ID   BCSB_SALTY              Reviewed;         766 AA.
AC   Q93IN1;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Cyclic di-GMP-binding protein;
DE   AltName: Full=Cellulose synthase regulatory subunit;
DE   Flags: Precursor;
GN   Name=bcsB; OrderedLocusNames=STM3618;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028 / SGSG 2980 / CDC 6516-60 / NCTC 12023;
RX   PubMed=11260463; DOI=10.1046/j.1365-2958.2001.02337.x;
RA   Zogaj X., Nimtz M., Rohde M., Bokranz W., Roemling U.;
RT   "The multicellular morphotypes of Salmonella typhimurium and Escherichia
RT   coli produce cellulose as the second component of the extracellular
RT   matrix.";
RL   Mol. Microbiol. 39:1452-1463(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=11929533; DOI=10.1046/j.1365-2958.2002.02802.x;
RA   Solano C., Garcia B., Valle J., Berasain C., Ghigo J.-M., Gamazo C.,
RA   Lasa I.;
RT   "Genetic analysis of Salmonella enteritidis biofilm formation: critical
RT   role of cellulose.";
RL   Mol. Microbiol. 43:793-808(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Binds the cellulose synthase activator, bis-(3'-5') cyclic
CC       diguanylic acid (c-di-GMP). {ECO:0000250}.
CC   -!- PATHWAY: Glycan metabolism; bacterial cellulose biosynthesis.
CC   -!- SUBUNIT: Tightly associated with the cellulose synthase catalytic
CC       subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass
CC       type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AcsB/BcsB family. {ECO:0000305}.
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DR   EMBL; AJ315770; CAC44016.1; -; Genomic_DNA.
DR   EMBL; AJ315148; CAC86198.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22478.1; -; Genomic_DNA.
DR   RefSeq; NP_462519.1; NC_003197.2.
DR   RefSeq; WP_000823813.1; NC_003197.2.
DR   AlphaFoldDB; Q93IN1; -.
DR   SMR; Q93IN1; -.
DR   STRING; 99287.STM3618; -.
DR   PaxDb; Q93IN1; -.
DR   EnsemblBacteria; AAL22478; AAL22478; STM3618.
DR   GeneID; 1255141; -.
DR   KEGG; stm:STM3618; -.
DR   PATRIC; fig|99287.12.peg.3824; -.
DR   HOGENOM; CLU_003556_1_1_6; -.
DR   OMA; FQYMNPM; -.
DR   PhylomeDB; Q93IN1; -.
DR   BioCyc; SENT99287:STM3618-MON; -.
DR   UniPathway; UPA00694; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR003920; Cell_synth_B.
DR   InterPro; IPR018513; Cell_synthase_bac.
DR   PANTHER; PTHR39083; PTHR39083; 1.
DR   Pfam; PF03170; BcsB; 1.
DR   PRINTS; PR01440; CELLSNTHASEB.
PE   3: Inferred from homology;
KW   c-di-GMP; Cell inner membrane; Cell membrane; Cellulose biosynthesis;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..766
FT                   /note="Cyclic di-GMP-binding protein"
FT                   /id="PRO_0000000271"
FT   TOPO_DOM        29..729
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        730..750
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        751..766
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   766 AA;  84299 MW;  7E312F3D27CBE700 CRC64;
     MKRKLSWMCA AVIGLSAFPA FMTAAAPATP PLINAEPTEP APSPATEAPV VAQTAPSREV
     KLTFAQIAPP PGSMALRGVN PNGGIEFGMR SDEVASKAVL NLEYTPSPSL LPVQSQLKVY
     LNDELMGVLP VTKEQLGKKT LAQVPINPLF ITDFNRVRLE FVGHYRDVCE NPASSTLWLD
     IGRNSALDLT YNMLAVNNDL SHFPVPFFDP RDNRPVTLPI VFADMPDLAQ QQAASIVASW
     FGSRAGWRGQ RFPVLYNHLP DRNAIVFATN DRRPDFLRDH PAVNAPVIEM MSHPDNPYVK
     LLVVFGRDDK DLLQAAKGIA QGNILFRGSS VVVNDVKPLL ARKPYDAPNW VRTDRPVTFG
     ELKTYEEQLQ SSGLEPAPIN VSLNLPPDLY LLRSNGIDMD LNYRYTSPPT KDSSRLDISL
     NNQFLQAFSL NSTQETNRLL LRLPVLQGLL DGKTDVSIPA LKLGAMNQLR FDFRYMNPMP
     GGSVDNCITF QPVPNHVVIG DDSTIDFSKY YHFIAMPDLR AFANAGFPFS RMADLSDTLA
     VMPKTPTEAQ METLLNTVGA IGGQTGFPAI NLTITDDSAQ IADKDADLLI ISAIPGKLKD
     DKRIDLLVQA TQSWVKTPMR QTAFPSIMPD EADRAADAQS TVTASGPMAA VVGFQSPFND
     QRSVIALLAD SPRGYQLLND AVNDSGKRAA MFGSVAVIRE SGVHSLRVGD IYYVGHLPWF
     ERLWYALANH PVLLAVLAAL SVVLLAWVLW RLLRILSRRR LDPDHE