ID   BCSB_SALTI              Reviewed;         766 AA.
AC   Q8Z290;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Cyclic di-GMP-binding protein;
DE   AltName: Full=Cellulose synthase regulatory subunit;
DE   Flags: Precursor;
GN   Name=bcsB; OrderedLocusNames=STY4182, t3899;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Binds the cellulose synthase activator, bis-(3'-5') cyclic
CC       diguanylic acid (c-di-GMP). {ECO:0000250}.
CC   -!- PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis.
CC   -!- SUBUNIT: Tightly associated with the cellulose synthase catalytic
CC       subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AcsB/BcsB family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD08007.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71374.1; -; Genomic_DNA.
DR   RefSeq; NP_458302.1; NC_003198.1.
DR   RefSeq; WP_000823808.1; NZ_WSUR01000001.1.
DR   AlphaFoldDB; Q8Z290; -.
DR   SMR; Q8Z290; -.
DR   STRING; 220341.16504991; -.
DR   EnsemblBacteria; AAO71374; AAO71374; t3899.
DR   KEGG; stt:t3899; -.
DR   KEGG; sty:STY4182; -.
DR   PATRIC; fig|220341.7.peg.4271; -.
DR   eggNOG; COG1215; Bacteria.
DR   HOGENOM; CLU_003556_1_1_6; -.
DR   OMA; FQYMNPM; -.
DR   UniPathway; UPA00694; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR003920; Cell_synth_B.
DR   InterPro; IPR018513; Cell_synthase_bac.
DR   PANTHER; PTHR39083; PTHR39083; 1.
DR   Pfam; PF03170; BcsB; 1.
DR   PRINTS; PR01440; CELLSNTHASEB.
PE   3: Inferred from homology;
KW   c-di-GMP; Cell inner membrane; Cell membrane; Cellulose biosynthesis;
KW   Membrane; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..766
FT                   /note="Cyclic di-GMP-binding protein"
FT                   /id="PRO_0000000270"
FT   TOPO_DOM        36..729
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        730..750
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        751..766
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   766 AA;  84385 MW;  7707F50E9A077CCE CRC64;
     MKRKLSWMCA AVIGLSAFPA FMTAAAPAMP PLINAEPTEP AQSPVTEAPV VAQTAPSREV
     KLTFAQIAPP PGSMALRGVN PNGGIEFGMR SDEVASKAVL NLEYTPSPSL LPVQSQLKVY
     LNDELMGVLP VTKEQLGKKT LAQVPINPLF ITDFNRVRLE FVGHYRDVCE NPASSTLWLD
     IGRNSALDLT YNMLAVNNDL SHFPVPFFDP RDNRPVTLPI VFADMPDLAQ QQAASIVASW
     FGSRAGWRGQ RFPVLYNHLP DRNAIVFATN DRRPDFLRDH PAVNAPVIEM MNHPDNPYVK
     LLVVFGRDDK DLLQAAKGIA QGNILFRGSS VVVNDVKPLL ARKPYDAPNW VRTDRPVTFG
     ELKTYEEQLQ SSGLEPAPIN VSLNLPPDLY LLRSNGIDMD LNYRYTSPPT KDSSRLDISL
     NNQFLQAFSL NSTQETNRLL LRLPVLQGLL DGKTDVSIPA LKLGAMNQLR FDFRYMNPMP
     GGSVDNCITF QPVPNHVVIG DDSTIDFSKY YHFIAMPDLR AFANAGFPFS RMADLSDTLA
     VMPKTPTEAQ METLLNTVGA IGGQTGFPAI NLTITDDSAQ IADKDADLLI IGAIPGKLKD
     DKRIDLLVQA TQSWVKTPMR QTAFPSIMPD EADRAADAQS TVTASGPMAA VVGFQSPFND
     QRSVIALLAD SPRGYQLLND AVNDSGKRAA MFGSVAVIRE SGVHSLRVGD IYYVGHLPWF
     ERLWYALANH PVLLAVLAAL SVVLLAWVLW RLLRILSRRR LDPDHE