCDS21895.1; -. [Q91W34-1]
DR RefSeq; NP_663565.2; NM_145590.2.
DR AlphaFoldDB; Q91W34; -.
DR STRING; 10090.ENSMUSP00000033044; -.
DR iPTMnet; Q91W34; -.
DR PhosphoSitePlus; Q91W34; -.
DR SwissPalm; Q91W34; -.
DR EPD; Q91W34; -.
DR MaxQB; Q91W34; -.
DR PaxDb; Q91W34; -.
DR PeptideAtlas; Q91W34; -.
DR PRIDE; Q91W34; -.
DR DNASU; 233913; -.
DR GeneID; 233913; -.
DR KEGG; mmu:233913; -.
DR UCSC; uc009jyv.2; mouse. [Q91W34-1]
DR CTD; 64755; -.
DR MGI; MGI:2384572; Rusf1.
DR eggNOG; KOG4249; Eukaryota.
DR InParanoid; Q91W34; -.
DR OrthoDB; 1357597at2759; -.
DR PhylomeDB; Q91W34; -.
DR TreeFam; TF326424; -.
DR BioGRID-ORCS; 233913; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q91W34; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91W34; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006968; RUS_fam.
DR PANTHER; PTHR12770; PTHR12770; 1.
DR Pfam; PF04884; UVB_sens_prot; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q96GQ5"
FT CHAIN 2..466
FT /note="RUS family member 1"
FT /id="PRO_0000282931"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q96GQ5"
FT VAR_SEQ 317..337
FT /note="TGFWPSLSLSLGVPLHHLVSS -> IGDPSLWFLVPGFPSLPSPSA (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024257"
FT VAR_SEQ 338..466
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024258"
FT CONFLICT 41
FT /note="G -> C (in Ref. 1; BAE28428)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="L -> F (in Ref. 1; BAE41911/BAE29003/BAE28428)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="Q -> R (in Ref. 1; BAE29003/BAE28428)"
FT /evidence="ECO:0000305"
FT CONFLICT 401
FT /note="E -> Q (in Ref. 1; BAE29003/BAE28428)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 466 AA; 50469 MW; B546CEDB8F8E4154 CRC64;
MADAASLRAP LCTEQFGSGA PRGCSAAADG SLQWDGARRW GWLSRAPIAK PGQHAGGGGG
PWAALTALSG LRSVLLPQGF PDSVSPDYLP YQLWDSVQAF ASSLSGSLAT QAVLQGLGVG
NAKASVSAAT STWLVKDSTG MLGRIILAWW KGSKLDCNAK QWRLFADILN DVAMFLEIMA
PMYPIFFTMT VSTSNLAKCI VGVAGGATRA ALTMHQARRN NMADVSAKDS SQETVVNLAG
LLVSLLMLPL VSDCPSLSLG CFVLLTALHI YANYRAVRAL VLETLNESRL QLVLEHFLQR
GEVLEPASAN QMEPLWTGFW PSLSLSLGVP LHHLVSSVSE LKQLVEGHHE PYLLCWNKSR
NQVQVALSQE AGPETVLRAA THGLILGALQ EDGPLPGELA ELRHQVQADP KKESWILVRE
THQVLDTLFP KFLKGLQAAG WKTEKHHLEV DEWRATWPLS PEKKVL