RUTC_ECOD1
ID RUTC_ECOD1 Reviewed; 128 AA.
AC C9QZ66; E6P339;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=3-aminoacrylate deaminase RutC {ECO:0000255|HAMAP-Rule:MF_00831};
DE Short=3-AA deaminase {ECO:0000255|HAMAP-Rule:MF_00831};
DE EC=3.5.-.- {ECO:0000255|HAMAP-Rule:MF_00831};
GN Name=rutC {ECO:0000255|HAMAP-Rule:MF_00831};
GN OrderedLocusNames=EcDH1_2632, ECDH1ME8569_0964;
OS Escherichia coli (strain ATCC 33849 / DSM 4235 / NCIMB 12045 / K12 / DH1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=536056;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33849 / DSM 4235 / NCIMB 12045 / K12 / DH1;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Keasling J.D.;
RT "Complete sequence of Escherichia coli DH1.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33849 / DSM 4235 / NCIMB 12045 / K12 / DH1;
RX PubMed=21611185; DOI=10.1371/journal.pone.0019534;
RA Suzuki S., Ono N., Furusawa C., Ying B.W., Yomo T.;
RT "Comparison of sequence reads obtained from three next-generation
RT sequencing platforms.";
RL PLoS ONE 6:E19534-E19534(2011).
CC -!- FUNCTION: Involved in pyrimidine catabolism. Catalyzes the deamination
CC of 3-aminoacrylate to malonic semialdehyde, a reaction that can also
CC occur spontaneously. RutC may facilitate the reaction and modulate the
CC metabolic fitness, rather than catalyzing essential functions.
CC {ECO:0000255|HAMAP-Rule:MF_00831}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(Z)-3-aminoacrylate + H(+) + H2O = 3-oxopropanoate + NH4(+);
CC Xref=Rhea:RHEA:34947, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:33190, ChEBI:CHEBI:59894;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00831};
CC -!- SUBUNIT: Homotrimer. {ECO:0000255|HAMAP-Rule:MF_00831}.
CC -!- SIMILARITY: Belongs to the RutC family. {ECO:0000255|HAMAP-
CC Rule:MF_00831}.
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DR EMBL; CP001637; ACX40266.1; -; Genomic_DNA.
DR EMBL; AP012030; BAJ42820.1; -; Genomic_DNA.
DR RefSeq; WP_001126780.1; NC_017638.1.
DR AlphaFoldDB; C9QZ66; -.
DR SMR; C9QZ66; -.
DR GeneID; 66670712; -.
DR KEGG; edh:EcDH1_2632; -.
DR KEGG; edj:ECDH1ME8569_0964; -.
DR PATRIC; fig|536056.19.peg.1021; -.
DR HOGENOM; CLU_100715_7_3_6; -.
DR OMA; MPKTIIT; -.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019740; P:nitrogen utilization; IEA:UniProtKB-UniRule.
DR GO; GO:0006212; P:uracil catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1330.40; -; 1.
DR HAMAP; MF_00831; RutC; 1.
DR InterPro; IPR019897; RidA_CS.
DR InterPro; IPR019898; RutC.
DR InterPro; IPR035959; RutC-like_sf.
DR InterPro; IPR006175; YjgF/YER057c/UK114.
DR PANTHER; PTHR11803; PTHR11803; 1.
DR Pfam; PF01042; Ribonuc_L-PSP; 1.
DR SUPFAM; SSF55298; SSF55298; 1.
DR TIGRFAMs; TIGR03610; RutC; 1.
DR PROSITE; PS01094; UPF0076; 1.
PE 3: Inferred from homology;
KW Hydrolase.
FT CHAIN 1..128
FT /note="3-aminoacrylate deaminase RutC"
FT /id="PRO_0000402722"
SQ SEQUENCE 128 AA; 13763 MW; 7D5FC2374597D907 CRC64;
MPKSVIIPAG SSAPLAPFVP GTLADGVVYV SGTLAFDQHN NVLFADDPKA QTRHVLETIR
KVIETAGGTM ADVTFNSIFI TDWKNYAAIN EIYAEFFPGD KPARFCIQCG LVKPDALVEI
ATIAHIAK
